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Exposure to magnetic fields and childhood leukemia: a systematic review and meta-analysis of case-control and cohort studies

  • Christian Brabant EMAIL logo , Anton Geerinck , Charlotte Beaudart , Ezio Tirelli , Christophe Geuzaine and Olivier Bruyère


The association between childhood leukemia and extremely low frequency magnetic fields (ELF-MF) generated by power lines and various electric appliances has been studied extensively during the past 40 years. However, the conditions under which ELF-MF represent a risk factor for leukemia are still unclear. Therefore, we have performed a systematic review and meta-analysis to clarify the relation between ELF-MF from several sources and childhood leukemia. We have systematically searched Medline, Scopus, Cochrane Database of Systematic Review and DARE to identify each article that has examined the relationship between ELF-MF and childhood leukemia. We have performed a global meta-analysis that takes into account the different measures used to assess magnetic field exposure: magnetic flux density measurements (<0.2 µT vs. >0.2 µT), distances between the child’s home and power lines (>200 m vs. <200 m) and wire codings (low current configuration vs. high current configuration). Moreover, meta-analyses either based on magnetic flux densities, on proximity to power lines or on wire codings have been performed. The association between electric appliances and childhood leukemia has also been examined. Of the 863 references identified, 38 studies have been included in our systematic review. Our global meta-analysis indicated an association between childhood leukemia and ELF-MF (21 studies, pooled OR=1.26; 95% CI 1.06–1.49), an association mainly explained by the studies conducted before 2000 (earlier studies: pooled OR=1.51; 95% CI 1.26–1.80 vs. later studies: pooled OR=1.04; 95% CI 0.84–1.29). Our meta-analyses based only on magnetic field measurements indicated that the magnetic flux density threshold associated with childhood leukemia is higher than 0.4 µT (12 studies, >0.4 µT: pooled OR=1.37; 95% CI 1.05–1.80; acute lymphoblastic leukemia alone: seven studies, >0.4 µT: pooled OR=1.88; 95% CI 1.31–2.70). Lower magnetic fields were not associated with leukemia (12 studies, 0.1–0.2 µT: pooled OR=1.04; 95% CI 0.88–1.24; 0.2–0.4 µT: pooled OR=1.07; 95% CI 0.87–1.30). Our meta-analyses based only on distances (five studies) showed that the pooled ORs for living within 50 m and 200 m of power lines were 1.11 (95% CI 0.81–1.52) and 0.98 (95% CI 0.85–1.12), respectively. The pooled OR for living within 50 m of power lines and acute lymphoblastic leukemia analyzed separately was 1.44 (95% CI 0.72–2.88). Our meta-analyses based only on wire codings (five studies) indicated that the pooled OR for the very high current configuration (VHCC) was 1.23 (95% CI 0.72–2.10). Finally, the risk of childhood leukemia was increased after exposure to electric blankets (four studies, pooled OR=2.75; 95% CI 1.71–4.42) and, to a lesser extent, electric clocks (four studies, pooled OR=1.27; 95% CI 1.01–1.60). Our results suggest that ELF-MF higher than 0.4 µT can increase the risk of developing leukemia in children, probably acute lymphoblastic leukemia. Prolonged exposure to electric appliances that generate magnetic fields higher than 0.4 µT like electric blankets is associated with a greater risk of childhood leukemia.

Corresponding author: Christian Brabant, WHO Collaborating Centre for Public Health Aspects of Musculo-Skeletal Health and Ageing, Division of Public Health, Epidemiology and Health Economics, University of Liège, Avenue Hippocrate, 13/B-23, B-4000 Liège, Belgium; and Department of Psychology, Cognition and Behavior, University of Liège, Place des Orateurs, 2/B-32, Liège, Belgium, Phone: +32 43 66 25 81, Fax: +32 43 66 28 12, E-mail:

Funding source: University of Liège

  1. Research funding: The present work was supported by a grant obtained by the University of Liège from the Belgian BioElectroMagnetics Group (BBEMG). The funding organization played no role in the study design, in the collection, analysis and interpretation of data, in the writing of the report or in the decision to submit the report for publication.

  2. Author contributions: Each author has consented to their names upon the article and has made a significant contribution to this article. Professor Olivier Bruyère, Dr Christian Brabant and Dr Charlotte Beaudart have designed the study. Dr Christian Brabant and Anton Geerinck have collected the data. Dr Christian Brabant and Dr Charlotte Beaudart have performed the statistical analysis. All authors have interpreted the data, wrote and revised the manuscript critically for important intellectual content. All authors have approved the final version to be published. All authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  3. Competing interests: This work was supported by a grant obtained by the University of Liège from the Belgian BioElectroMagnetics Group (BBEMG).

  4. Ethical approval: Not applicable. No ethical approval was required as this was a systematic review and did not use primary data.

  5. Informed consent: Not applicable, as this work was a systematic review and did not use primary data.

  6. Data availability: Data are available from Dr Christian Brabant () with a reasonable request.


1. Jin, MW, Xu, SM, An, Q, Wang, P. A review of risk factors for childhood leukemia. Eur Rev Med Pharmacol Sci 2016;20:3760–4.Search in Google Scholar

2. Wertheimer, N, Leeper, E. Electrical wiring configurations and childhood cancer. Am J Epidemiol 1979;109:273–84. in Google Scholar PubMed

3. Ahlbom, A, Day, N, Feychting, M, Roman, E, Skinner, J, Dockerty, J, et al.. A pooled analysis of magnetic fields and childhood leukaemia. Br J Cancer 2000;83:692–8. in Google Scholar PubMed PubMed Central

4. Kabuto, M, Nitta, H, Yamamoto, S, Yamaguchi, N, Akiba, S, Honda, Y, et al.. Childhood leukemia and magnetic fields in Japan: a case-control study of childhood leukemia and residential power-frequency magnetic fields in Japan. Int J Cancer 2006;119:643–50. in Google Scholar PubMed

5. Linet, MS, Hatch, EE, Kleinerman, RA, Robison, LL, Kaune, WT, Friedman, DR, et al.. Residential exposure to magnetic fields and acute lymphoblastic leukemia in children. N Engl J Med 1997;337:1–7.10.1056/NEJM199707033370101Search in Google Scholar PubMed

6. McBride, ML, Gallagher, RP, Thériault, G, Armstrong, BG, Tamaro, S, Spinelli, JJ, et al.. Powerfrequency electric and magnetic fields and risk of childhood leukemia in Canada. Am J Epidemiol 1999;149:831–42. in Google Scholar PubMed

7. Karimi, A, Ghadiri Moghaddam, F, Valipour, M. Insights in the biology of extremely lowfrequency magnetic fields exposure on human health. Mol Biol Rep 2020;47:5621–33. in Google Scholar PubMed

8. Hatch, EE, Linet, MS, Kleinerman, RA, Tarone, RE, Severson, RK, Hartsock, CT, et al.. Association between childhood acute lymphoblastic leukemia and use of electrical appliances during pregnancy and childhood. Epidemiology 1998;9:234–45.10.1097/00001648-199805000-00006Search in Google Scholar

9. Savitz, DA, John, EM, Kleckner, RC. Magnetic field exposure from electric appliances and childhood cancer. Am J Epidemiol 1990;131:763–73. in Google Scholar PubMed

10. Bunch, KJ, Keegan, TJ, Swanson, J, Vincent, TJ, Murphy, MF. Residential distance at birth from overhead high-voltage powerlines: childhood cancer risk in Britain 1962-2008. Br J Cancer 2014;110:1402–8. in Google Scholar PubMed PubMed Central

11. Kroll, ME, Swanson, J, Vincent, TJ, Draper, GJ. Childhood cancer and magnetic fields from high-voltage power lines in England and Wales: a case-control study. Br J Cancer 2010;103:1122–7. in Google Scholar PubMed PubMed Central

12. Coleman, M, Beral, V. A review of epidemiological studies of the health effects of living near or working with electricity generation and transmission equipment. Int J Epidemiol 1988;17:1–13. in Google Scholar PubMed

13. IARC. Monographs on the evaluation of carcinogenic risks to humans. Non-ionizing radiation: I, static and extremely low-frequency (ELF) electric and magnetic fields. Lyon: IARC; 2002, vol 80.Search in Google Scholar

14. Zhao, L, Liu, X, Wang, C, Yan, K, Lin, X, Li, S, et al.. Magnetic fields exposure and childhood leukemia risk: a meta-analysis based on 11,699 cases and 13,194 controls. Leuk Res 2014;38:269–74. in Google Scholar PubMed

15. Seomun, G, Lee, J, Park, J. Exposure to extremely low-frequency magnetic fields and cancer: a systematic review and meta-analysis. PLoS One 2021;16:e0251628. in Google Scholar PubMed PubMed Central

16. Amoon, AT, Crespi, CM, Ahlbom, A, Bhatnagar, M, Bray, I, Bunch, KJ, et al.. Proximity to overhead power lines and childhood leukaemia: an international pooled analysis. Br J Cancer 2018;119:364–73. in Google Scholar PubMed PubMed Central

17. Amoon, AT, Swanson, J, Magnani, C, Johansen, C, Kheifets, L. Pooled analysis of recent studies of magnetic fields and childhood leukemia. Environ Res 2022;204:111993. in Google Scholar PubMed

18. Greenland, S, Sheppard, AR, Kaune, WT, Poole, C, Kelsh, MA. A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Epidemiology 2000;11:624–34. in Google Scholar PubMed

19. Kheifets, L, Ahlbom, A, Crespi, CM, Draper, G, Hagihara, J, Lowenthal, RM, et al.. Pooled analysis of recent studies on magnetic fields and childhood leukaemia. Br J Cancer 2010;103:1128–35. in Google Scholar PubMed PubMed Central

20. Schüz, J, Svendsen, AL, Linet, MS, McBride, ML, Roman, E, Feychting, M, et al.. Nighttime exposure to electromagnetic fields and childhood leukemia: an extended pooled analysis. Am J Epidemiol 2007;166:263–9. in Google Scholar PubMed

21. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009;62:1006–12. in Google Scholar PubMed

22. Stiller, C. Childhood cancer in Britain: incidence, survival, mortality. Oxford: Oxford University Press; 2007.10.1093/acprof:oso/9780198520702.001.0001Search in Google Scholar

23. Birch, J, Marsden, HB. A classification scheme for childhood cancer. Int J Cancer 1987;40:620–4. in Google Scholar

24. Kramarova, E, Stiller, CA. The international classification of childhood cancer. Int J Cancer 1996;68:759–65.10.1002/(SICI)1097-0215(19961211)68:6<759::AID-IJC12>3.0.CO;2-WSearch in Google Scholar

25. Verkasalo, PK, Pukkala, E, Hongisto, MY, Valjus, JE, Järvinen, PJ, Heikkilä, KV, et al.. Risk of cancer in Finnish children living close to power lines. BMJ 1993;307:895–9. in Google Scholar

26. Jirik, V, Pekarek, L, Janout, V, Tomaskova, H. Association between childhood leukaemia and exposure to power-frequency magnetic fields in Middle Europe. Biomed Environ Sci 2012;25:597–601. in Google Scholar

27. Núñez-Enríquez, JC, Correa-Correa, V, Flores-Lujano, J, Pérez-Saldivar, ML, Jiménez-Hernández, E, Martín-Trejo, JA, et al.. Extremely low-frequency magnetic fields and the risk of childhood B-lineage acute lymphoblastic leukemia in a city with high incidence of leukemia and elevated exposure to ELF magnetic fields. Bioelectromagnetics 2020;41:581–97.10.1002/bem.22295Search in Google Scholar

28. Wells, GA, Shea, B, O’Connell, D, Robertson, J, Peterson, J, Welch, V, et al.. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses; 2014. Available from: in Google Scholar

29. London, SJ, Thomas, DC, Bowman, JD, Sobel, E, Cheng, TC, Peters, JM. Exposure to residential electric and magnetic fields and risk of childhood leukemia. Am J Epidemiol 1991;134:923–37. in Google Scholar

30. Crespi, CM, Swanson, J, Vergara, XP, Kheifets, L. Childhood leukemia risk in the California Power Line Study: magnetic fields versus distance from power lines. Environ Res 2019;171:530–5. in Google Scholar

31. Green, LM, Miller, AB, Agnew, DA, Greenberg, ML, Li, J, Villeneuve, PJ, et al.. Childhood leukemia and personal monitoring of residential exposures to electric and magnetic fields in Ontario, Canada. Cancer Causes Control 1999;10:233–43. in Google Scholar

32. Wünsch-Filho, V, Pelissari, DM, Barbieri, FE, Sant’Anna, L, de Oliveira, CT, de Mata, JF, et al.. Exposure to magnetic fields and childhood acute lymphoblastic leukemia in São Paulo, Brazil. Cancer Epidemiol 2011;35:534–9. in Google Scholar

33. Beaudart, C, Zaaria, M, Pasleau, F, Reginster, JY, Bruyère, O. Health outcomes of sarcopenia: a systematic review and meta-analysis. PLoS One 2017;12:e0169548. in Google Scholar

34. Higgins, JPT, Thomas, J, Chandler, J, Cumpston, M, Li, T, Page, MJ, et al., editors. Cochrane handbook for systematic reviews of interventions, 2nd ed. Chichester (UK): John Wiley & Sons; 2019.10.1002/9781119536604Search in Google Scholar

35. Viechtbauer, W. Conducting meta-analyses in R with the metafor package. J Stat Software 2010;36:1–48. in Google Scholar

36. Savitz, DA, Wachtel, H, Barnes, FA, John, EM, Tvrdik, JG. Case-control study of childhood cancer and exposure to 60-Hz magnetic fields. Am J Epidemiol 1988;128:21–38. in Google Scholar

37. Feychting, M, Ahlbom, A. Magnetic fields and cancer in children residing near Swedish high-voltage power lines. Am J Epidemiol 1993;138:467–81. in Google Scholar

38. Michaelis, J, Schüz, J, Meinert, R, Menger, M, Grigat, JP, Kaatsch, P, et al.. Childhood leukemia and electromagnetic fields: results of a population-based case-control study in Germany. Cancer Causes Control 1997;8:167–74. in Google Scholar

39. Petridou, E, Trichopoulos, D, Kravaritis, A, Pourtsidis, A, Dessypris, N, Skalkidis, Y, et al.. Electrical power lines and childhood leukemia: a study from Greece. Int J Cancer 1997;73:345–8.<345::aid-ijc7>;2-#.10.1002/(SICI)1097-0215(19971104)73:3<345::AID-IJC7>3.0.CO;2-#Search in Google Scholar

40. Tynes, T, Haldorsen, T. Electromagnetic fields and cancer in children residing near Norwegian high-voltage power lines. Am J Epidemiol 1997;145:219–26. in Google Scholar

41. Dockerty, JD, Elwood, JM, Skegg, DC, Herbison, GP. Electromagnetic field exposures and childhood cancers in New Zealand. Cancer Causes Control 1998;9:299–309. in Google Scholar

42. Dockerty, JD, Elwood, JM, Skegg, DC, Herbison, GP. Electromagnetic field exposures and childhood leukaemia in New Zealand. Lancet 1999;354:1967–8. in Google Scholar

43. UK Childhood Cancer Study Investigators. Exposure to power-frequency magnetic fields and the risk of childhood cancer. Lancet 1999;354:1925–31.10.1016/S0140-6736(99)10074-6Search in Google Scholar

44. Bianchi, N, Crosignani, P, Rovelli, A, Tittarelli, A, Carnelli, CA, Rossitto, F, et al.. Overhead electricity power lines and childhood leukemia: a registry-based, case-control study. Tumori 2000;86:195–8. in Google Scholar PubMed

45. Kleinerman, RA, Kaune, WT, Hatch, EE, Wacholder, S, Linet, MS, Robison, LL, et al.. Are children living near high-voltage power lines at increased risk of acute lymphoblastic leukemia? Am J Epidemiol 2000;151:512–5. in Google Scholar PubMed

46. Schüz, J, Grigat, JP, Brinkmann, K, Michaelis, J. Residential magnetic fields as a risk factor for childhood acute leukaemia: results from a German population-based case-control study. Int J Cancer 2001;91:728–35.<::aid-ijc1097>;2-d.10.1002/1097-0215(200002)9999:9999<::AID-IJC1097>3.0.CO;2-DSearch in Google Scholar

47. Feizi, AA, Arabi, MA. Acute childhood leukemias and exposure to magnetic fields generated by high voltage overhead power lines - a risk factor in Iran. Asian Pac J Cancer Prev 2007;8:69–72.Search in Google Scholar

48. Mejia-Arangure, JM, Fajardo-Gutierrez, A, Perez-Saldivar, ML, Gorodezky, C, Martinez-Avalos, A, Romero-Guzman, L, et al.. Magnetic fields and acute leukemia in children with Down syndrome. Epidemiology 2007;18:158–61. in Google Scholar

49. Abdul Rahman, HI, Shah, SA, Alias, H, Ibrahim, HM. A case-control study on the association between environmental factors and the occurrence of acute leukemia among children in Klang Valley, Malaysia. Asian Pac J Cancer Prev 2008;9:649–52.Search in Google Scholar

50. Malagoli, C, Fabbi, S, Teggi, S, Calzari, M, Poli, M, Ballotti, E, et al.. Risk of hematological malignancies associated with magnetic fields exposure from power lines: a case-control study in two municipalities of northern Italy. Environ Health 2010;9:16. in Google Scholar

51. Sohrabi, MR, Tarjoman, T, Abadi, A, Yavari, P. Living near overhead high voltage transmission power lines as a risk factor for childhood acute lymphoblastic leukemia: a case-control study. Asian Pac J Cancer Prev 2010;11:423–7.Search in Google Scholar

52. Sermage-Faure, C, Demoury, C, Rudant, J, Goujon-Bellec, S, Guyot-Goubin, A, Deschamps, F, et al.. Childhood leukaemia close to high-voltage power lines – the Geocap study, 2002-2007. Br J Cancer 2013;108:1899–906. in Google Scholar

53. Pedersen, C, Raaschou-Nielsen, O, Rod, NH, Frei, P, Poulsen, AH, Johansen, C, et al.. Distance from residence to power line and risk of childhood leukemia: a population-based case-control study in Denmark. Cancer Causes Control 2014;25:171–7. in Google Scholar

54. Bunch, KJ, Swanson, J, Vincent, TJ, Murphy, MF. Epidemiological study of power lines and childhood cancer in the UK: further analyses. J Radiol Prot 2016;36:437–55. in Google Scholar

55. Pedersen, C, Johansen, C, Schüz, J, Olsen, JH, Raaschou-Nielsen, O. Residential exposure to extremely low-frequency magnetic fields and risk of childhood leukaemia, CNS tumour and lymphoma in Denmark. Br J Cancer 2015;113:1370–4. in Google Scholar

56. Salvan, A, Ranucci, A, Lagorio, S, Magnani, C, SETIL Research Group. Childhood leukemia and 50 Hz magnetic fields: findings from the Italian SETIL case-control study. Int J Environ Res Publ Health 2015;12:2184–204. in Google Scholar

57. Tabrizi, MM, Hosseini, SA. Role of electromagnetic field exposure in childhood acute lymphoblastic leukemia and no impact of urinary alpha-amylase--a case control study in Tehran, Iran. Asian Pac J Cancer Prev 2015;16:7613–8. in Google Scholar

58. Crespi, CM, Vergara, XP, Hooper, C, Oksuzyan, S, Wu, S, Cockburn, M, et al.. Childhood leukaemia and distance from power lines in California: a population-based case-control study. Br J Cancer 2016;115:122–8. in Google Scholar

59. Kheifets, L, Crespi, CM, Hooper, C, Cockburn, M, Amoon, AT, Vergara, XP. Residential magnetic fields exposure and childhood leukemia: a population-based case-control study in California. Cancer Causes Control 2017;28:1117–23. in Google Scholar

60. Li, CY, Lee, WC, Lin, RS. Risk of leukemia in children living near high-voltage transmission lines. J Occup Environ Med 1998;40:144–7. in Google Scholar

61. The World Bank Group. 2021. Available from: in Google Scholar

62. Swanson, J, Kheifets, L, Vergara, X. Changes over time in the reported risk for childhood leukaemia and magnetic fields. J Radiol Prot 2019;39:470–88. in Google Scholar

63. Fulton, JP, Cobb, S, Preble, L, Leone, L, Forman, E. Electrical wiring configurations and childhood leukemia in Rhode Island. Am J Epidemiol 1980;111:292–6. in Google Scholar

64. Fajardo-Gutierrez, A, Velasquez-Perez, L, Martinez-Mendez, J, Martinez-Garcia, C. Exposicion a campos electromagneticos y su asociacion con leucemia en ninos residentes de la ciudad de Mexico. Mexico DF: Unidad de Investigacion Medica en Epidemiologia Clinica Hospital de Pediatria Centro Medico Nacional Siglo XXI; 1997.Search in Google Scholar

65. Florig, HK, Hoburg, JF. Power-frequency magnetic fields from electric blankets. Health Phys 1990;58:493–502. in Google Scholar

66. Wilson, BW, Lee, GM, Yost, MG, Davis, KC, Heimbigner, T, Buschbom, RL. Magnetic field characteristics of electric bed-heating devices. Bioelectromagnetics 1996;17:174–9.<174::aid-bem2>;2-0.10.1002/(SICI)1521-186X(1996)17:3<174::AID-BEM2>3.0.CO;2-0Search in Google Scholar

67. Behrens, T, Terschüren, C, Kaune, WT, Hoffmann, W. Quantification of lifetime accumulated ELF-EMF exposure from household appliances in the context of a retrospective epidemiological case-control study. J Expo Anal Environ Epidemiol 2004;14:144–53. in Google Scholar

68. Delpizzo, V. A model to assess personal exposure to ELF magnetic fields from common household sources. Bioelectromagnetics 1990;11:139–47. in Google Scholar

69. Orkin, S, Fisher, D, Look, AT, Lux, S, Ginsburg, D, Nathan, D. Oncology of infancy and childhood, 1st ed. Philadelphia: Saunders, Elsevier; 2009.Search in Google Scholar

70. Magne, I, Souques, M, Bureau, I, Duburcq, A, Remy, E, Lambrozo, J. Exposure of children to extremely low frequency magnetic fields in France: results of the EXPERS study. J Expo Sci Environ Epidemiol 2017;27:505–12. in Google Scholar PubMed

71. Preece, AW, Kaune, W, Grainger, P, Preece, S, Golding, J. Magnetic fields from domestic appliances in the UK. Phys Med Biol 1997;42:67–76. in Google Scholar PubMed

Supplementary Material

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Received: 2021-08-27
Accepted: 2022-02-13
Published Online: 2022-03-15
Published in Print: 2023-06-27

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