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Licensed Unlicensed Requires Authentication Published by De Gruyter March 15, 2013

5-HT1A receptor as a key player in the brain 5-HT system

Nina K. Popova and Vladimir S. Naumenko


Among an impressive variety of identified serotonin receptors, 5-HT1A attracts particular attention due to its central role in the regulation of 5-HT-ergic neurotransmission and the data on its involvement in the mechanisms of stress response, aggressive behavior, anxiety, and depression. This review concentrates on the cross-regulation between 5-HT receptors and the implication of the 5-HT1A receptor in the genetic control of 5-HT-related behavior. Specifically, it describes the (1) functional interactions between 5-HT1A, 5-HT2A, 5-HT3, and 5-HT7 receptors; (2) cross-talk between 5-HT1A receptor and genes encoding key members of the brain 5-HT system; (3) implication of the 5-HT1A receptor in natural hibernation and genetic predisposition to different kinds of defensive behavior; and (4) role of 5-HT1A autoreceptors and heteroreceptors in anxiety, depression, and suicide, and in the antidepressant effect of serotonin reuptake inhibitors. This review provides converging lines of evidence that the 5-HT1A receptor contributes to the action of other 5-HT receptors, modulating their effect on behavior, and describes new data on the unique role of the 5-HT1A receptor in the indirect regulation of gene expression and in the autoregulation of the brain 5-HT system.

Corresponding author: Vladimir S. Naumenko, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Department of Behavioral Neurogenomics, Lavrentieva av. 10, 630090 Novosibirsk, Russia

Received: 2012-10-21
Accepted: 2012-12-27
Published Online: 2013-03-15
Published in Print: 2013-04-01

©2013 by Walter de Gruyter Berlin Boston

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