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Licensed Unlicensed Requires Authentication Published by De Gruyter April 1, 2021

Adverse effects of PM2.5 on cardiovascular diseases

  • Liwei Yang , Yuezhu Zhang , Wen Qi , Tianyang Zhao , Lele Zhang , Liting Zhou EMAIL logo and Lin Ye EMAIL logo


As an air pollutant, fine particulate matter with a diameter  ≤ 2.5 μm (PM2.5) can enter the body through the respiratory tract and cause adverse cardiovascular effects. Here, the effects of PM2.5 on atherosclerosis, hypertension, arrhythmia, myocardial infarction are summarized from the perspective researches of human epidemiology, animal, cell and molecule. The results of this review should be proved useful as a scientific basis for the prevention and treatment of cardiovascular disease caused by PM2.5.

Corresponding authors: Liting Zhou and Lin Ye, Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, China, E-mail: (L. Zhou), (L. Ye)
Liwei Yang and Yuezhu Zhang contributed to the work equally and should be regarded as co-first authors.

Award Identifier / Grant number: 81803190


Not applicable.

  1. Research funding: This work was sponsored by the National Natural Science Foundation of China (81803190), and the Fundamental Research Funds for the Central Universities.

  2. Author contributions: Dr Ye and Dr Zhou determined the title of the review and modified it. Mr Yang, Miss Zhang1, Miss Qi, Miss Zhao and Miss Zhang2 searched the relevant literature. Mr Yang and Miss Zhang1 wrote this review. All authors approved the final manuscript.

  3. Competing interests: All the authors have no conflicts of interest to declare.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


1. Lu, F, Xu, D, Cheng, Y, Dong, S, Guo, C, Jiang, X, et al.. Systematic review and meta-analysis of the adverse health effects of ambient PM2.5 and PM10 pollution in the Chinese population. Environ Res 2015;136:196–204. in Google Scholar PubMed

2. Zhang, T, Zheng, X, Wang, X, Zhao, H, Wang, T, Zhang, H, et al.. Maternal exposure to PM2.5 during pregnancy induces impaired development of cerebral cortex in mice offspring. Int J Mol Sci 2018;19:257. in Google Scholar PubMed PubMed Central

3. Zheng, X, Wang, X, Wang, T, Zhang, H, Wu, H, Zhang, C, et al.. Gestational exposure to particulate matter 2.5 (PM2.5) leads to spatial memory dysfunction and neurodevelopmental impairment in hippocampus of mice offspring. Front Neurosci 2018;12:1000. in Google Scholar PubMed PubMed Central

4. Chenxu, G, Minxuan, X, Yuting, Q, Tingting, G, Jinxiao, L, Mingxing, W, et al.. iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress. Redox Biol 2018;19:147–57. in Google Scholar PubMed PubMed Central

5. Zhang, Y, Li, Q, Fang, M, Ma, Y, Liu, N, Yan, X, et al.. The kidney injury induced by short-term PM2.5 exposure and the prophylactic treatment of essential oils in BALB/c mice. Oxid Med Cell Longev 2018;2018:9098627. in Google Scholar PubMed PubMed Central

6. Wang, X, Hui, Y, Zhao, L, Hao, Y, Guo, H, Ren, F. Oral administration of Lactobacillus paracasei L9 attenuates PM2.5-induced enhancement of airway hyperresponsiveness and allergic airway response in murine model of asthma. PLoS One 2017;12:e0171721. in Google Scholar PubMed PubMed Central

7. Li, R, Zhou, R, Zhang, J. Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases. Oncol Lett 2018;15:7506–14. in Google Scholar PubMed PubMed Central

8. Ding, A, Yang, Y, Zhao, Z, Huls, A, Vierkotter, A, Yuan, Z, et al.. Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep 2017;7:15329. in Google Scholar PubMed PubMed Central

9. Parker, JD, Talih, M, Malec, DJ, Beresovsky, V, Carroll, M, Gonzalez, JF, et al.. National Center for Health Statistics data presentation standards for proportions. Vital Health Stat 2017;2:1–22.Search in Google Scholar

10. Zhu, J, Zhao, Y, Gao, Y, Li, C, Zhou, L, Qi, W, et al.. Effects of different components of PM2.5 on the expression levels of NF-kappaB family gene mRNA and inflammatory molecules in human macrophage. Int J Environ Res Publ Health 2019;16:1408. in Google Scholar PubMed PubMed Central

11. Yue, W, Tong, L, Liu, X, Weng, X, Chen, X, Wang, D, et al.. Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy. Redox Biol 2019;22:101161. in Google Scholar PubMed PubMed Central

12. Chen, Y, Hu, K, Bu, H, Si, Z, Sun, H, Chen, L, et al.. Probucol protects circulating endothelial progenitor cells from ambient PM2.5 damage via inhibition of reactive oxygen species and inflammatory cytokine production in vivo. Exp Ther Med 2018;16:4322–8.10.3892/etm.2018.6791Search in Google Scholar PubMed PubMed Central

13. Dai, J, Chen, W, Lin, Y, Wang, S, Guo, X, Zhang, QQ. Exposure to concentrated ambient fine particulate matter induces vascular endothelial dysfunction via miR-21. Int J Biol Sci 2017;13:868–77. in Google Scholar PubMed PubMed Central

14. Pope, CA3rd, Bhatnagar, A, McCracken, JP, Abplanalp, W, Conklin, DJ, O’Toole, T. Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ Res 2016;119:1204–14. in Google Scholar PubMed PubMed Central

15. Mai, AS, Dos Santos, AB, Beber, LCC, Basso, RDB, Sulzbacher, LM, Goettems-Fiorin, PB, et al.. Exercise training under exposure to low levels of fine particulate matter: effects on heart oxidative stress and extra-to-intracellular HSP70 ratio. Oxid Med Cell Longev 2017;2017:9067875. in Google Scholar PubMed PubMed Central

16. Rao, X, Zhong, J, Brook, RD, Rajagopalan, S. Effect of particulate matter air pollution on cardiovascular oxidative stress pathways. Antioxid Redox Signal 2018;28:797–818. in Google Scholar PubMed PubMed Central

17. Carll, AP, Crespo, SM, Filho, MS, Zati, DH, Coull, BA, Diaz, EA, et al.. Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. Part Fibre Toxicol 2017;14:16. in Google Scholar PubMed PubMed Central

18. Oh, SM, Kim, HR, Park, YJ, Lee, SY, Chung, KH. Organic extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells). Mutat Res 2011;723:142–51. in Google Scholar PubMed

19. Tao, J, Zhang, L, Cao, J, Zhang, R. A review of current knowledge concerning PM2.5 chemical composition, aerosol optical properties and their relationships across China. Atmos Chem Phys 2017;77:1030–4.10.5194/acp-2017-271Search in Google Scholar

20. Feng, S, Gao, D, Liao, F, Zhou, F, Wang, X. The health effects of ambient PM2.5 and potential mechanisms. Ecotoxicol Environ Saf 2016;128:67–74. in Google Scholar PubMed

21. Zhao, J, Gao, Z, Tian, Z, Xie, Y, Xin, F, Jiang, R, et al.. The biological effects of individual-level PM(2.5) exposure on systemic immunity and inflammatory response in traffic policemen. Occup Environ Med 2013;70:426–31. in Google Scholar PubMed

22. Zhang, Z, Chang, LY, Lau, AKH, Chan, TC, Chieh Chuang, Y, Chan, J, et al.. Satellite-based estimates of long-term exposure to fine particulate matter are associated with C-reactive protein in 30 034 Taiwanese adults. Int J Epidemiol 2017;46:1126–36. in Google Scholar PubMed PubMed Central

23. Zwaka, TP, Hombach, V, Torzewski, J. C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation 2001;103:1194–7. in Google Scholar PubMed

24. Swirski, FK, Pittet, MJ, Kircher, MF, Aikawa, E, Jaffer, FA, Libby, P, et al.. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A 2006;103:10340–5. in Google Scholar PubMed PubMed Central

25. Zhu, X, Zhao, P, Lu, Y, Huo, L, Bai, M, Yu, F, et al.. Potential injurious effects of the fine particulate PM2.5 on the progression of atherosclerosis in apoE-deficient mice by activating platelets and leukocytes. Arch Med Sci 2019;15:250–61. in Google Scholar PubMed PubMed Central

26. Ziegler, L, Lundqvist, J, Dreij, K, Wallen, H, de Faire, U, Paulsson-Berne, G, et al.. Expression of Interleukin 6 signaling receptors in carotid atherosclerosis. Vasc Med 2020;26:3–10. in Google Scholar PubMed PubMed Central

27. Al-Shorman, A, Al-Domi, H, Faqih, A. Markers of subclinical atherosclerosis in schoolchildren with obesity and metabolic syndrome. Swiss Med Wkly 2017;147:w14446. in Google Scholar PubMed

28. Wang, J, Li, R, Peng, Z, Zhou, W, Hu, B, Rao, X, et al.. GTS-21 reduces inflammation in acute lung injury by regulating M1 polarization and function of alveolar macrophages. Shock 2019;51:389–400. in Google Scholar

29. Rojas, J, Salazar, J, Martinez, MS, Palmar, J, Bautista, J, Chavez-Castillo, M, et al.. Macrophage heterogeneity and plasticity: impact of macrophage biomarkers on atherosclerosis. Scientifica (Cairo) 2015;2015:851252. in Google Scholar PubMed PubMed Central

30. He, M, Ichinose, T, Yoshida, S, Nishikawa, M, Mori, I, Yanagisawa, R, et al.. Urban particulate matter in Beijing, China, enhances allergen-induced murine lung eosinophilia. Inhal Toxicol 2010;22:709–18. in Google Scholar PubMed

31. Yoshizaki, K, Brito, JM, Toledo, AC, Nakagawa, NK, Piccin, VS, Junqueira, MS, et al.. Subchronic effects of nasally instilled diesel exhaust particulates on the nasal and airway epithelia in mice. Inhal Toxicol 2010;22:610–7. in Google Scholar PubMed

32. Zhao, Q, Chen, H, Yang, T, Rui, W, Liu, F, Zhang, F, et al.. Direct effects of airborne PM2.5 exposure on macrophage polarizations. Biochim Biophys Acta 2016;1860:2835–43. in Google Scholar PubMed

33. Friedrich, FW, Reischmann, S, Schwalm, A, Unger, A, Ramanujam, D, Munch, J, et al.. FHL2 expression and variants in hypertrophic cardiomyopathy. Basic Res Cardiol 2014;109:451. in Google Scholar PubMed PubMed Central

34. Xia, WR, Fu, W, Wang, Q, Zhu, X, Xing, WW, Wang, M, et al.. Autophagy induced FHL2 upregulation promotes IL-6 production by activating the NF-kappaB pathway in mouse aortic endothelial cells after exposure to PM2.5. Int J Mol Sci 2017;18:1484. in Google Scholar PubMed PubMed Central

35. Friesen, RW, Mancini, JA. Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target. J Med Chem 2008;51:4059–67. in Google Scholar PubMed

36. Alberini, CM. Transcription factors in long-term memory and synaptic plasticity. Physiol Rev 2009;89:121–45. in Google Scholar PubMed PubMed Central

37. Yin, J, Xia, W, Li, Y, Guo, C, Zhang, Y, Huang, S, et al.. COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells. Am J Transl Res 2017;9:3967–76.Search in Google Scholar

38. Libby, P, Bornfeldt, KE, Tall, AR. Atherosclerosis: successes, surprises, and future challenges. Circ Res 2016;118:531–4. in Google Scholar PubMed PubMed Central

39. Paone, S, Baxter, AA, Hulett, MD, Poon, IKH. Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis. Cell Mol Life Sci 2019;76:1093–106. in Google Scholar PubMed

40. Abdelrahim, M, Konduri, S, Basha, R, Philip, PA, Baker, CH. Angiogenesis: an update and potential drug approaches (review). Int J Oncol 2010;36:5–18.10.3892/ijo_00000470Search in Google Scholar

41. Chen, S, Wu, X, Hu, J, Dai, G, Rong, A, Guo, G. PM2.5 exposure decreases viability, migration and angiogenesis in human umbilical vein endothelial cells and human microvascular endothelial cells. Mol Med Rep 2017;16:2425–30. in Google Scholar PubMed PubMed Central

42. Zhu, F, Cheng, H, Lei, R, Shen, C, Liu, J, Hou, L, et al.. Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF/VEGFR2/MEK1/2/ERK1/2/mTOR pathway in human umbilical vein endothelial cells. Environ Toxicol Pharmacol 2019;69:112–9. in Google Scholar PubMed

43. Xu, X, Qimuge, A, Wang, H, Xing, C, Gu, Y, Liu, S, et al.. IRE1alpha/XBP1s branch of UPR links HIF1alpha activation to mediate ANGII-dependent endothelial dysfunction under particulate matter (PM) 2.5 exposure. Sci Rep 2017;7:13507. in Google Scholar PubMed PubMed Central

44. Te Riet, L, van Esch, JH, Roks, AJ, van den Meiracker, AH, Danser, AH. Hypertension: renin-angiotensin-aldosterone system alterations. Circ Res 2015;116:960–75. in Google Scholar PubMed

45. Montiel-Davalos, A, Alfaro-Moreno, E, Lopez-Marure, R. PM2.5 and PM10 induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells. Inhal Toxicol 2007;19:91–8. in Google Scholar PubMed

46. Jia, G, Aroor, AR, Jia, C, Sowers, JR. Endothelial cell senescence in aging-related vascular dysfunction. Biochim Biophys Acta (BBA) – Mol Basis Dis 2019;1865:1802–9. in Google Scholar PubMed

47. Dai, J, Sun, C, Yao, Z, Chen, W, Yu, L, Long, M. Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrier function via the IL-6/HIF-1alpha signaling pathway. FEBS Open Bio 2016;6:720–8. in Google Scholar PubMed PubMed Central

48. Wirawan, E, Vanden Berghe, T, Lippens, S, Agostinis, P, Vandenabeele, P. Autophagy: for better or for worse. Cell Res 2012;22:43–61. in Google Scholar PubMed PubMed Central

49. Wang, Y, Tang, M. PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells. Sci Total Environ 2019;710.10.1016/j.scitotenv.2019.136397Search in Google Scholar PubMed

50. Miao, X, Li, W, Niu, B, Li, J, Sun, J, Qin, M, et al.. Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm). J Appl Toxicol 2019;39:1424–32. in Google Scholar PubMed

51. Bick, RL. Disseminated intravascular coagulation and related syndromes: a clinical review. Semin Thromb Hemost 1988;14:299–338. in Google Scholar PubMed

52. Asakura, H, Takahashi, H, Uchiyama, T, Eguchi, Y, Okamoto, K, Kawasugi, K, et al.. Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. Thromb J 2016;14:42. in Google Scholar PubMed PubMed Central

53. Bick, RL. Disseminated intravascular coagulation: a review of etiology, pathophysiology, diagnosis, and management: guidelines for care. Clin Appl Thromb Hemost 2002;8:1–31. in Google Scholar PubMed

54. Su, TC, Hwang, JJ, Yang, YR, Chan, CC. Association between long-term exposure to traffic-related air pollution and inflammatory and thrombotic markers in middle-aged adults. Epidemiology 2017;28:S74–81. in Google Scholar

55. Liang, S, Zhao, T, Hu, H, Shi, Y, Xu, Q, Miller, MR, et al.. Repeat dose exposure of PM2.5 triggers the disseminated intravascular coagulation (DIC) in SD rats. Sci Total Environ 2019;663:245–53. in Google Scholar PubMed PubMed Central

56. Robertson, S, Miller, MR. Ambient air pollution and thrombosis. Part Fibre Toxicol 2018;15:1. in Google Scholar PubMed PubMed Central

57. Yitshak Sade, M, Kloog, I, Liberty, IF, Schwartz, J, Novack, V. The association between air pollution exposure and glucose and lipids levels. J Clin Endocrinol Metab 2016;101:2460–7. in Google Scholar PubMed

58. Chen, T, Jia, G, Wei, Y, Li, J. Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice. Toxicol Lett 2013;223:146–53. in Google Scholar PubMed

59. Shea, S, Stein, JH, Jorgensen, NW, McClelland, RL, Tascau, L, Shrager, S, et al.. Cholesterol mass efflux capacity, incident cardiovascular disease, and progression of carotid plaque. Arterioscler Thromb Vasc Biol 2019;39:89–96. in Google Scholar PubMed PubMed Central

60. Ribeiro, JP, Kalb, AC, Campos, PP, Cruz, ARH, Martinez, PE, Gioda, A, et al.. Toxicological effects of particulate matter (PM2.5) on rats: bioaccumulation, antioxidant alterations, lipid damage, and ABC transporter activity. Chemosphere 2016;163:569–77. in Google Scholar PubMed

61. Geng, J, Liu, H, Ge, P, Hu, T, Zhang, Y, Zhang, X, et al.. PM2.5 promotes plaque vulnerability at different stages of atherosclerosis and the formation of foam cells via TLR4/MyD88/NFkappaB pathway. Ecotoxicol Environ Saf 2019;176:76–84. in Google Scholar PubMed

62. Xie, X, Wang, Y, Yang, Y, Xu, J, Zhang, Y, Tang, W, et al.. Long-term effects of ambient particulate matter (with an aerodynamic diameter ≤2.5 μm) on hypertension and blood pressure and attributable risk among reproductive-age adults in China. J Am Heart Assoc 2018;7. in Google Scholar PubMed PubMed Central

63. Huang, K, Yang, X, Liang, F, Liu, F, Li, J, Xiao, Q, et al.. Long-term exposure to fine particulate matter and hypertension incidence in China. Hypertension 2019;73:1195–201. in Google Scholar PubMed PubMed Central

64. Wu, Y, Ye, Z, Fang, Y. Spatial analysis of the effects of PM2.5 on hypertension among the middle-aged and elderly people in China. Int J Environ Health Res 2019:1–12. in Google Scholar

65. Chang, AY, Skirbekk, VF, Tyrovolas, S, Kassebaum, NJ, Dieleman, JL. Measuring population ageing: an analysis of the Global Burden of Disease Study 2017. Lancet Public Health 2019;4:e159–67. in Google Scholar

66. Lin, H, Guo, Y, Zheng, Y, Di, Q, Liu, T, Xiao, J, et al.. Long-term effects of ambient PM2.5 on hypertension and blood pressure and attributable risk among older Chinese adults. Hypertension 2017;69:806–12. in Google Scholar

67. Akbarzadeh, MA, Khaheshi, I, Sharifi, A, Yousefi, N, Naderian, M, Namazi, MH, et al.. The association between exposure to air pollutants including PM10, PM2.5, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide concentration and the relative risk of developing STEMI: a case-crossover design. Environ Res 2018;161:299–303. in Google Scholar PubMed

68. Baumgartner, J, Schauer, JJ, Ezzati, M, Lu, L, Cheng, C, Patz, JA, et al.. Indoor air pollution and blood pressure in adult women living in rural China. Environ Health Perspect 2011;119:1390–5. in Google Scholar PubMed PubMed Central

69. Belcik, MK, Trusz-Zdybek, A, Zaczynska, E, Czarny, A, Piekarska, K. Genotoxic and cytotoxic properties of PM2.5 collected over the year in Wroclaw (Poland). Sci Total Environ 2018;637–638:480–97.10.1016/j.scitotenv.2018.04.166Search in Google Scholar PubMed

70. Zhang, M, Mueller, NT, Wang, H, Hong, X, Appel, LJ, Wang, X. Maternal exposure to ambient particulate matter ≤2.5 μm during pregnancy and the risk for high blood pressure in childhood. Hypertension 2018;72:194–201. in Google Scholar PubMed PubMed Central

71. Abdo, M, Ward, I, O’Dell, K, Ford, B, Pierce, JR, Fischer, EV, et al.. Impact of wildfire smoke on adverse pregnancy outcomes in Colorado, 2007–2015. Int J Environ Res Publ Health 2019;16:3720. in Google Scholar PubMed PubMed Central

72. Zwertbroek, EF, Franssen, MTM, Broekhuijsen, K, Langenveld, J, Bremer, H, Ganzevoort, W, et al.. Neonatal developmental and behavioral outcomes of immediate delivery versus expectant monitoring in mild hypertensive disorders of pregnancy: 2-year outcomes of the HYPITAT-II trial. Am J Obstet Gynecol 2019;221:154.e1–11. in Google Scholar PubMed

73. Herrera, M, Coffman, TM. The kidney and hypertension: novel insights from transgenic models. Curr Opin Nephrol Hypertens 2012;21:171–8. in Google Scholar PubMed

74. Lifton, RP, Hunt, SC, Williams, RR, Pouyssegur, J, Lalouel, JM. Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension. Hypertension 1991;17:8–14. in Google Scholar PubMed

75. Ye, Z, Lu, X, Deng, Y, Wang, X, Zheng, S, Ren, H, et al.. In utero exposure to fine particulate matter causes hypertension due to impaired renal dopamine D1 receptor in offspring. Cell Physiol Biochem 2018;46:148–59. in Google Scholar PubMed PubMed Central

76. Zheng, Q, Liu, H, Zhang, J, Chen, D. The effect of ambient particle matters on hospital admissions for cardiac arrhythmia: a multi-city case-crossover study in China. Environ Health 2018;17:60. in Google Scholar PubMed PubMed Central

77. Yang, M, Zhou, R, Qiu, X, Feng, X, Sun, J, Wang, Q, et al.. Artificial intelligence-assisted analysis on the association between exposure to ambient fine particulate matter and incidence of arrhythmias in outpatients of Shanghai community hospitals. Environ Int 2020;139:105745. in Google Scholar PubMed

78. He, F, Shaffer, ML, Rodriguez-Colon, S, Yanosky, JD, Bixler, E, Cascio, WE, et al.. Acute effects of fine particulate air pollution on cardiac arrhythmia: the APACR study. Environ Health Perspect 2011;119:927–32. in Google Scholar PubMed PubMed Central

79. Tsai, TY, Lo, LW, Liu, SH, Cheng, WH, Chou, YH, Lin, WL, et al.. Ambient fine particulate matter (PM2.5) exposure is associated with idiopathic ventricular premature complexes burden: a cohort study with consecutive Holter recordings. J Cardiovasc Electrophysiol 2019;30:487–92. in Google Scholar PubMed

80. Krijthe, BP, Kunst, A, Benjamin, EJ, Lip, GY, Franco, OH, Hofman, A, et al.. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur Heart J 2013;34:2746–51. in Google Scholar PubMed PubMed Central

81. Miyasaka, Y, Barnes, ME, Gersh, BJ, Cha, SS, Bailey, KR, Abhayaratna, WP, et al.. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation 2006;114:119–25. in Google Scholar

82. Link, MS, Luttmann-Gibson, H, Schwartz, J, Mittleman, MA, Wessler, B, Gold, DR, et al.. Acute exposure to air pollution triggers atrial fibrillation. J Am Coll Cardiol 2013;62:816–25. in Google Scholar PubMed PubMed Central

83. Cai, C, Huang, J, Lin, Y, Miao, W, Chen, P, Chen, X, et al.. Particulate matter 2.5 induced arrhythmogenesis mediated by TRPC3 in human induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol 2019;93:1009–20. in Google Scholar PubMed

84. Cramer, J, Jorgensen, JT, Hoffmann, B, Loft, S, Brauner, EV, Prescott, E, et al.. Long-term exposure to air pollution and incidence of myocardial infarction: a Danish nurse cohort study. Environ Health Perspect 2020;128:57003. in Google Scholar

85. Madrigano, J, Kloog, I, Goldberg, R, Coull, BA, Mittleman, MA, Schwartz, J. Long-term exposure to PM2.5 and incidence of acute myocardial infarction. Environ Health Perspect 2013;121:192–6. in Google Scholar PubMed PubMed Central

86. Biondi-Zoccai, G, Frati, G, Gaspardone, A, Mariano, E, Di Giosa, AD, Bolignano, A, et al.. Impact of environmental pollution and weather changes on the incidence of ST-elevation myocardial infarction. Eur J Prev Cardiol 2020:2047487320928450.10.1177/2047487320928450Search in Google Scholar PubMed

87. Gardner, B, Ling, F, Hopke, PK, Frampton, MW, Utell, MJ, Zareba, W, et al.. Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study. Part Fibre Toxicol 2014;11:1. in Google Scholar PubMed PubMed Central

88. Wang, G, Zhen, L, Lu, P, Jiang, R, Song, W. Effects of ozone and fine particulate matter (PM2.5) on rat cardiac autonomic nervous system and systemic inflammation. Wei Sheng Yan Jiu 2013;42:554–60.10.1016/j.toxlet.2012.11.009Search in Google Scholar

89. Chuang, KJ, Chan, CC, Su, TC, Lee, CT, Tang, CS. The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med 2007;176:370–6. in Google Scholar

90. Cowell, WJ, Brunst, KJ, Malin, AJ, Coull, BA, Gennings, C, Kloog, I, et al.. Prenatal exposure to PM2.5 and cardiac vagal tone during infancy: findings from a multiethnic birth cohort. Environ Health Perspect 2019;127:107007. in Google Scholar PubMed PubMed Central

91. Tang, V, Fu, S, Rayner, BS, Hawkins, CL. 8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response. Redox Biol 2019;26:101274. in Google Scholar PubMed PubMed Central

92. Zhang, K, Kaufman, RJ. Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 2004;279:25935–8. in Google Scholar

93. Zhang, Y, Li, S, Li, J, Han, L, He, Q, Wang, R, et al.. Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos. Chemosphere 2018;197:611–21. in Google Scholar PubMed

94. Li, J, Zhao, F, Wang, Y, Chen, J, Tao, J, Tian, G, et al.. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome 2017;5:14. in Google Scholar PubMed PubMed Central

Received: 2020-11-24
Accepted: 2021-03-14
Published Online: 2021-04-01
Published in Print: 2022-03-28

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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