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Licensed Unlicensed Requires Authentication Published by De Gruyter June 28, 2022

The effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors

  • Yousef Nikmanesh , Mohammad Javad Mohammadi , Homayon Yousefi , Sara Mansourimoghadam and Masoume Taherian EMAIL logo


Toxic air pollutants are one of the most agent that have many acute, chronic and non-communicable diseases (NCDs) on human health under long or short-term exposure has been raised from the past to the present. The aim of this study was investigation effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors. Databases used to for searched were the PubMed, Web of Science, Springer and Science Direct (Scopus) and Google Scholar. 71 papers based on abstract and article text filtered. In the end after sieve we selected 7 papers. Identify all relevant studies published 1970–2022. The literature showed that exposure to toxic air pollutants and their respiration can cause disorders in different parts of the brain by transmission through the circulatory system and other mechanisms. Various unpleasant abnormalities are caused by the inhalation of toxic air pollutants in the human body that some of the most common of them include chronic lung disease, coronary heart disease and heart attacks, strokes and brain diseases (Parkinson’s, Alzheimer’s and multiple Sclerosis), cancers (liver, blood, prostate and brain) and eventually death. According to the finding brain health and proper functioning can be easily disrupted by various genetic or external factors such as air pollution, causing a wide range of abnormalities in the brain and malignant brain tumors. The results of this study showed that reducing the concentration of toxic pollutants in the air, that exposure to them play an increasing role in the development of brain diseases can slow down the process of abnormalities in the brain and will have significant impacts on reducing the number of people affected by them.

Corresponding author: Masoume Taherian, Department of Environmental Health Engineering, School of Public Health and Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Phone: +989059689031, E-mail:


The authors are grateful to Ahvaz Jundishapur University of Medical Sciences for providing necessary facilities to perform this research.

  1. Research funding: This work wasn’t financially supported.

  2. Author contributions : YN, M-JM, HY, SM, and MT were principal investigators of the study and drafted the manuscript. M-JM, SM and MT were advisors of the study. YN, M-JM, HY, SM and MT performed the statistical analysis. All authors contributed to the design and data analysis and assisted in the preparation of the final version of the manuscript. All authors read and approved the final version of the manuscript.

  3. Competing interests: The authors declare that they have no competing interests.

  4. Informed consent: Not applicable.

  5. Ethical approval: The conducted research is not related to either human or animal use.

  6. Disclosure statement: No potential conflict of interest was reported by the authors.

  7. Consent to participate: ’Not applicable’ for that specific section.


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Received: 2022-02-15
Accepted: 2022-05-16
Published Online: 2022-06-28
Published in Print: 2023-09-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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