Abstract
The health risks brought by particles cannot be present via a sole parameter. Instead, the particulate matter oxidative potential (PM OP), which expresses combined redox properties of particles, is used as an integrated metric to assess associated hazards and particle-induced health effects. OP definition provides the capacity of PM toward target oxidation. The latest technologies of a cellular OP measurement has been growing in relevant studies. In this review, OP measurement techniques are focused on discussing along with PM characterization because of many related studies via OP measurements investigating relationship with human health. Many OP measurement methods, such as dithiothreitol (DTT), ascorbic acid (AA), glutathione (GSH) assay and other a cellular assays, are used to study the association between PM toxicity and PM characterization that make different responses, including PM components, size and sources. Briefly, AA and DTT assays are sensitive to metals (such as copper, manganese and iron etc.) and organics (quinones, VOCs and PAH). Measured OP have significant association with certain PM-related end points, for example, lung cancer, COPD and asthma. Literature has found that exposure to measured OP has higher risk ratios than sole PM mass, which may be containing the PM health-relevant fraction. PM characterization effect on health via OP measurement display a promising method.
Funding source: Education and scientific research project for young and middle-aged teachers in Fujian Province
Award Identifier / Grant number: JAT190651
Funding source: Fujian Science and Technology Guiding Project
Award Identifier / Grant number: 2018Y0079
Funding source: Fujian Engineering and Research Center of Rural Sewage Treatment and Water Safety, and Key Laboratory of Environmental Biotechnology (XMUT), Fujian Province University
Funding source: The Research Foundation for Advanced Talents in Xiamen University of Technology
Award Identifier / Grant number: YKJ19027R
Research funding: The authors gratefully thank the Research Foundation for Advanced Talents in Xiamen University of Technology (No. YKJ19027R), Education and scientific research project for young and middle-aged teachers in Fujian Province (No. JAT190651), Fujian Science and Technology Guiding Project (2018Y0079), Fujian Engineering and Research Center of Rural Sewage Treatment and Water Safety, and Key Laboratory of Environmental Biotechnology (XMUT), Fujian Province University.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Competing interests: Authors state no conflicts of interest.
Informed consent and ethical approval: are mandatory for original research that involved human or animal subject.
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