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Accessible Unlicensed Requires Authentication Published by De Gruyter December 10, 2020

Pesticide applicators and cancer: a systematic review

Jean V. Varghese, Elveena M. Sebastian, Thamanna Iqbal and Antriya A. Tom

Abstract

The objective of the study was to identify and analyse the research done on the occurrence of cancer among pesticide applicators by conducting a systematic review of the scientific literature. PRISMA Guidelines was followed to conduct the study. Search was done in Scopus, PubMed, Embase, MEDLINE and Google Scholar databases with search terms “PESTICIDE APPLICATORS”, “CANCER” using Boolean operator “AND”. Meta-analysis and review articles were excluded from the study. A total of 32 studies were identified among which the average sample size was found to be 60,521. Increased RRs/ORs and positive exposure–response relationships were observed for 31 pesticides. Organophosphate and organochlorine classes of pesticides were the most to be associated with cancer. Lung cancer was observed the most followed by prostate, multiple myeloma and colon cancers among pesticide applicators. It was concluded that there is an increased risk of cancer among the pesticide applicators, whereby which bringing into focus the need to educate and train the workers on following adequate safety measures and making them aware of the hazardous chemicals. Further evaluation on the carcinogenicity of pesticides is also required.


Corresponding author: Antriya A. Tom, Department of Pharmacy Practice, Nirmala College of Pharmacy, 686661, Muvattupuzha, Kerala, India, Phone: +0091 9567884407, E-mail:

Acknowledgment

Sincere thanks to God the Almighty, colleagues and faculties of Nirmala College of Pharmacy, Kerala, India.

  1. Research funding: Authors state no funding involved.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent is not applicable.

  5. Ethical approval: The conducted research is not related to either human or animal use.

References

1. Alavanja, MC. Pesticides use and exposure extensive worldwide. Rev Environ Health 2010;24:303–9.Search in Google Scholar

2. Californians For Pesticide Reform. Pesticides and human health. Available from: .Search in Google Scholar

3. Jaga, K, Dharmani, C. The epidemiology of pesticide exposure and cancer: a review. Rev Environ Health 2005;20. https://doi.org/10.1515/reveh.2005.20.1.15.Search in Google Scholar

4. National Cancer Control Policy. Position statement-pesticide and cancer. Available from: .Search in Google Scholar

5. Current Intelligent Bulletin. Update of NIOSH carcinogen classification and target risk level policy for chemical hazards in the workplace. Available from: .Search in Google Scholar

6. National Toxicology Program. Science you can depend on for decisions that matter. Available from: .Search in Google Scholar

7. National Toxicology Program. 14th report on carcinogens. Available from: .Search in Google Scholar

8. Wikipedia. United states environmental protection agency. Available from: .Search in Google Scholar

9. International Agency for Research on Cancer. Agents classified by the IARC monographs, Volumes 1-127. Available from: .Search in Google Scholar

10. Roos, A, Blair, A, Rusiecki, J, Hoppin, J, Svec, M, Dosemeci, M, et al.. Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. Environ Health Perspect 2005;113:49–54. https://doi.org/10.1289/ehp.7340.Search in Google Scholar

11. Kang, D, Park, SK, Beane-Freeman, L, Lynch, CF, Knott, CE, Sandler, D, et al.. Cancer incidence among pesticide applicators exposed to trifluralin in the Agricultural Health Study. Environ Res 2008;107:271–6. https://doi.org/10.1016/j.envres.2008.01.010.Search in Google Scholar

12. Samanic, C, Rusiecki, J, Dosemeci, M, Hou, L, Hoppin, JA, Sandler, DP, et al.. Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health study. Environ Health Perspect 2006;114:1521–6. https://doi.org/10.1289/ehp.9204.Search in Google Scholar

13. Alavanja, MCR, Samanic, C, Dosemeci, M, Lubin, J, Tarone, R, Lynch, CF, et al.. Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol 2003;157:800–14. https://doi.org/10.1093/aje/kwg040.Search in Google Scholar

14. Bemmel, DM, Visvanathan, K, Beane Freeman, LE, Coble, J, Hoppin, JA, Alavanja, MCR, et al.. N-dipropylthiocarbamte exposure and cancer incidence among male pesticide applicators in the agricultural health study: a prospective cohort. Environ Health Perspect 2008;116:1541–6. https://doi.org/10.1289/ehp.11371.Search in Google Scholar

15. Freeman, LB, Bonner, MR, Blair, A, Hoppin, JA, Sandler, DP, Lubin, JH, et al.. Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon. Am J Epidemiol 2005;162:1070–9. https://doi.org/10.1093/aje/kwi321.Search in Google Scholar

16. Dennis, LK, Lynch, CF, Sandler, DP, Alavanja, MCR. Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural health study. Environ Health Perspect 2010;118:812–7. https://doi.org/10.1289/ehp.0901518.Search in Google Scholar

17. Park, SK, Kang, D, Freeman, LB, Blair, A, Hoppin, JA, Sandler, DP, et al.. Cancer incidence among paraquat exposed applicators in the Agricultural Health Study: a prospective cohort study. Int J Occup Environ Health 2009;15:274–81. https://doi.org/10.1179/oeh.2009.15.3.274.Search in Google Scholar

18. Andreotti, G, Freeman, LB, Hou, L, Coble, J, Rusiecki, J, Hoppin, JA, et al.. Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort. Int J Canc 2009;124:2495–500. https://doi.org/10.1002/ijc.24185.Search in Google Scholar

19. Freeman, LB, Rusiecki, JA, Hoppin, JA, Lubin, JH, Koutros, S, Andreotti, G, et al.. Atrazine and cancer incidence among pesticide applicators in the Agricultural Health Study. Environ Health Perspect 2011;119:1253–9. https://doi.org/10.1289/ehp.1103561.Search in Google Scholar

20. Koutros, S, Freeman, LB, Lubin, JH, Heltshe, SL, Andreotti, G, Barry, KH, et al.. Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study. Am J Epidemiol 2013;177:59–74. https://doi.org/10.1093/aje/kws225.Search in Google Scholar

21. Rusiecki, JA, Patel, R, Koutros, S, Freeman, LB, Landgren, O, Bonner, MR, et al.. Cancer incidence among pesticide applicators exposed to permethrin in the Agricultural Health Study. Environ Health Perspect 2009;117:581–6. https://doi.org/10.1289/ehp.11318.Search in Google Scholar

22. Bonner, MR, Freeman, LB, Hoppin, JA, Koutros, S, Sandler, DP, Lynch, CF, et al.. Occupational exposure to pesticides and the incidence of lung cancer in the agricultural health study. Environ Health Perspect 2007;125:544–51.10.1289/EHP456Search in Google Scholar

23. Rusiecki, JA, Hou, L, Lee, WJ, Blair, A, Dosemeci, M, Lubin, JH, et al.. Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health Study. Int J Canc 2006;118:3118–23. https://doi.org/10.1002/ijc.21758.Search in Google Scholar

24. Barry, KH, Koutros, S, Lubin, JH, Coble, JB, Adesi, FB, Freeman, LB, et al.. Methyl bromide exposure and cancer risk in the Agricultural Health Study. Canc Causes Contr 2012;23:807–18. https://doi.org/10.1007/s10552-012-9949-2.Search in Google Scholar

25. Lee, WJ, Sandler, DP, Blair, A, Samanic, C, Cross, AJ, Alavanja, MCR. Pesticide use and colorectal cancer risk in the Agricultural Health Study. Int J Canc 2007;121:339–46. https://doi.org/10.1002/ijc.22635.Search in Google Scholar

26. Lynch, SM, Mahajan, R, Freeman, LB, Hoppin, JA, Alavanja, MCR. Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS). Environ Res 2009;109:860–8. https://doi.org/10.1016/j.envres.2009.06.006.Search in Google Scholar

27. Barthel, E. Increased risk of lung cancer in pesticide-exposed male agricultural workers. J Toxicol Environ Health 1981;8:1027–40. https://doi.org/10.1080/15287398109530135.Search in Google Scholar

28. Hazarika, M, Hazarika, R. Pesticide exposure and cancers in Barpeta district, Assam- A case for control study. Nat Environ Pollut Technol 2013;12:467–70.Search in Google Scholar

29. Koutros, S, Lynch, CF, Ma, X, Lee, WJ, Hoppin, JA, Christensen, CH, et al.. Heterocyclic aromatic amine pesticide use and human cancer risk: results from the US Agricultural Health Study. Int J Canc 2009;124:1206–12. https://doi.org/10.1002/ijc.24020.Search in Google Scholar

30. Lerro, CC, Koutros, S, Androtti, G, Hines, CJ, Blair, A, Lubin, J, et al.. Use of acetochlor and cancer incidence in the agricultural health study. Int J Canc 2015;137:1167–75. https://doi.org/10.1002/ijc.29416.Search in Google Scholar

31. Frost, G, Brown, T, Harding, A-H. Mortality and cancer incidence among British agricultural pesticide users. Occup Med 2011;61:303–10. https://doi.org/10.1093/occmed/kqr067.Search in Google Scholar

32. Viel, JF, Challier, B. Bladder cancer among French farmers: does exposure to pesticides in vineyards play a part? Occup Environ Med 1995;52:587–92. https://doi.org/10.1136/oem.52.9.587.Search in Google Scholar

33. Vazirinejad, R, Khalili, P, Rezaeian, M, Jamalizadeh, A, Puorkarami, AH. The impact of exposure to pesticides on the risk of gastrointestinal cancer among pistachio farmers; a case-control study. J Occupat Health Epidemol 2015;4:205–12. https://doi.org/10.18869/acadpub.johe.4.4.205.Search in Google Scholar

34. Karunanayake, CP, Spinelli, JJ, McLaughlin, JR, Dosman, JA, Pahwa, P, McDuffie, HH. Hodgkin lymphoma and pesticides exposure in men: a Canadian case-control study. J Agromed 2012;17:30–9. https://doi.org/10.1080/1059924x.2012.632726.Search in Google Scholar

35. Rusiecki, JA, De Roos, A, Lee, WJ, Dosemeci, M, LUbin, JH, Hoppin, JA, et al.. Cancer incidence among pesticide applicators exposed to atrazine in the Agricultural Health Study. J Natl Cancer Inst 2004;96:1375–82. https://doi.org/10.1093/jnci/djh264.Search in Google Scholar

36. Swaen, GMH, Vliet, C, Slangen, JJM, Sturmans, F. Cancer mortality among licensed herbicide applicators. Scand J Work Environ Health 1992;18:201–4. https://doi.org/10.5271/sjweh.1587.Search in Google Scholar

37. Dich, J, Wiklund, K. Prostate cancer in pesticide applicators in Swedish agriculture. Prostate 1998;34:100–12. .10.1002/(SICI)1097-0045(19980201)34:2<100::AID-PROS4>3.0.CO;2-OSearch in Google Scholar

38. Mahajan, R, Blair, A, Lynch, CF, Schroeder, P, Hoppin, JA, Sandler, DP, et al.. Fonofos exposure and cancer incidence in the agricultural health study. Environ Health Perspect 2006;114:1838–42. https://doi.org/10.1289/ehp.9301.Search in Google Scholar

39. Lee, WJ, Blair, A, Hoppin, JA, Lubin, JH, Rusiecki, JA, Sandler, DP, et al.. Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. J Natl Cancer Inst 2004;96:1781–9. https://doi.org/10.1093/jnci/djh324.Search in Google Scholar

40. Lee, WJ, Hoppin, JA, Blair, A, Lubin, JH, Dosemeci, M, Sandler, DP, et al.. Cancer incidence among pesticide applicators exposed to alachlor in the Agricultural Health Study. Am J Epidemiol 2004;159:373–80. https://doi.org/10.1093/aje/kwh040.Search in Google Scholar

41. Mahajan, R, Blair, A, Coble, J, Lynch, CF, Hoppin, JA, Sandler, DP, et al.. Carbaryl exposure and incident cancer in the agricultural health study. Int J Canc 2007;121:1799–805. https://doi.org/10.1002/ijc.22836.Search in Google Scholar

42. Weichenthal, S, Moase, C, Chan, PA. Review of pesticide exposure and cancer incidence in the agricultural health study cohort. Environ Health Perspect 2010;118:1117–25. https://doi.org/10.1289/ehp.0901731.Search in Google Scholar

43. Pesticide Action Network (PAN). Cancer. Available from: .Search in Google Scholar

44. Dosemeci, M, Alavanja, MC, Rowland, AS, Mage, D, Zahm, SH, Rothman, N, et al.. A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg 2002;46:245–60. https://doi.org/10.1093/annhyg/mef011.Search in Google Scholar

45. Weichenthal, S, Moase, C, Chan, P. A review of pesticide exposure and cancer incidence in the Agricultural Health Study cohort. Environ Health Perspect 2010;118:1117–25. https://doi.org/10.1289/ehp.0901731.Search in Google Scholar

Received: 2020-09-09
Accepted: 2020-11-03
Published Online: 2020-12-10
Published in Print: 2021-12-20

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