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Licensed Unlicensed Requires Authentication Published by De Gruyter August 27, 2020

Effect of occupational exposure to petrol and gasoline components on liver and renal biochemical parameters among gas station attendants, a review and meta-analysis

  • Somayeh Rahimi Moghadam , Mahdi Afshari , Ali Ganjali and Mahmood Moosazadeh EMAIL logo



Kidney and liver are of the most affected organs during permanent exposure to petrol and gasoline components in gas stations. This study aims to investigate the renal and liver involvements in these workers using meta-analysis.


PubMed, Scopus, Science direct, ISI web of science, and Google scholar motor engine were searched using Mesh terms of the relevant keywords. Screening of titles, abstracts and full texts was continued until the eligible articles meeting the inclusion/exclusion criteria were selected. Quality assessment was conducted using NOS (Newcastle–Ottawa Quality score). The pooled standard mean difference of the renal and liver indices between exposed/unexposed groups was estimated using Stata ver. 11 software.


In this systematic review, 22 papers were entered. The pooled standard mean difference (95% confidence interval) between exposed and unexposed groups was estimated as of 0.74 (0.28, 1.21) for alkaline phosphatase (ALP), 2.44 (1.80, 3.08) for aspartate transaminase (AST), 2.06 (1.42, 2.69) for alanine transaminase (ALT), 0.10 (−0.09, 0.29) for total Bilirubin (TB), 0.74 (−0.42, −1.90) for total protein (TP), −0.49 (−0.82, −0.15) for albumin, 0.88 (−0.10, 1.87) for uric acid, 1.02 (0.45, 1.59) for creatinine and 1.44 (0.75, 2.13) for blood urea nitrogen (BUN).


Our meta-analysis showed that the serum AST, ALT, ALP, total protein, total bilirubin, BUN, uric acid and creatinine levels were higher among workers exposed to petrol and gasoline than control group, while albumin was lower in the serum of the exposed workers. Therefore, occupational exposure to gasoline stations can create adverse effects on kidney and liver function.

Corresponding author: Mahmood Moosazadeh, Assistant Professor, Health Science Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: None declared.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


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Supplementary material

The online version of this article offers supplementary material (

Received: 2019-12-26
Accepted: 2020-06-02
Published Online: 2020-08-27
Published in Print: 2020-11-18

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