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Licensed Unlicensed Requires Authentication Published by De Gruyter July 30, 2021

Electrospinning of chitosan-based nanofibers: from design to prospective applications

  • Alexandru Anisiei , Florin Oancea and Luminita Marin ORCID logo EMAIL logo


Chitosan is a biopolymer originating from renewable resources, with great properties which make it an attractive candidate for plenty of applications of contemporary interest. By manufacturing chitosan into nanofibers using the electrospinning method, its potential is amplified due to the enhancement of the active surface and the low preparation cost. Many attempts were made with the aim of preparing chitosan-based nanofibers with controlled morphology targeting their use for tissue engineering, wound healing, food packaging, drug delivery, air and water purification filters. This was a challenging task, which resulted in a high amount of data, sometimes with apparent contradictory results. In this light, the goal of the paper is to present the main routes reported in the literature for chitosan electrospinning, stressing the advantages and disadvantages of each of them. Special emphasis is placed on the influence of various electrospinning parameters on the morphological characteristics of the fibers and their suitability for distinct applications.

Corresponding author: Luminita Marin, “Petru Poni” Institute of Macromolecular Chemistry, Iasi 700487, Romania, E-mail:

Funding source: MEN–UEFISCDI

Award Identifier / Grant number: 10PCCDI/2018

Funding source: European Commission

Award Identifier / Grant number: SWORD- DLV-873123

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The financial support from the Romanian National Authority for Scientific Research MEN–UEFISCDI (PN-III-P1-1.2-PCCDI2017-0569, no. 10PCCDI/2018) and European Commission through the project H2020-MSCA-RISE-2019, SWORD-DLV-873123 is highly acknowledged.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.


Abbaspour, M., Sharif Makhmalzadeh, B., Rezaee, B., Shoja, S., and Ahangari, Z. (2015). Evaluation of the antimicrobial effect of chitosan/polyvinyl alcohol electrospun nanofibers containing mafenide acetate. Jundishapur J. Microbiol. 8: e24239, in Google Scholar PubMed PubMed Central

Abdelgawad, A.M., Hudson, S.M., and Rojas, O.J. (2014). Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydr. Polym. 100: 166–178, in Google Scholar PubMed

Ailincai, D., Marin, L., Morariu, S., Mares, M., Bostanaru, A.-C., Pinteala, M., Simionescu, B.C., and Barboiu, M. (2016). Dual crosslinked iminoboronate-chitosan hydrogels with strong antifungal activity against Candida planktonic yeasts and biofilms. Carbohydr. Polym. 152: 306–316, in Google Scholar PubMed

AL-Jbour, N.D., Beg, M.D., Gimbun, J., and Alam, A.K.M.M. (2019). An overview of chitosan nanofibers and their applications in the drug delivery process. Curr. Drug Deliv. 16: 272–294, in Google Scholar PubMed

Amiri, N., Rozbeh, Z., Afrough, T., Sajadi Tabassi, S.A., Moradi, A., and Movaffagh, J. (2018). Optimization of chitosan-gelatin nanofibers production: investigating the effect of solution properties and working parameters on fibers diameter. BioNanoScience 8: 778–789, in Google Scholar

An, J., Zhang, H., Zhang, J., Zhao, Y., and Yuan, X. (2009). Preparation and antibacterial activity of electrospun chitosan/poly(ethylene oxide) membranes containing silver nanoparticles. Colloid Polym. Sci. 287: 1425–1434, in Google Scholar

Asadian, M., Onyshchenko, I., Thukkaram, M., Esbah Tabaei, P.S., Van Guyse, J., Cools, P., Declercq, H., Hoogenboom, R., Morent, R., and De Geyter, N. (2018). Effects of a dielectric barrier discharge (DBD) treatment on chitosan/polyethylene oxide nanofibers and their cellular interactions. Carbohydr. Polym. 201: 402–415, in Google Scholar PubMed

Askari, M., Rezaei, B., Shoushtari, A.M., Noorpanah, P., Abdouss, M., and Ghani, M. (2014). Fabrication of high performance chitosan/polyvinyl alcohol nanofibrous mat with controlled morphology and optimised diameter. Can. J. Chem. Eng. 92: 1008–1015, in Google Scholar

Atakhanov, A. (2020). Nanofibers based on chitosan Bombyx mori. Am. J. Res. 11–12: 24–31.Search in Google Scholar

Augustine, R., Rehman, S.R.U., Ahmed, R., Zahid, A.A., Sharifi, M., Falahati, M., and Hasan, A. (2020). Electrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing. Int. J. Biol. Macromol. 156: 153–170, in Google Scholar PubMed

Bampidis, V., Azimonti, G., Bastos, M.D., Christensen, H., Dusemund, B., Kouba, M., Lopez-Alonso, M., Puente, S.L., Marcon, F., and Mayo, B., et al.. (2021). Safety and efficacy of a feed additive consisting of acetic acid for all animal species. EFSA Journal 19: e6615, doi:10.2903/j.efsa.2021.6615.10.2903/j.efsa.2021.6615Search in Google Scholar PubMed PubMed Central

Bazmandeh, A.Z., Mirzaei, E., Fadaie, M., Shirian, S., and Ghasemi, Y. (2020). Dual spinneret electrospun nanofibrous/gel structure of chitosan-gelatin/chitosan-hyaluronic acid as a wound dressing: in-vitro and in-vivo studies. Int. J. Biol. Macromol. 162: 359–373, in Google Scholar PubMed

Beauchamp, R.O., St Clair, M.B.G., Fennell, T.R., Clarke, D.O., Morgan, K.T., and Karl, F.W. (1992). A critical review of the toxicology of glutaraldehyde. Crit. Rev. Toxicol. 22: 143–174, in Google Scholar PubMed

Behbood, L., Karimi, S., Mirzaei, E., Mohammadi, G., Azami, M., and Arkan, E. (2018). Mucoadhesive chitosan electrospun nanofibers containing tetracycline and triamcinolone as a drug delivery system. Fibers Polym. 19: 1454–1462, in Google Scholar

Bejan, A., Ailincai, D., Simionescu, B.C., and Marin, L. (2018). Chitosan hydrogelation with a phenothiazine based aldehyde: a synthetic approach toward highly luminescent biomaterials. Polym. Chem. 9: 2359–2369, in Google Scholar

Bejan, A., Doroftei, F., Cheng, X., and Marin, L. (2020). Phenothiazine-chitosan based eco-adsorbents: a special design for mercury removal and fast naked eye detection. Int. J. Biol. Macromol. 162: 1839–1848, in Google Scholar PubMed

Bellich, B., D'Agostino, I., Semeraro, S., Gamini, A., and Cesàro, A. (2016). “The good, the bad and the ugly” of chitosans. Mar. Drugs 14: 99, in Google Scholar PubMed PubMed Central

Berger, J., Reist, M., Mayer, J.M., Felt, O., Peppas, N.A., and Gurny, R. (2004). Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur. J. Pharm. Biopharm. 57: 19–34, in Google Scholar PubMed

Bhardwaj, N. and Kundu, S.C. (2010). Electrospinning: a fascinating fiber fabrication technique. Biotechnol. Adv. 28: 325–347, in Google Scholar PubMed

Bhattarai, N., Edmondson, D., Veiseh, O., Matsen, F.A., and Zhang, M. (2005). Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials 26: 6176–6184, in Google Scholar PubMed

Biranje, S., Madiwale, P., and Adivarekar, R.V. (2017). Electrospinning of chitosan/PVA nanofibrous membrane at ultralow solvent concentration. J. Polym. Res. 24: 92, in Google Scholar

Bizarria, M.T.M., D'Ávila, M.A., and Mei, L.H.I. (2014). Non-woven nanofiber chitosan/peo membranes obtained by electrospinning. Braz. J. Chem. Eng. 31: 57–68, in Google Scholar

Bochek, A.M., Zabivalova, N.M., Brazhnikova, E.N., Anferova, M.S., and Lavrent'ev, V.K. (2019). Chitosan-polyamide composite nanofibers produced by needleless electrospinning. Fibre Chem. 50: 391–395, in Google Scholar

Bohlouli, N., Mirzaei, E., Ghanbari, H., Rezayat Sorkhabadi, S.M., and Faridi-Majid, R. (2018). Reinforcing mechanical strength of electrospun chitosan nanofibrous scaffold using cellulose nanofibers. J. Nano Res. 52: 71–79, in Google Scholar

Boschetto, F., Doan, H.N., Vo, P.P., Zanocco, M., Zhu, W., Sakai, W., Adachi, T., Ohgitani, E., and Tsutsumi, N. (2020). Antibacterial and osteoconductive effects of chitosan/polyethylene oxide (PEO)/bioactive glass nanofibers for orthopedic applications. Appl. Sci. 10: 2360, in Google Scholar

Cai, Z., Mo, X., Zhang, K., Fan, L., Yin, A., He, C., and Wang, H. (2010). Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications. Int. J. Mol. Sci. 11: 3529–3539, in Google Scholar PubMed PubMed Central

Cárdena-Pérez, Y.C., Vera-Graziano, R., Muñoz-Prieto, E.D.J., and Gómez-Pachón, E.Y. (2017). Preparation and characterization of scaffold nanofibers by electrospinning, based on chitosan and fibroin from Silkworm (Bombyx mori). Ing. Compet. 19: 139–151, in Google Scholar

Casasola, R., Thomas, N.L., Trybala, A., and Georgiadou, S. (2014). Electrospun poly lactic acid (PLA) fibres: effect of different solvent systems on fibre morphology and diameter. Polymer 55: 4728–4737, in Google Scholar

Charernsriwilaiwat, N., Rojanarata, T., Ngawhirunpat, T., and Opanasopit, P. (2014). Electrospun chitosan/polyvinyl alcohol nanofibre mats for wound healing. Int. Wound J. 11: 215–222, in Google Scholar

Chen, J.-P., Chen, S.-H., and Lai, G.-J. (2012). Preparation and characterization of biomimetic silk fibroin/chitosan composite nanofibers by electrospinning for osteoblasts culture. Nanoscale Res. Lett. 7: 170, in Google Scholar

Chen, L., Zhu, C., Fan, D., Liu, B., Ma, X., Duan, Z., and Zhou, Y. (2011). A human-like collagen/chitosan electrospun nanofibrous scaffold from aqueous solution: electrospun mechanism and biocompatibility. J. Biomed. Mater. Res. A 99A: 395–409, in Google Scholar PubMed

Chen, Y., Shafiq, M., Liu, M., Morsi, Y., and Mo, X. (2020). Advanced fabrication for electrospun three-dimensional nanofiber aerogels and scaffolds. Bioact. Mater. 5: 963–979, in Google Scholar PubMed PubMed Central

Chen, Z., Mo, X., and Qing, F. (2007). Electrospinning of collagen–chitosan complex. Mater. Lett. 61: 3490–3494, in Google Scholar

Chen, Z.-G., Wei, B., Mo, X.-M., and Cui, F.-Z. (2009). Diameter control of electrospun chitosan-collagen fibers. J. Polym. Sci. B Polym. Phys. 47: 1949–1955, in Google Scholar

Cheng, F., Gao, J., Wang, L., and Hu, X. (2015). Composite chitosan/poly(ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs. J. Appl. Polym. Sci. 132: 42060, in Google Scholar

Choi, Y., Park, M.H., and Lee, K. (2020). Injectable thermoresponsive hydrogel/nanofiber hybrid scaffolds inducing human adipose-derived stem cell chemotaxis. J. Ind. Eng. Chem. 82: 89–97, in Google Scholar

Cooper, A., Bhattarai, N., and Zhang, M. (2011). Fabrication and cellular compatibility of aligned chitosan–PCL fibers for nerve tissue regeneration. Carbohydr. Polym. 85: 149–156, in Google Scholar

Cremar, L., Gutierrez, J., Martinez, J., Materon, L., Gilkerson, R., Xu, F., and Lozano, K. (2018). Development of antimicrobial chitosan based nanofiber dressings for wound healing applications. Nanomed. J. 5: 6–14.Search in Google Scholar

Deng, A., Yang, Y., Du, S., and Yang, S. (2018a). Electrospinning of in situ crosslinked recombinant human collagen peptide/chitosan nanofibers for wound healing. Biomater. Sci. 6: 2197–2208, in Google Scholar PubMed

Deng, L., Taxipalati, M., Zhang, A., Que, F., Wei, H., Feng, F., and Zhang, H. (2018b). Electrospun chitosan/poly(ethylene oxide)/lauric arginate nanofibrous film with enhanced antimicrobial activity. J. Agric. Food Chem. 66: 6219–6226, in Google Scholar PubMed

Denis, P., Wrzecionek, M., Gadomska-Gajadhur, A., and Sajkiewicz, P. (2019). Poly(glycerol sebacate)–poly(l-lactide) nonwovens. Towards attractive electrospun material for tissue engineering. Polymers 11: 2113, in Google Scholar PubMed PubMed Central

Desai, K., Kit, K., Li, J., and Zivanovic, S. (2008). Morphological and surface properties of electrospun chitosan nanofibers. Biomacromolecules 9: 1000–1006, in Google Scholar PubMed

Desai, K., Kit, K., Li, J., Michael Davidson, P., Zivanovic, S., and Meyer, H. (2009). Nanofibrous chitosan non-wovens for filtration applications. Polymer 50: 3661–3669, in Google Scholar

Dhandayuthapani, B., Krishnan, U.M., and Sethuraman, S. (2010). Fabrication and characterization of chitosan-gelatin blend nanofibers for skin tissue engineering. J. Biomed. Mater. Res. B Appl. Biomater. 94B: 264–272, in Google Scholar PubMed

Dhawane, M., Deshpande, A., Jain, R., and Dandekar, P. (2019). Colorimetric point-of-care detection of cholesterol using chitosan nanofibers. Sensor. Actuator. B Chem. 281: 72–79, in Google Scholar

Dhurai, B., Saraswathy, N., Maheswaran, R., Sethupathi, P., Vanitha, P., Vigneshwaran, S., and Rameshbabu, V. (2013). Electrospinning of curcumin loaded chitosan/poly (lactic acid) nanofilm and evaluation of its medicinal characteristics. Front. Mater. Sci. 7: 350–361, in Google Scholar

Dilamian, M., Montazer, M., and Masoumi, J. (2013). Antimicrobial electrospun membranes of chitosan/poly(ethylene oxide) incorporating poly(hexamethylene biguanide) hydrochloride. Carbohydr. Polym. 94: 364–371, in Google Scholar PubMed

Doğan, G., Özyıldız, F., Başal, G., and Uzel, A. (2013). Fabrication of electrospun chitosan and chitosan/poly(ethylene oxide) nanofiber webs and assessment of their antimicrobial activity. Int. Polym. Process. 28: 143–150.10.3139/217.2604Search in Google Scholar

Du, J. and Hsieh, Y.-L. (2009). Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives. Cellulose 16: 247–260, in Google Scholar

Du, Y., Wei, S., Tang, M., Ye, M., Tao, H., Qi, C., and Shao, L. (2020). Palladium nanoparticles stabilized by chitosan/PAAS nanofibers: a highly stable catalyst for Heck reaction. Appl. Organomet. Chem. 34: e5619, in Google Scholar

Duan, B., Dong, C., Yuan, X., and Yao, K. (2004). Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide). J. Biomater. Sci. Polym. Ed. 15: 797–811, in Google Scholar PubMed

Duceac, I.A., Verestiuc, L., Dimitriu, C.D., Maier, V., and Coseri, S. (2020). Design and preparation of new multifunctional hydrogels based on chitosan/acrylic polymers for drug delivery and wound dressing applications. Polymers 12: 1473, in Google Scholar PubMed PubMed Central

Elsabee, M.Z., Naguib, H.F., and Morsi, R.E. (2012). Chitosan based nanofibers, review. Mater. Sci. Eng. C 32: 1711–1726, in Google Scholar PubMed

Emamgholi, A., Rahimi, M., Kaka, G., Sadraie, S.H., and Najafi, S. (2015). Presentation of a novel model of chitosan- polyethylene oxide-nanohydroxyapatite nanofibers together with bone marrow stromal cells to repair and improve minor bone defects. Iran. J. Basic Med. Sci. 18: 887–893.Search in Google Scholar

Erdem, R. and Akalın, M. (2015). Characterization and evaluation of antimicrobial properties of electrospun chitosan/polyethylene oxide based nanofibrous scaffolds (with/without nanosilver). J. Ind. Textil. 44: 553–571, in Google Scholar

de Farias, B.S., Vidal, É.M., Ribeiro, N.T., da Silveira, N., da Silva Vaz, B., Kuntzler, S.G., de Morais, M.G., Cadaval, T.R.S., and de Almeida Pinto, L.A. (2018). Electrospun chitosan/poly(ethylene oxide) nanofibers applied for the removal of glycerol impurities from biodiesel production by biosorption. J. Mol. Liq. 268: 365–370, in Google Scholar

Fazli, Y. and Shariatinia, Z. (2017). Controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous mats. Mater. Sci. Eng. C 71: 641–652, in Google Scholar PubMed

Galed, G., Mirabelles, B., Panosi, I., Santiago, A., and Heras, A. (2005). Deacetylation and depolymerization reactions of chitin/chitosan: influence of the source of chitin. Carbohydr. Polym. 62: 316–320, in Google Scholar

Ge, L., Zhao, Y., Mo, T., Li, J., and Li, P. (2012). Immobilization of glucose oxidase in electrospun nanofibrous membranes for food preservation. Food Contr. 26: 188–193, in Google Scholar

Geng, X., Kwon, O., and Jang, J. (2005). Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials 26: 5427–5432, in Google Scholar PubMed

Ghani, M., Gharehaghaji, A.A., Arami, M., Takhtkuse, N., and Rezaei, B. (2014). Fabrication of electrospun polyamide-6/chitosan nanofibrous membrane toward anionic dyes removal. J. Nanotechnol. 2014: 1–12, in Google Scholar

Ghiorghita, C.-A., Borchert, K.B.L., Vasiliu, A.-L., Zaharia, M.-M., Schwarz, D., and Mihai, M. (2020). Porous thiourea-grafted-chitosan hydrogels: synthesis and sorption of toxic metal ions from contaminated waters. Colloid. Surface. A Physicochem. Eng. Aspect. 607: 125504, in Google Scholar

Ghorbani, F.M., Kaffashi, B., Shokrollahi, P., Seyedjafari, E., and Ardeshirylajimi, A. (2015). PCL/chitosan/Zn-doped nHA electrospun nanocomposite scaffold promotes adipose derived stem cells adhesion and proliferation. Carbohydr. Polym. 118: 133–142, in Google Scholar PubMed

Gómez-Guillén, M.C., Giménez, B., López-Caballero, M.E., and Montero, M.P. (2011). Functional and bioactive properties of collagen and gelatin from alternative sources: a review. Food Hydrocolloids 25: 1813–1827, in Google Scholar

Greiner, A. and Wendorff, J.H. (2007). Electrospinning: a fascinating method for the preparation of ultrathin fibers. Angew. Chem. Int. Ed. 46: 5670–5703, in Google Scholar PubMed

Grkovic, M., Stojanovic, D.B., Pavlovic, V.B., Rajilic-Stojanovic, M., Bjelovic, M., and Uskokovic, P.S. (2017). Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. Compos. B Eng. 121: 58–67, in Google Scholar

Gu, B.K., Park, S.J., Kim, M.S., Kang, C.M., Kim, J.-I., and Kim, C.-H. (2013). Fabrication of sonicated chitosan nanofiber mat with enlarged porosity for use as hemostatic materials. Carbohydr. Polym. 97: 65–73, in Google Scholar PubMed

Guarino, V., Gentile, G., Sorrentino, L., and Ambrosio, L. (2017). Polycaprolactone: synthesis, properties, and applications. In: Encyclopedia of polymer science and technology. John Wiley & Sons, Inc., Hoboken, NJ, USA, pp. 1–36.10.1002/0471440264.pst658Search in Google Scholar

Habiba, U., Afifi, A.M., Salleh, A., and Ang, B.C. (2017a). Chitosan/(polyvinyl alcohol)/zeolite electrospun composite nanofibrous membrane for adsorption of Cr6+, Fe3+ and Ni2+. J. Hazard Mater. 322: 182–194, in Google Scholar PubMed

Habiba, U., Siddique, T.A., Talebian, S., Lee, J.J.L., Salleh, A., Ang, B.C., and Afifi, A.M. (2017b). Effect of deacetylation on property of electrospun chitosan/PVA nanofibrous membrane and removal of methyl orange, Fe(III) and Cr(VI) ions. Carbohydr. Polym. 177: 32–39, in Google Scholar PubMed

Hadipour-Goudarzi, E., Montazer, M., Latifi, M., and Aghaji, A.A.G. (2014). Electrospinning of chitosan/sericin/PVA nanofibers incorporated with in situ synthesis of nano silver. Carbohydr. Polym. 113: 231–239, in Google Scholar PubMed

Haghju, S., Bari, M.R., and Khaled-Abad, M.A. (2018). Affecting parameters on fabrication of β-D-galactosidase immobilized chitosan/poly (vinyl alcohol) electrospun nanofibers. Carbohydr. Polym. 200: 137–143, in Google Scholar PubMed

Haider, S., Al-Zeghayer, Y., Ahmed Ali, F.A., Haider, A., Mahmood, A., Al-Masry, W.A., Imran, M., and Aijaz, M.O. (2013). Highly aligned narrow diameter chitosan electrospun nanofibers. J. Polym. Res. 20: 105, in Google Scholar

Haider, S. and Park, S.-Y. (2009). Preparation of the electrospun chitosan nanofibers and their applications to the adsorption of Cu(II) and Pb(II) ions from an aqueous solution. J. Membr. Sci. 328: 90–96, in Google Scholar

Hang, A.T., Tae, B., and Park, J.S. (2010). Non-woven mats of poly(vinyl alcohol)/chitosan blends containing silver nanoparticles: fabrication and characterization. Carbohydr. Polym. 82: 472–479, in Google Scholar

Hardiansyah, A., Tanadi, H., Yang, M.-C., and Liu, T.-Y. (2015). Electrospinning and antibacterial activity of chitosan-blended poly(lactic acid) nanofibers. J. Polym. Res. 22: 59, in Google Scholar

Horzum, N., Boyacı, E., Eroğlu, A.E., Shahwan, T., and Demir, M.M. (2010). Sorption efficiency of chitosan nanofibers toward metal ions at low concentrations. Biomacromolecules 11: 3301–3308, in Google Scholar PubMed

Huang, X.-J., Ge, D., and Xu, Z.-K. (2007). Preparation and characterization of stable chitosan nanofibrous membrane for lipase immobilization. Eur. Polym. J. 43: 3710–3718, in Google Scholar

Iftime, M.M. and Marin, L. (2018). Chiral betulin-imino-chitosan hydrogels by dynamic covalent sonochemistry. Ultrason. Sonochem. 45: 238–247, in Google Scholar PubMed

Iftime, M.-M., Morariu, S., and Marin, L. (2017). Salicyl-imine-chitosan hydrogels: supramolecular architecturing as a crosslinking method toward multifunctional hydrogels. Carbohydr. Polym. 165: 39–50, in Google Scholar PubMed

Iftime, M.M., Ailiesei, G.L., Ungureanu, E., and Marin, L. (2019). Designing chitosan based eco-friendly multifunctional soil conditioner systems with urea controlled release and water retention. Carbohydr. Polym. 223: 115040, in Google Scholar PubMed

Ignatova, M., Manolova, N., Markova, N., and Rashkov, I. (2009). Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications. Macromol. Biosci. 9: 102–111, in Google Scholar PubMed

Jabur, A.R., Abbas, L.K., and Moosa, S.A. (2016). Fabrication of electrospun chitosan/nylon 6 nanofibrous membrane toward metal ions removal and antibacterial effect. Adv. Mater. Sci. Eng. 2016: 1–10, in Google Scholar

Jia, Y.-T., Gong, J., Gu, X.-H., Kim, H.-Y., Dong, J., and Shen, X.-Y. (2007). Fabrication and characterization of poly (vinyl alcohol)/chitosan blend nanofibers produced by electrospinning method. Carbohydr. Polym. 67: 403–409, in Google Scholar

Jin, Y., Yang, D., Zhou, Y., Ma, G., and Nie, J. (2008). Photocrosslinked electrospun chitosan-based biocompatible nanofibers. J. Appl. Polym. Sci. 109: 3337–3343, in Google Scholar

Kalantari, K., Afifi, A.M., Jahangirian, H., and Webster, T.J. (2019). Biomedical applications of chitosan electrospun nanofibers as a green polymer – review. Carbohydr. Polym. 207: 588–600, in Google Scholar PubMed

Kang, W.M., Cheng, B.W., Li, Q.X., and Zuo, F.F. (2010). Novel antibacterial nanofibers of chitosan and polyurethane prepared by electrospinning. Adv. Mater. Res. 150–151: 1452–1456, in Google Scholar

Kianfar, P., Vitale, A., Dalle Vacche, S., and Bongiovanni, R. (2019). Photo-crosslinking of chitosan/poly(ethylene oxide) electrospun nanofibers. Carbohydr. Polym. 217: 144–151, in Google Scholar PubMed

Kievit, F.M., Cooper, A., Jana, S., Leung, M.C., Wang, K., Edmondson, D., Wood, D., Lee, J.S.H., Ellenbogen, R.G., and Zhang, M. (2013). Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells. Adv. Healthc. Mater. 2: 1651–1659, in Google Scholar PubMed PubMed Central

Kim, S.S. and Lee, J. (2014). Antibacterial activity of polyacrylonitrile–chitosan electrospun nanofibers. Carbohydr. Polym. 102: 231–237, in Google Scholar PubMed

Kiristi, M., Oksuz, A.U., Oksuz, L., and Ulusoy, S. (2013). Electrospun chitosan/PEDOT nanofibers. Mater. Sci. Eng. C 33: 3845–3850, in Google Scholar PubMed

Koosha, M. and Mirzadeh, H. (2015). Electrospinning, mechanical properties, and cell behavior study of chitosan/PVA nanofibers. J. Biomed. Mater. Res. A 103: 3081–3093, in Google Scholar PubMed

Koosha, M., Mirzadeh, H., Shokrgozar, M.A., and Farokhi, M. (2015). Nanoclay-reinforced electrospun chitosan/PVA nanocomposite nanofibers for biomedical applications. RSC Adv. 5: 10479–10487, in Google Scholar

Koosha, M., Raoufi, M., and Moravvej, H. (2019). One-pot reactive electrospinning of chitosan/PVA hydrogel nanofibers reinforced by halloysite nanotubes with enhanced fibroblast cell attachment for skin tissue regeneration. Colloids Surf. B Biointerfaces 179: 270–279, in Google Scholar PubMed

Kriegel, C., Arrechi, A., Kit, K., McClements, D.J., and Weiss, J. (2008). Fabrication, functionalization, and application of electrospun biopolymer nanofibers. Crit. Rev. Food Sci. Nutr. 48: 775–797, in Google Scholar PubMed

Kriegel, C., Kit, K.M., McClements, D.J., and Weiss, J. (2009). Influence of surfactant type and concentration on electrospinning of chitosan–poly(ethylene oxide) blend nanofibers. Food Biophys. 4: 213–228, in Google Scholar

Kritchenkov, A.S., Andranovitš, S., and Skorik, Y.A. (2017). Chitosan and its derivatives: vectors in gene therapy. Russ. Chem. Rev. 86: 231–239, in Google Scholar

Lee, D.-M., Kao, C.-W., Huang, T.-W., You, J.-H., and Liu, S.-J. (2016). Electrospinning of sheath-core structured chitosan/polylactide nanofibers for the removal of metal ions. Int. Polym. Process. 31: 533–540, in Google Scholar

Lee, S.J., Heo, D.N., Moon, J.-H., Park, H.N., Ko, W.-K., Bae, M.S., Lee, J.B., Park, S.W., Kim, E.C., Lee, C.H., et al. (2014). Chitosan/polyurethane blended fiber sheets containing silver sulfadiazine for use as an antimicrobial wound dressing. J. Nanosci. Nanotechnol. 14: 7488–7494, in Google Scholar PubMed

Lemma, S.M., Bossard, F., and Rinaudo, M. (2016). Preparation of pure and stable chitosan nanofibers by electrospinning in the presence of poly (ethylene oxide). Int. J. Mol. Sci. 17: 1790, in Google Scholar PubMed PubMed Central

Li, C., Lou, T., Yan, X., Long, Y., Cui, G., and Wang, X. (2018). Fabrication of pure chitosan nanofibrous membranes as effective absorbent for dye removal. Int. J. Biol. Macromol. 106: 768–774, in Google Scholar PubMed

Li, L. and Hsieh, Y.-L. (2006). Chitosan bicomponent nanofibers and nanoporous fibers. Carbohydr. Res. 341: 374–381, in Google Scholar PubMed

Li, L., Li, Y., Cao, L., and Yang, C. (2015). Enhanced chromium (VI) adsorption using nanosized chitosan fibers tailored by electrospinning. Carbohydr. Polym. 125: 206–213, in Google Scholar PubMed

Li, W., Luo, T., Shi, Y., Yang, Y., Huang, X., Xing, K., Liu, L., and Wang, M. (2014). Preparation, characterization, and property of chitosan/polyethylene oxide electrospun nanofibrous membrane for controlled drug release. Integrated Ferroelectrics Int. J. 151: 164–178, in Google Scholar

Li, Y., Chen, F., Nie, J., and Yang, D. (2012). Electrospun poly(lactic acid)/chitosan core–shell structure nanofibers from homogeneous solution. Carbohydr. Polym. 90: 1445–1451, in Google Scholar PubMed

Liu, F., Liu, Y., Sun, Z., Wang, D., Wu, H., Du, L., and Wang, D. (2020). Preparation and antibacterial properties of ε-polylysine-containing gelatin/chitosan nanofiber films. Int. J. Biol. Macromol. 164: 3376–3387, in Google Scholar PubMed

Liu, W., Zhan, J., Su, Y., Wu, T., Wu, C., Ramakrishna, S., Mo, X., Al-Deyab, S.S., and El-Newehy, M. (2014a). Effects of plasma treatment to nanofibers on initial cell adhesion and cell morphology. Colloids Surf. B Biointerfaces 113: 101–106, in Google Scholar PubMed

Liu, Y., Park, M., Shin, H.K., Pant, B., Park, S.-J., and Kim, H.-Y. (2014b). Preparation and characterization of chitosan-based nanofibers by ecofriendly electrospinning. Mater. Lett. 132: 23–26, in Google Scholar

Liverani, L., Lacina, J., Roether, J.A., Boccardi, E., Killian, M.S., Schmuki, P., Schubert, D.W., and Boccaccini, A.R. (2018). Incorporation of bioactive glass nanoparticles in electrospun PCL/chitosan fibers by using benign solvents. Bioact. Mater. 3: 55–63, in Google Scholar PubMed PubMed Central

Lopes-da-Silva, J.A., Veleirinho, B., and Delgadillo, I. (2009). Preparation and characterization of electrospun mats made of PET/chitosan hybrid nanofibers. J. Nanosci. Nanotechnol. 9: 3798–3804, in Google Scholar PubMed

Ma, G., Liu, Y., Peng, C., Fang, D., He, B., and Nie, J. (2011). Paclitaxel loaded electrospun porous nanofibers as mat potential application for chemotherapy against prostate cancer. Carbohydr. Polym. 86: 505–512, in Google Scholar

Ma, G., Liu, Y., Fang, D., Chen, J., Peng, C., Fei, X., and Nie, J. (2012). Hyaluronic acid/chitosan polyelectrolyte complexes nanofibers prepared by electrospinning. Mater. Lett. 74: 78–80, in Google Scholar

Mahoney, C., Conklin, D., Waterman, J., Sankar, J., and Bhattarai, N. (2016). Electrospun nanofibers of poly(ε-caprolactone)/depolymerized chitosan for respiratory tissue engineering applications. J. Biomater. Sci. Polym. Ed. 27: 611–625, in Google Scholar PubMed

Marin, L., Ailincai, D., Mares, M., Paslaru, E., Cristea, M., Nica, V., and Simionescu, B.C. (2015). Imino-chitosan biopolymeric films. Obtaining, self-assembling, surface and antimicrobial properties. Carbohydr. Polym. 117: 762–770, in Google Scholar PubMed

Marin, L., Dragoi, B., Olaru, N., Perju, E., Coroaba, A., Doroftei, F., Scavia, G., Destri, S., Zappia, S., and Porzio, W. (2019). Nanoporous furfuryl-imine-chitosan fibers as a new pathway towards eco-materials for CO2 adsorption. Eur. Polym. J. 120: 109214, in Google Scholar

Matsuda, A., Kagata, G., Kino, R., and Tanaka, J. (2007). Preparation of chitosan nanofiber tube by electrospinning. J. Nanosci. Nanotechnol. 7: 852–855, in Google Scholar PubMed

Min, B.-M., Lee, S.W., Lim, J.N., You, Y., Lee, T.S., Kang, P.H., and Park, W.H. (2004). Chitin and chitosan nanofibers: electrospinning of chitin and deacetylation of chitin nanofibers. Polymer 45: 7137–7142, in Google Scholar

Min, L.-L., Yuan, Z.-H., Zhong, L.-B., Liu, Q., Wu, R.-X., and Zheng, Y.-M. (2015). Preparation of chitosan based electrospun nanofiber membrane and its adsorptive removal of arsenate from aqueous solution. Chem. Eng. J. 267: 132–141, in Google Scholar

Min, L.-L., Zhong, L.-B., Zheng, Y.-M., Liu, Q., Yuan, Z.-H., and Yang, L.-M. (2016). Functionalized chitosan electrospun nanofiber for effective removal of trace arsenate from water. Sci. Rep. 6: 32480, in Google Scholar PubMed PubMed Central

Mohammed, M., Syeda, J., Wasan, K., and Wasan, E. (2017). An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics 9: 53, in Google Scholar PubMed PubMed Central

Mohraz, M.H., Golbabaei, F., Yu, I.J., Mansournia, M.A., Zadeh, A.S., and Dehghan, S.F. (2019). Preparation and optimization of multifunctional electrospun polyurethane/chitosan nanofibers for air pollution control applications. Int. J. Environ. Sci. Technol. 16: 681–694, in Google Scholar

Montembault, A., Viton, C., and Domard, A. (2005). Rheometric study of the gelation of chitosan in aqueous solution without cross-linking agent. Biomacromolecules 6: 653–662, in Google Scholar PubMed

Moutsatsou, P., Coopman, K., and Georgiadou, S. (2017). Biocompatibility assessment of conducting PANI/chitosan nanofibers for wound healing applications. Polymers 9: 687, in Google Scholar PubMed PubMed Central

Moutsatsou, P., Coopman, K., and Georgiadou, S. (2019). Chitosan & conductive PANI/chitosan composite nanofibers – evaluation of antibacterial properties. Curr. Nanomater. 4: 6–20, in Google Scholar

Munteanu, B., Dumitriu, R., Profire, L., Sacarescu, L., Hitruc, G., Stoleru, E., Dobromir, M., Matricala, A., and Vasile, C. (2016). Hybrid nanostructures containing sulfadiazine modified chitosan as antimicrobial drug carriers. Nanomaterials 6: 207, in Google Scholar PubMed PubMed Central

Munteanu, B., Sacarescu, L., Vasiliu, A.-L., Hitruc, G., Pricope, G., Sivertsvik, M., Rosnes, J., and Vasile, C. (2018). Antioxidant/antibacterial electrospun nanocoatings applied onto PLA films. Materials 11: 1973, in Google Scholar PubMed PubMed Central

Nair, B. (1998). Final report on the safety assessment of polyvinyl alcohol. Int. J. Toxicol. 17(Suppl. 5): 67–92.10.1177/109158189801700505Search in Google Scholar

Naseri, N., Mathew, A.P., Girandon, L., Fröhlich, M., and Oksman, K. (2015). Porous electrospun nanocomposite mats based on chitosan–cellulose nanocrystals for wound dressing: effect of surface characteristics of nanocrystals. Cellulose 22: 521–534, in Google Scholar

Nawalakhe, R., Shi, Q., Vitchuli, N., Bourham, M.A., Zhang, X., and McCord, M.G. (2015). Plasma-assisted preparation of high-performance chitosan nanofibers/gauze composite bandages. Int. J. Polym. Mater. Polym. Biomater. 64: 709–717, in Google Scholar

Nguyen, T.T.T., Chung, O.H., and Park, J.S. (2011). Coaxial electrospun poly(lactic acid)/chitosan (core/shell) composite nanofibers and their antibacterial activity. Carbohydr. Polym. 86: 1799–1806, in Google Scholar

Nien, Y.-H., Wang, J.-Y., and Tsai, Y.-S. (2013). The preparation and characterization of highly aligned poly(ε-caprolactone)/poly ethylene oxide/chitosan ultrafine fiber for the application to tissue scaffold. J. Nanosci. Nanotechnol. 13: 4703–4707, in Google Scholar PubMed

Nikbakht, M., Salehi, M., Rezayat, S.M., and Majidi, R.F. (2020). Various parameters in the preparation of chitosan/polyethylene oxide electrospun nanofibers containing Aloe vera extract for medical applications. Nanomed. J. 7: 21–28.Search in Google Scholar

Nirmala, R., Il, B.W., Navamathavan, R., El-Newehy, M.H., and Kim, H.Y. (2011a). Preparation and characterizations of anisotropic chitosan nanofibers via electrospinning. Macromol. Res. 19: 345–350, in Google Scholar

Nirmala, R., Navamathavan, R., Kang, H.-S., El-Newehy, M.H., and Kim, H.Y. (2011b). Preparation of polyamide-6/chitosan composite nanofibers by a single solvent system via electrospinning for biomedical applications. Colloids Surf. B Biointerfaces 83: 173–178, in Google Scholar PubMed

Noriega, S.E., Hasanova, G.I., Schneider, M.J., Larsen, G.F., and Subramanian, A. (2012). Effect of fiber diameter on the spreading, proliferation and differentiation of chondrocytes on electrospun chitosan matrices. Cells Tissues Organs 195: 207–221, in Google Scholar PubMed PubMed Central

Ohkawa, K., Cha, D., Kim, H., Nishida, A., and Yamamoto, H. (2004). Electrospinning of chitosan. Macromol. Rapid Commun. 25: 1600–1605, in Google Scholar

Ojha, S.S., Stevens, D.R., Hoffman, T.J., Stano, K., Klossner, R., Scott, M.C., Krause, W., Clarke, L.I., and Gorga, R.E. (2008). Fabrication and characterization of electrospun chitosan nanofibers formed via templating with polyethylene oxide. Biomacromolecules 9: 2523–2529, in Google Scholar PubMed

Olaru, A.-M., Marin, L., Morariu, S., Pricope, G., Pinteala, M., and Tartau-Mititelu, L. (2018). Biocompatible chitosan based hydrogels for potential application in local tumour therapy. Carbohydr. Polym. 179: 59–70, in Google Scholar PubMed

Pakravan, M., Heuzey, M.-C., and Ajji, A. (2011). A fundamental study of chitosan/PEO electrospinning. Polymer 52: 4813–4824, in Google Scholar

Pakravan, M., Heuzey, M.-C., and Ajji, A. (2012). Core–shell structured PEO-chitosan nanofibers by coaxial electrospinning. Biomacromolecules 13: 412–421, in Google Scholar PubMed

Pangon, A., Saesoo, S., Saengkrit, N., Ruktanonchai, U., and Intasanta, V. (2016). Multicarboxylic acids as environment-friendly solvents and in situ crosslinkers for chitosan/PVA nanofibers with tunable physicochemical properties and biocompatibility. Carbohydr. Polym. 138: 156–165, in Google Scholar PubMed

Park, J.H., Lee, H.W., Chae, D.K., Oh, W., Yun, J.D., Deng, Y., and Yeum, J.H. (2009). Electrospinning and characterization of poly(vinyl alcohol)/chitosan oligosaccharide/clay nanocomposite nanofibers in aqueous solutions. Colloid Polym. Sci. 287: 943–950, in Google Scholar

Park, W.H., Jeong, L., Yoo, D.I., and Hudson, S. (2004). Effect of chitosan on morphology and conformation of electrospun silk fibroin nanofibers. Polymer 45: 7151–7157, in Google Scholar

Pebdeni, A.B., Sadri, M., and Pebdeni, S.B. (2016). Synthesis of chitosan/PEO/silica nanofiber coating for controlled release of cefepime from implants. RSC Adv. 6: 24418–24429, in Google Scholar

Petrova, V.A., Chernyakov, D.D., Poshina, D.N., Gofman, I.V., Romanov, D.P., Mishanin, A.I., Golovkin, A.S., and Skorik, Y.A. (2019). Electrospun bilayer chitosan/hyaluronan material and its compatibility with mesenchymal stem cells. Materials 12: 2016, in Google Scholar PubMed PubMed Central

Pezeshki-Modaress, M., Zandi, M., and Mirzadeh, H. (2015). Fabrication of gelatin/chitosan nanofibrous scaffold: process optimization and empirical modeling. Polym. Int. 64: 571–580, in Google Scholar

Phan, D.-N., Lee, H., Huang, B., Mukai, Y., and Kim, I.-S. (2019). Fabrication of electrospun chitosan/cellulose nanofibers having adsorption property with enhanced mechanical property. Cellulose 26: 1781–1793, in Google Scholar

Poshina, D.N., Khadyko, I.A., Sukhova, A.A., Serov, I.V., Zabivalova, N.M., and Skorik, Y.A. (2019). Needleless electrospinning of a chitosan lactate aqueous solution: influence of solution composition and spinning parameters. Technologies 8: 2, in Google Scholar

Pouranvari, S., Ebrahimi, F., Javadi, G., and Maddah, B. (2016). Chemical cross-linking of chitosan/polyvinyl alcohol electrospun nanofibers. Mater. Tehnol. 50: 663–666, in Google Scholar

Prabhakaran, M.P., Venugopal, J.R., Chyan, T.T., Hai, L.B., Chan, C.K., Lim, A.Y., and Ramakrishna, S. (2008). Electrospun biocomposite nanofibrous scaffolds for neural tissue engineering. Tissue Eng. A 14: 1787–1797, in Google Scholar PubMed

Qasim, S., Zafar, M., Najeeb, S., Khurshid, Z., Shah, A., Husain, S., and Rehman, I. (2018). Electrospinning of chitosan-based solutions for tissue engineering and regenerative medicine. Int. J. Mol. Sci. 19: 407, in Google Scholar PubMed PubMed Central

Qin, Z., Jia, X.-W., Liu, Q., Kong, B., and Wang, H. (2019). Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning nanofibers. Int. J. Biol. Macromol. 137: 224–231, in Google Scholar PubMed

Qin, Z., Jia, X., Liu, Q., Kong, B., and Wang, H. (2020). Enhancing physical properties of chitosan/pullulan electrospinning nanofibers via green crosslinking strategies. Carbohydr. Polym. 247: 116734, in Google Scholar PubMed

Ranjith, R., Balraj, S., Ganesh, J., and John Milton, M.C. (2019). Therapeutic agents loaded chitosan-based nanofibrous mats as potential wound dressings: a review. Mater. Today Chem. 12: 386–395, in Google Scholar

Rieger, K.A., Birch, N.P., and Schiffman, J.D. (2016). Electrospinning chitosan/poly(ethylene oxide) solutions with essential oils: correlating solution rheology to nanofiber formation. Carbohydr. Polym. 139: 131–138, in Google Scholar PubMed

Rošic, R., Pelipenko, J., Kocbek, P., Baumgartner, S., Bešter-Rogač, M., and Kristl, J. (2012). The role of rheology of polymer solutions in predicting nanofiber formation by electrospinning. Eur. Polym. J. 48: 1374–1384.10.1016/j.eurpolymj.2012.05.001Search in Google Scholar

Rwei, S.-P. and Huang, C.-C. (2012). Electrospinning PVA solution-rheology and morphology analyses. Fibers Polym. 13: 44–50, in Google Scholar

Saatchi, A., Razaghian, A., Moghanian, A., and Mozafari, M. (2020). Synthesis and characterization of electrospun cerium-doped bioactive glass/chitosan/polyethylene oxide composite scaffolds for tissue engineering applications. Ceram. Int. 47: 1–12, in Google Scholar

Sadri, M., Arab-Sorkhi, S., Vatani, H., and Bagheri-Pebdeni, A. (2015). New wound dressing polymeric nanofiber containing green tea extract prepared by electrospinning method. Fibers Polym. 16: 1742–1750, in Google Scholar

Sambudi, N.S., Sathyamurthy, M., Lee, G.M., and Park, S.B. (2015). Electrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineering. Compos. Sci. Technol. 106: 76–84, in Google Scholar

Sambudi, N.S., Kim, M.G., and Park, S.B. (2016). The formation of web-like connection among electrospun chitosan/PVA fiber network by the reinforcement of ellipsoidal calcium carbonate. Mater. Sci. Eng. C 60: 518–525, in Google Scholar PubMed

Sangsanoh, P. and Supaphol, P. (2006). Stability improvement of electrospun chitosan nanofibrous membranes in neutral or weak basic aqueous solutions. Biomacromolecules 7: 2710–2714, in Google Scholar PubMed

Schiffman, J.D. and Schauer, C.L. (2007). Cross-linking chitosan nanofibers. Biomacromolecules 8: 594–601, in Google Scholar PubMed

Schiffman, J.D. and Schauer, C.L. (2008). A review: electrospinning of biopolymer nanofibers and their applications. Polym. Rev. 48: 317–352, in Google Scholar

Semnani, D., Naghashzargar, E., Hadjianfar, M., Dehghan Manshadi, F., Mohammadi, S., Karbasi, S., and Effaty, F. (2017). Evaluation of PCL/chitosan electrospun nanofibers for liver tissue engineering. Int. J. Polym. Mater. Polym. Biomater. 66: 149–157, in Google Scholar

Shan, X., Li, F., Liu, C., and Gao, Q. (2014). Electrospinning of chitosan/poly(lactic acid) nanofibers: the favorable effect of nonionic surfactant. J. Appl. Polym. Sci. 131: 41098, in Google Scholar

Shariful, M.I., Sepehr, T., Mehrali, M., Ang, B.C., and Amalina, M.A. (2018). Adsorption capability of heavy metals by chitosan/poly(ethylene oxide)/activated carbon electrospun nanofibrous membrane. J. Appl. Polym. Sci. 135: 45851, in Google Scholar

Shekarforoush, E., Ajalloueian, F., Zeng, G., Mendes, A.C., and Chronakis, I.S. (2018). Electrospun xanthan gum-chitosan nanofibers as delivery carrier of hydrophobic bioactives. Mater. Lett. 228: 322–326, in Google Scholar

Shen, K., Hu, Q., Chen, L., and Shen, J. (2010). Preparation of chitosan bicomponent nanofibers filled with hydroxyapatite nanoparticles via electrospinning. J. Appl. Polym. Sci. 115: 2683–2690, in Google Scholar

Shenoy, S.L., Bates, W.D., Frisch, H.L., and Wnek, G.E. (2005). Role of chain entanglements on fiber formation during electrospinning of polymer solutions: good solvent, non-specific polymer–polymer interaction limit. Polymer 46: 3372–3384, in Google Scholar

Singh, Y.P., Dasgupta, S., Nayar, S., and Bhaskar, R. (2020). Optimization of electrospinning process & parameters for producing defect-free chitosan/polyethylene oxide nanofibers for bone tissue engineering. J. Biomater. Sci. Polym. Ed. 31: 781–803, in Google Scholar PubMed

Stoleru, E., Dumitriu, R.P., Munteanu, B.S., Zaharescu, T., Tănase, E.E., Mitelut, A., Ailiesei, G.-L., and Vasile, C. (2016). Novel procedure to enhance PLA surface properties by chitosan irreversible immobilization. Appl. Surf. Sci. 367: 407–417, in Google Scholar

Su, H., Liu, K.-Y., Karydis, A., Abebe, D.G., Wu, C., Anderson, K.M., Ghadri, N., Adatrow, P., Fujiwara, T., and Bumgardner, J.D. (2016). In vitro and in vivo evaluations of a novel post-electrospinning treatment to improve the fibrous structure of chitosan membranes for guided bone regeneration. Biomed. Mater. 12: 15003, in Google Scholar PubMed

Su, P., Wang, C., Yang, X., Chen, X., Gao, C., Feng, X.-X., Chen, J.-Y., Ye, J., and Gou, Z. (2011). Electrospinning of chitosan nanofibers: the favorable effect of metal ions. Carbohydr. Polym. 84: 239–246, in Google Scholar

Su, X., Wei, J., Ren, X., Li, L., Meng, X., Ren, J., and Tang, F. (2013). A new amperometric glucose biosensor based on one-step electrospun poly(vinyl alcohol)/chitosan nanofibers. J. Biomed. Nanotechnol. 9: 1776–1783, in Google Scholar PubMed

Sultankulov, B., Berillo, D., Sultankulova, K., Tokay, T., and Saparov, A. (2019). Progress in the development of chitosan-based biomaterials for tissue engineering and regenerative medicine. Biomolecules 9: 470, in Google Scholar PubMed PubMed Central

Sun, J., Perry, S.L., and Schiffman, J.D. (2019). Electrospinning nanofibers from chitosan/hyaluronic acid complex coacervates. Biomacromolecules 20: 4191–4198, in Google Scholar PubMed

Surendhiran, D., Li, C., Cui, H., and Lin, L. (2020). Fabrication of high stability active nanofibers encapsulated with pomegranate peel extract using chitosan/PEO for meat preservation. Food Packag. Shelf Life 23: 100439, in Google Scholar

Tiplea, R.E., Lemnaru, G.M., Trușcă, R.D., Holban, A., Kaya, M.G.A., Dragu, L.D., Ficai, D., Ficai, A., and Bleotu, C. (2021). Antimicrobial films based on chitosan, collagen, and zno for skin tissue regeneration. Biointerface Res. Appl. Chem. 11: 11985–11995.10.33263/BRIAC114.1198511995Search in Google Scholar

Torres‐Giner, S., Ocio, M.J., and Lagaron, J.M. (2008). Development of active antimicrobial fiber‐based chitosan polysaccharide nanostructures using electrospinning. Eng. Life Sci. 8: 303–314.10.1002/elsc.200700066Search in Google Scholar

Toskas, G., Cherif, C., Hund, R.-D., Laourine, E., Mahltig, B., Fahmi, A., Heinemann, C., and Hanke, T. (2013). Chitosan(PEO)/silica hybrid nanofibers as a potential biomaterial for bone regeneration. Carbohydr. Polym. 94: 713–722, in Google Scholar PubMed

Tsai, R.-Y., Kuo, T.-Y., Hung, S.-C., Lin, C.-M., Hsien, T.-Y., Wang, D.-M., and Hsieh, H.-J. (2015). Use of gum Arabic to improve the fabrication of chitosan–gelatin-based nanofibers for tissue engineering. Carbohydr. Polym. 115: 525–532, in Google Scholar PubMed

Tsaih, M.L. and Chen, R.H. (1997). Effect of molecular weight and urea on the conformation of chitosan molecules in dilute solutions. Int. J. Biol. Macromol. 20: 233–240, in Google Scholar PubMed

Vondran, J.L., Sun, W., and Schauer, C.L. (2008). Crosslinked, electrospun chitosan–poly(ethylene oxide) nanofiber mats. J. Appl. Polym. Sci. 109: 968–975, in Google Scholar

De Vrieze, S., Westbroek, P., Van Camp, T., and Van Langenhove, L. (2007). Electrospinning of chitosan nanofibrous structures: feasibility study. J. Mater. Sci. 42: 8029–8034, in Google Scholar

Wang, D., Cheng, W., Wang, Q., Zang, J., Zhang, Y., and Han, G. (2019). Preparation of electrospun chitosan/poly(ethylene oxide) composite nanofibers reinforced with cellulose nanocrystals: structure, morphology, and mechanical behavior. Compos. Sci. Technol. 182: 107774, in Google Scholar

Wang, D., Cheng, W., Yue, Y., Xuan, L., Ni, X., and Han, G. (2018a). Electrospun cellulose nanocrystals/chitosan/polyvinyl alcohol nanofibrous films and their exploration to metal ions adsorption. Polymers 10: 1046, in Google Scholar PubMed PubMed Central

Wang, D., Lu, Q., Wei, M., and Guo, E. (2018b). Ultrasmall Ag nanocrystals supported on chitosan/PVA nanofiber mats with bifunctional properties. J. Appl. Polym. Sci. 135: 46504, in Google Scholar

Wang, N., Wang, X., Jia, Y., Li, X., Yu, J., and Ding, B. (2014). Electrospun nanofibrous chitosan membranes modified with polyethyleneimine for formaldehyde detection. Carbohydr. Polym. 108: 192–199, in Google Scholar PubMed

Wang, P., Wang, L., Dong, S., Zhang, G., Shi, X., Xiang, C., and Li, L. (2018c). Adsorption of hexavalent chromium by novel chitosan/poly(ethylene oxide)/permutit electrospun nanofibers. New J. Chem. 42: 17740–17749, in Google Scholar

Wardhani, R.A.K., Asri, L.A.T.W., Rachmawati, H., Khairurrijal, K., and Purwasasmita, B.S. (2019). Stabilization of chitosan-polyethylene oxide electrospun nanofibrous containing Colocasia esculenta tuber protein. Mater. Res. Express 6: 1150f4, in Google Scholar

Wu, J. and Yin, F. (2013). Sensitive enzymatic glucose biosensor fabricated by electrospinning composite nanofibers and electrodepositing Prussian blue film. J. Electroanal. Chem. 694: 1–5, in Google Scholar

Wu, Y., Rashidpour, A., Almajano, M.P., and Metón, I. (2020). Chitosan-based drug delivery system: applications in fish biotechnology. Polymers 12: 1177, in Google Scholar PubMed PubMed Central

Xu, J., Zhang, J., Gao, W., Liang, H., Wang, H., and Li, J. (2009). Preparation of chitosan/PLA blend micro/nanofibers by electrospinning. Mater. Lett. 63: 658–660, in Google Scholar

Yang, D., Jin, Y., Ma, G., Chen, X., Lu, F., and Nie, J. (2008). Fabrication and characterization of chitosan/PVA with hydroxyapatite biocomposite nanoscaffolds. J. Appl. Polym. Sci. 110: 3328–3335, in Google Scholar

Ye, H., Zhu, J., Deng, D., Jin, S., Li, J., and Man, Y. (2019a). Enhanced osteogenesis and angiogenesis by PCL/chitosan/Sr-doped calcium phosphate electrospun nanocomposite membrane for guided bone regeneration. J. Biomater. Sci. Polym. Ed. 30: 1505–1522, in Google Scholar PubMed

Yao, R.S., You, Q.D., Liu, P.J., and Xu, Y.F. (2009). Synthesis and pH-induced phase transition behavior of PAA/PVA nanogels in aqueous media. J. Appl. Polym. Sci. 111: 358–362, doi:10.1002/app.29078.10.1002/app.29078Search in Google Scholar

Ye, Z., Zhang, B., Shao, L., Xing, G., Qi, C., and Tao, H. (2019b). Palladium nanoparticles embedded chitosan/poly(vinyl alcohol) composite nanofibers as an efficient and stable heterogeneous catalyst for Heck reaction. J. Appl. Polym. Sci. 136: 48026, in Google Scholar

Yee Kuen, C., Galen, T., Fakurazi, S., Othman, S.S., and Masarudin, M.J. (2020). Increased cytotoxic efficacy of protocatechuic acid in A549 human lung cancer delivered via hydrophobically modified-chitosan nanoparticles as an anticancer modality. Polymers 12: 1951, in Google Scholar PubMed PubMed Central

Yousefi, I., Pakravan, M., Rahimi, H., Bahador, A., Farshadzadeh, Z., and Haririan, I. (2017). An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering. Mater. Sci. Eng. C 75: 433–444, in Google Scholar PubMed

Yu, R., Cornette de Saint-Cyr, L., Soussan, L., Barboiu, M., and Li, S. (2021). Anti-bacterial dynamic hydrogels prepared from O-carboxymethyl chitosan by dual imine bond crosslinking for biomedical applications. Int. J. Biol. Macromol. 167: 1146–1155, in Google Scholar PubMed

Zarghami, A., Irani, M., Mostafazadeh, A., Golpour, M., Heidarinasab, A., and Haririan, I. (2015). Fabrication of PEO/chitosan/PCL/olive oil nanofibrous scaffolds for wound dressing applications. Fibers Polym. 16: 1201–1212, in Google Scholar

Zhang, C., Yuan, X., Wu, L., Han, Y., and Sheng, J. (2005). Study on morphology of electrospun poly(vinyl alcohol) mats. Eur. Polym. J. 41: 423–432, in Google Scholar

Zhang, Y., Huang, X., Duan, B., Wu, L., Li, S., and Yuan, X. (2007). Preparation of electrospun chitosan/poly(vinyl alcohol) membranes. Colloid Polym. Sci. 285: 855–863, in Google Scholar

Zhang, Y., Venugopal, J.R., El-Turki, A., Ramakrishna, S., Su, B., and Lim, C.T. (2008). Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering. Biomaterials 29: 4314–4322, in Google Scholar PubMed

Zhao, R., Li, X., Sun, B., Zhang, Y., Zhang, D., Tang, Z., Chen, X., and Wang, C. (2014). Electrospun chitosan/sericin composite nanofibers with antibacterial property as potential wound dressings. Int. J. Biol. Macromol. 68: 92–97, in Google Scholar PubMed

Zhou, Y., Yang, D., and Nie, J. (2006). Electrospinning of chitosan/poly(vinyl alcohol)/acrylic acid aqueous solutions. J. Appl. Polym. Sci. 102: 5692–5697, in Google Scholar

Zhou, Y.S., Yang, D.Z., and Nie, J. (2007). Effect of PVA content on morphology, swelling and mechanical property of crosslinked chitosan/PVA nanofibre. Plast. Rubber Compos. Macromol. Eng. 36: 254–258, in Google Scholar

Zhu, X., Chian, K.S., Chan-Park, M.B.E., and Lee, S.T. (2005). Effect of argon-plasma treatment on proliferation of human-skin-derived fibroblast on chitosan membrane in vitro. J. Biomed. Mater. Res. A 73A: 264–274, in Google Scholar PubMed

Zhuang, X., Cheng, B., Kang, W., and Xu, X. (2010). Electrospun chitosan/gelatin nanofibers containing silver nanoparticles. Carbohydr. Polym. 82: 524–527, in Google Scholar

Ziani, K., Henrist, C., Jérôme, C., Aqil, A., Maté, J.I., and Cloots, R. (2011). Effect of nonionic surfactant and acidity on chitosan nanofibers with different molecular weights. Carbohydr. Polym. 83: 470–476, in Google Scholar

Zong, X., Kim, K., Fang, D., Ran, S., Hsiao, B.S., and Chu, B. (2002). Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer 43: 4403–4412, in Google Scholar

Zuo, F.F., Cheng, B.W., Kang, W.M., and Ma, Y.H. (2011). Preparation of chitosan/poly(vinyl alcohol) blend nanofibers containing Ag–SiO2 nanoparticles via electrospinning. Mater. Sci. Forum 675: 271–274, in Google Scholar

Received: 2021-01-19
Accepted: 2021-06-04
Published Online: 2021-07-30
Published in Print: 2023-01-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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