Aim: Exposure assessment of lead (Pb) and Arsenic (As) from food, water, and house dust intake were assessed among pregnant women, their children and fetuses in Pakistan and Japan, as well as their body burden of the metals in their blood.
Method: Fifty families which included a pregnant woman, a fetus and the 1–3-year-old siblings were recruited in Karachi and Khairpur in Pakistan, and Shimotsuke and Asahikawa in Japan, respectively. Their dietary exposure to Pb and As was measured in 3-day food duplicates and drinking water by ICP-MP. Pb in house dust and respirable dust was evaluated with an energy dispersive X-ray fluorescence spectrometry. Non-radioactive isotope Pb profiles of blood specimens will be compared with those of the exposure origins, such as food duplicates, respirable house dust, the soils nearby, and gasoline.
Results: Judging from the data collected and analyzed so far, contribution from dietary intake is highly correlated to higher body burden of Pb among Pakistani mothers. Additional data analyses will reveal the status of Pb and As body burden in Pakistani mothers, fetuses and their siblings, and causal sources of high body burden is delineated by Pb isotope profile analysis of different sources of Pb exposure.
1. Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, et al. Low-level environmental lead exposure and children’s intellectual function: an international pooled analysis. Environ Health Perspect 2005;113(7):894–9.10.1289/ehp.7688Search in Google Scholar PubMed PubMed Central
2. Bellinger DC. What is an adverse effect? A possible resolution of clinical and epidemiological perspectives on neurobehavioral toxicity. Environ Res 2004;95:394–405.10.1016/j.envres.2003.07.013Search in Google Scholar PubMed
3. Domingo JL, Perelló G, Giné Bordonaba J. Dietary intake of metals by the population of tarragona county (Catalonia, Spain): results from a duplicate diet study. Biol Trace Elem Res 2012;146(3):420–5.10.1007/s12011-011-9269-5Search in Google Scholar PubMed
4. Lanphear BP, Hornung R, Ho M, Howard CR, Eberly S, et al. Environmental lead exposure during early childhood. J Pediatr 2002;140(1):40–7.10.1067/mpd.2002.120513Search in Google Scholar PubMed
5. Kapaj S, Peterson H, Liber K, Bhattacharya P. Human health effects from chronic arsenic poisoning – A review. J Environ Sci Health A Tox Hazard Subst Environ Eng 2006;41(10):2399–428.10.1080/10934520600873571Search in Google Scholar PubMed
6. Schuhmacher-Wolz U, Dieter HH, Klein D, Schneider K. Oral exposure to inorganic arsenic: evaluation of its carcinogenic and non-carcinogenic effects. Crit Rev Toxicol 2009;39(4):271–98.10.1080/10408440802291505Search in Google Scholar PubMed
7. Kadir MM, Janjua NZ, Kristensen S, Fatmi Z, Sathiakumar N. Status of children’s blood lead levels in Pakistan: implications for research and policy. Public Health 2008;122(7):708–15.10.1016/j.puhe.2007.08.012Search in Google Scholar PubMed PubMed Central
8. Iqbal MP. Lead pollution – A risk factor for cardiovascular disease in Asian developing countries. Pak J Pharm Sci 2012;25(1):289–94.Search in Google Scholar
9. Fatmi Z, Abbasi IN, Ahmed M, Kazi A, Kayama F. Burden of skin lesions of arsenicosis at higher exposure through groundwater of taluka Gambat district Khairpur, Pakistan: a cross-sectional survey. Environ Geochem Health 2013;35(3):341–6.10.1007/s10653-012-9498-3Search in Google Scholar PubMed
10. Hedrick VE, Dietrich AM, Estabrooks PA, Savla J, Serrano E, et al. Dietary biomarkers: advances, limitations and future directions. Nutr J 2012;11:109–12.10.1186/1475-2891-11-109Search in Google Scholar PubMed PubMed Central
11. Schecter A, Päpke O, Harris TR, Tung KC, Musumba A, et al. Polybrominated diphenyl ether (PBDE) levels in an expanded market basket survey of U.S. food and estimated PBDE dietary intake by age and sex. Environ Health Perspect 2006;114(10):1515–20.10.1289/ehp.9121Search in Google Scholar PubMed PubMed Central
12. Zahir E, Naqvi IM, Mohi Uddin S. Market basket survey of selected metals in fruits from Karachi city (Pakistan). J Basic Appl Sci 2009;5(2):47–52.Search in Google Scholar
13. Rahbar MH, White F, Agboatwalla M, Hozhabri S, Luby S. Factors associated with elevated blood lead concentrations in children in Karachi, Pakistan. Bull World Health Organ 2002;80:769–75.Search in Google Scholar
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