Accessible Requires Authentication Published by De Gruyter February 6, 2014

Role of caveolin-1 in the biology of the blood-brain barrier

Yong-Lin Zhao, Jin-Ning Song and Ming Zhang


Caveolin-1 is the principal marker of caveolae in endothelial cells. It plays an important role in physiological and pathological conditions of the blood-brain barrier and serves as a mediator in drug delivery through the blood-brain barrier. Caveolin-1 is related to the diminished expression of tight junction-associated proteins and metabolic pinocytosis vesicles when the blood-brain barrier is destroyed by outside invaders or malignant stimulus. The permeability of the blood-brain barrier, regulated by types of drugs or physical irradiation, is connected with drug transportation with the participation of caveolin-1. Caveolin-1, which serves as a platform or medium for signal transduction, cooperates with several signal molecules by forming a complex. Silencing of caveolin-1 and disruption of caveolae can attenuate or remove pathological damage and even engender the opposite effects in the blood-brain barrier. This review considers the role of caveolin-1 in the blood-brain barrier that may have profound implications for central nervous system disease and drug delivery through the blood-brain barrier.

Corresponding author: Jin-Ning Song, Department of Neurosurgery, The First Affiliated Hospital, Medical School of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, Shaanxi 710061, China, e-mail:


All of the authors involved in the preparation of the above manuscript declare no conflict of interest in any form.


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Received: 2013-9-2
Accepted: 2013-12-26
Published Online: 2014-2-6
Published in Print: 2014-4-1

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