Accessible Unlicensed Requires Authentication Published by De Gruyter September 12, 2015

The implications of non-linear biological oscillations on human electrophysiology for electrohypersensitivity (EHS) and multiple chemical sensitivity (MCS)

Cindy Sage

Abstract

The ‘informational content’ of Earth's electromagnetic signaling is like a set of operating instructions for human life. These environmental cues are dynamic and involve exquisitely low inputs (intensities) of critical frequencies with which all life on Earth evolved. Circadian and other temporal biological rhythms depend on these fluctuating electromagnetic inputs to direct gene expression, cell communication and metabolism, neural development, brainwave activity, neural synchrony, a diversity of immune functions, sleep and wake cycles, behavior and cognition. Oscillation is also a universal phenomenon, and biological systems of the heart, brain and gut are dependent on the cooperative actions of cells that function according to principles of non-linear, coupled biological oscillations for their synchrony. They are dependent on exquisitely timed cues from the environment at vanishingly small levels. Altered ‘informational content’ of environmental cues can swamp natural electromagnetic cues and result in dysregulation of normal biological rhythms that direct growth, development, metabolism and repair mechanisms. Pulsed electromagnetic fields (PEMF) and radiofrequency radiation (RFR) can have the devastating biological effects of disrupting homeostasis and desynchronizing normal biological rhythms that maintain health. Non-linear, weak field biological oscillations govern body electrophysiology, organize cell and tissue functions and maintain organ systems. Artificial bioelectrical interference can give false information (disruptive signaling) sufficient to affect critical pacemaker cells (of the heart, gut and brain) and desynchronize functions of these important cells that orchestrate function and maintain health. Chronic physiological stress undermines homeostasis whether it is chemically induced or electromagnetically induced (or both exposures are simultaneous contributors). This can eventually break down adaptive biological responses critical to health maintenance; and resilience can be compromised. Electrohypersensitivity can be caused by successive assaults on human bioelectrochemical dynamics from exogenous electromagnetic fields (EMF) and RFR or a single acute exposure. Once sensitized, further exposures are widely reported to cause reactivity to lower and lower intensities of EMF/RFR, at which point thousand-fold lower levels can cause adverse health impacts to the electrosensitive person. Electrohypersensitivity (EHS) can be a precursor to, or linked with, multiple chemical sensitivity (MCS) based on reports of individuals who first develop one condition, then rapidly develop the other. Similarity of chemical biomarkers is seen in both conditions [histamines, markers of oxidative stress, auto-antibodies, heat shock protein (HSP), melatonin markers and leakage of the blood-brain barrier]. Low intensity pulsed microwave activation of voltage-gated calcium channels (VGCCs) is postulated as a mechanism of action for non-thermal health effects.


Corresponding author: Cindy Sage, MA, Sage Associates, 1396 Danielson Road, Santa Barbara, CA, 93108 USA, Phone: +805 969-0557, E-mail:

References

1. Buzsaki G. Rhythms of the Brain. New York: Oxford University Press, 2006. Search in Google Scholar

2. Strogatz SH. Sync: the emerging science of spontaneous order. New York: Hyperion, 2003. Search in Google Scholar

3. Herbert MR, Sage C. Autism and EMF? Plausibility of a pathophysiological link- part II. Pathophysiology 2013;20: 211–34. Search in Google Scholar

4. Berridge MJ, Galione A. Cytosolic calcium oscillators. FASEB J 1988;2:3074–82. Search in Google Scholar

5. Pilla AA. Nonthermal electromagnetic fields: from first messenger to therapeutic applications. Electromagn Biol Med 2013;32:123–36. Search in Google Scholar

6. Pilla AA. Pulsed electromagnetic fields: from signaling to healing. In: Markov MS, editor. Electromagnetic fields in biology and medicine. Boca Raton: CPC Press, 2015:29–48. Search in Google Scholar

7. Pall ML. Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects. J Cell Mol Med 2013;17:958–65. Search in Google Scholar

8. Pall ML. Electromagnetic field activation of voltage-gated calcium channels: role in therapeutic effects. Electromag Biol Med 2014;33:251. Search in Google Scholar

9. Pall ML. Scientific evidence contradicts findings and assumptions of Canadian Safety Panel 6: microwaves act through voltage-gated calcium channel activation to induce biological impacts at non-thermal levels, supporting a paradigm shift for microwave/lower frequency electromagnetic field action. Rev Environ Health 2015;30:99–116. Search in Google Scholar

10. Sage C, Johansson O, Sage SA. Personal digital assistant (PDA) cell phone units produce elevated extremely-low frequency electromagnetic field emissions. Bioelectromagnetics 2007;28:386–92. Search in Google Scholar

11. Belpomme D, Irigaray P. Electrohypersensitivity and multiple chemical sensitivity: two clinic-biological entities of the same disorder? Conference presentation, Paris Appeal Congress May 18, 2015 at the Royal Academy of Medicine, Brussels, Belgium. Search in Google Scholar

12. Adey WR. A growing scientific consensus on the cell and molecular biology mediating interactions with EM fields, Symposium Electromagnetic Transmissions, Health Hazards, Scientific Evidence and Recent Steps in Mitigation, 1994. Search in Google Scholar

13. Strogatz SH. Exploring complex networks. Nature 2001;410:266–76. Search in Google Scholar

14. Strogatz SH, Kronauer RE, Czeisler CA. Circadian pacemaker interferes with sleep onset at specific times each day: role in insomnia. Am J Physiol 1987;253:R172–8. Search in Google Scholar

15. Iotti S, Borsari M, Bendahan D. Oscillations in energy metabolism. Biochim Biophys Acta 2010;1797:1353–61. Search in Google Scholar

16. Hinrikus H, Bachmann M, Lass J, Tomson R, Tuulik V. Effect of 7, 14 and 21 Hz modulated 450 MHz microwave radiation on human electroencephalographic rhythms. Int J Radiat Biol 2008:84:69–79. Search in Google Scholar

17. Marino AA, Nilsen E, Frilot C. Nonlinear changes in brain electrical activity due to cell phone radiation. Bioelectromagnetics 2003;24:339–46. Search in Google Scholar

18. Marino AA, Carrubba S. The effects of mobile-phone electromagnetic fields on brain electrical activity: a critical analysis of the literature. Electromagn Biol Med 2009;28:250–74. Search in Google Scholar

19. Vecchio F, Babiloni C, Ferreri F, Curcio G, Fini R, et al. Mobile phone emission modulates interhemispheric functional coupling of EEG alpha rhythms. Eur J Neurosci 2007;25:1908–13. Search in Google Scholar

20. Vecchio F, Tombini M, Buffo P, Assenza G, Pellegrino G, et al. Mobile phone emission increases inter-hemispheric functional coupling of electroencephalographic alpha rhythms in epileptic patients. Int J Psychophysiol 2012;84:164–71. Search in Google Scholar

21. Tattersall JE, Scott IR, Wood SJ, Nettell JJ, Bevir MK, et al. Effects of low intensity radiofrequency electromagnetic fields on electrical activity in rat hippocampal slices. Brain Res 2001;904:43–53. Search in Google Scholar

22. Hountala CD, Maganioti AE, Papageorgiou CC, Nanou ED, Kyprianou MA, et al. The spectral power coherence of the EEG under different EMF conditions. Neurosci Lett 2008;441:188–92. Search in Google Scholar

23. Bachmann M, Lass J, Kalda J, Sakki M, Tomson R, et al. Integration of differences in EEG analysis reveals changes in human EEG caused by microwave. Conf Proc IEEE Eng Med Biol Soc 2006;1:1597–600. Search in Google Scholar

24. Johansson O. Disturbance of the immune system by electromagnetic fields – a potentially underlying cause for cellular damage and tissue repair reduction which could lead to disease and impairment. Pathophysiology 2009;16:157–77. Search in Google Scholar

25. Johannson O. Evidence for effects on immune function. In: Sage C, Carpenter DO, editors. BioInitiative report: a rationale for a biologically-based public exposure standard for electromagnetic fields (ELF and RF). Available at: http://bioinitiative.org/freeaccess/report/index.htm. Search in Google Scholar

26. Seitz H, Stinner D, Eikmann T, Herr C, Roosli M. Electromagnetic hypersensitivity (EHS) and subjective health complaints associated with electromagnetic fields of mobile phone communication – a literature review published between 2000 and 2004. Sci Total Environ 2005;349:45–55. Search in Google Scholar

27. Johansson O, Gangi S, Liang Y, Yoshimura K, Jing C, et al. Cutaneous mast cells are altered in normal healthy volunteers sitting in front of ordinary TVs/PCs – results from open-field provocation experiments. J Cutan Pathol 2001;28:513–9. Search in Google Scholar

28. Buchner K, Eger H. Changes of clinically important neurotransmitters under the Influence of modulated RF fields – a long-term study under real-life conditions (translated; original study in German). Umwelt-Medizin-Gesellschaft 2011;24:44–57. Search in Google Scholar

29. Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, et al. Mast cell activation and autism. Biochim Biophys Acta 2012;1822(1):34–41. Search in Google Scholar

30. Zhang B, Asadi S, Weng Z, Sismanopoulos N, Theoharides TC. Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions. PLoS One 2012;7:e49767. Search in Google Scholar

31. Salford LG, Nittby H, Persson BR. Effects of EMF from wireless communication upon the blood–brain barrier. In: Sage C, Carpenter DO, editors. The BioInitiative report 2012: a rationale for a biologically-based public exposure standard for electromagnetic fields (ELF and RF). Available at: http://www.bioinitiative.org. Search in Google Scholar

32. Aldad TS, Gan G, Gao XB, Taylor HS. Fetal radiofrequency radiation exposure from 800–1900 MHz-rated cellular telephones affects neurodevelopment and behavior in mice. Sci Rep 2012;2:312. Search in Google Scholar

33. Divan HA, Kheifets L, Obel C, Olsen J. Prenatal and postnatal exposure to cell phone use and behavioral problems in children. Epidemiology 2008;19:523–9. Search in Google Scholar

34. Kenet T. Sensory functions in ASD. In: Fein D, editor. The neuropsychology of autism. New York: Oxford University Press, 2011:215–24. Search in Google Scholar

35. Kenet G, Froemke RC, Schreiner CE, Pessah IN, Merzenich MM. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex. Proc Natl Acad Sci USA 2007;104:7646–51. Search in Google Scholar

36. Pessah IN, Lein PJ. Evidence for environmental susceptibility in autism. What we need to know about gene x environment interactions. In: Zimmerman AW, ed. Austim: Current Theories and Evidence. Totowa, NJ: Humana Press, 2008, Chapter 19, pp. 409–428. Search in Google Scholar

37. Stamou M, Streifel KM, Goines PE, Lein PJ. Neuronal connectivity as a convergent target of gene-environment interactions that confer risk for autism spectrum disorders. Neurotoxicol Teratol 2013;36:3–16. Search in Google Scholar

38. Zhang LI, Bao, S Merzenich M. Disruption of primary auditory cortex by synchronous auditory inputs during a critical period. Proc Natl Acad Sci USA2002;99:2309–14. Search in Google Scholar

39. Narayanan SN, Kumar RS, Kedage V, Nalini K, Nayak S, et al. Evaluation of oxidant stress and antioxidant defense in discrete brain regions of rats exposed to 900 MHz radiation. Bratisl Lek Listy 2014;115:260–6. Search in Google Scholar

40. Maskey D, Kim MJ. Immunohistochemical localization of brain-derived neutrophic factor and glial cell line-derived neurotrophic factor in the superior olivary complex of mice after radiofrequency exposure. Neurosci Lett 2014;564:1–18. Search in Google Scholar

41. Mann K, Roschke J. Effects of pulsed high-frequency electromagnetic fields on human sleep. Neuropsychobiology 1996;33:41–7. Search in Google Scholar

42. Borbely AA, Huber R, Graf T, Fuchs B, Gallmann E, et al. Pulsed high-frequency electromagnetic field affects human sleep and sleep electroencephalogram. Neurosci Lett 1999;275:207–10. Search in Google Scholar

43. Huber R, Schuderer J, Graf T, Jutz K, Borbely AA, et al. Radio frequency electromagnetic field exposure in humans: estimation of SAR distribution in the brain, effects on sleep and heart rate. Bioelectromagnetics 2003;24:262–76. Search in Google Scholar

44. Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, et al. Wakefulness Is governed by GABA and histamine cotransmission. Neuron 2015;87:164–78. Search in Google Scholar

45. Leon J, Acuna-Castroviejo D, Escames G, Tan DX, Reiter RF. Melatonin mitigates mitochondrial malfunction. J Pineal Res 2005;38:1–9. Search in Google Scholar

46. Luchetti F, Canonico B, Betti M, Arcangeletti M, Pilolli F, et al. Melatonin signaling and cell protection function. FASEB J 2010;24:3603–24. Search in Google Scholar

47. Limon-Pacheco JH, Gonsebatt ME. The glutathione system and its regulation by neurohormone melatonin in the central nervous system. Cent Nerv Syst Agents Med Chem 2010;10:287–97. Search in Google Scholar

48. Hardeland R. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 2005;27:119–30. Search in Google Scholar

49. Gupta YK, Gupta M, Kohli K. Neuroprotective role of melatonin in oxidative stress vulnerable brain. Indian J Physiol Pharmacol 2003;47:373–86. Search in Google Scholar

50. Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, et al. Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry 2012;2:e134. Search in Google Scholar

51. Juutilainen J, Kumlin T. Occupational magnetic field exposure and melatonin: interaction with light-at-night. Bioelectromagnetics 2006;27:423–6. Search in Google Scholar

52. Juutilainen J, Kumlin T, Naarala J. Do extremely low frequency magnetic fields enhance the effects of environmental carcinogens? A meta-analysis of experimental studies. Int J Radiat Biol 2006;82:1–12. Search in Google Scholar

53. Verschaeve L, Heikkinen P, Verheyen G, Van Gorp U, Boonen F, et al. Investigation of co-genotoxic effects of radiofrequency electromagnetic fields in vivo. Radiat Res 2006;165:598–607. Search in Google Scholar

54. Ahlbom A, Bridges J, de Seze R, Hillert L, Juutilainen J, et al. Possible effects of electromagnetic fields (EMF) on human health – opinion of the scientific committee on emerging and newly identified health risks (SCENIHR). Toxicology 2008;246:248–50. Search in Google Scholar

55. Hoyto A, Luukkonen J, Juutilainen J, Naarala J. Proliferation, oxidative stress and cell death in cells exposed to 872 MHz radiofrequency radiation and oxidants. Radiat Res 2008;170:235–43. Search in Google Scholar

56. Juutilainen J. Do electromagnetic fields enhance the effects of environmental carcinogens? Radiat Prot Dosimetry 2008;132:228–31. Search in Google Scholar

57. Luukkonen J, Hakulinen P, Maki-Paakkanen J, Juutilainen J, Naarala H. Enhancement of chemically induced reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells by 872 MHz radiofrequency radiation. Mutat Res 2009;662:54–8. Search in Google Scholar

58. Markkanen A, Juutilainen J, Naarala J. Pre-exposure to 50 Hz magnetic fields modifies menadione-induced DNA damage response in murine L929 cells. Int J Radiat Biol 2008;84:742–51. Search in Google Scholar

Received: 2015-5-6
Accepted: 2015-7-30
Published Online: 2015-9-12
Published in Print: 2015-12-1

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