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Licensed Unlicensed Requires Authentication Published online by De Gruyter May 17, 2022

Exposure to air pollution and risk of ovarian cancer: a review

Samaneh Dehghani, Reza Moshfeghinia, Mahsan Ramezani, Mohebat Vali, Vahide Oskoei, Ehsan Amiri-Ardekani and Philip Hopke

Abstract

Objectives

Exposure to air pollution has destructive health consequences and a potential role in ovarian cancer etiology. We conducted a systematic review of the studies assessing the associations between ovarian malignancy and exposure to air pollutants.

Content

The included studies were categorized based on types of measured ambient air pollutants, including particulate matter (five studies), gases (two studies), air pollutant mixtures (eight studies), and traffic indicators for air pollution (only one study). Because of the heterogeneity of quantitative data of the reviewed studies, we qualitatively reviewed the air pollution role in ovarian cancer risk with representing incidence and/or the mortality rate of ovarian cancer in related with air pollution. Nine studies were ecological study design. Except for one, all studies confirmed a positive correlation between exposure to ambient air pollution (AAP) and increased ovarian cancer risks.

Summary

We concluded that prolonged air pollution exposure through possible mechanisms, estrogen-like effects, and genetic mutations might affect ovarian tumorigenesis. This research surveyed the limitations of the previous studies, including issues with ambient air pollution surveillance and assessing the exposure, determining the air pollution sources, data analysis approaches, and study designs.

Outlook

Finally, the authors provide suggestions for future environmental epidemiological inquiries on the impact of exposure to ambient air pollution on ovarian malignancy.


Corresponding authors: Ehsan Amiri-Ardekani, Department of Phytopharmaceutical (Traditional Pharmacy), Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran; Student Association of Indigenous Knowledge, Shiraz University of Medical Sciences, Shiraz, Iran; and School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran, E-mail: ; and Philip Hopke, Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; and Institute for a Sustainable Environment, Clarkson University, Potsdam, NY 13699, USA, E-mail:

Acknowledgments

The authors would like to appreciate all the subjects who participated in the study.

  1. Research funding: No funding was received for this study.

  2. Author contributions: All authors contributed equally to this work.

  3. Competing interests: The authors declare no competing of interest.

  4. Informed consent: Not applicable.

  5. Ethics approval: Not applicable.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/reveh-2021-0129).


Received: 2021-09-19
Accepted: 2022-04-15
Published Online: 2022-05-17

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