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Licensed Unlicensed Requires Authentication Published by De Gruyter July 8, 2017

Mast cells in neuropathic pain: an increasing spectrum of their involvement in pathophysiology

  • Gunjanpreet Kaur , Nirmal Singh and Amteshwar Singh Jaggi EMAIL logo

Abstract

Mast cells are immunological cells that are diversely distributed in different parts of the body. Their role in various pathological conditions such as hypersensitivity, atherosclerosis, pulmonary hypertension, and male infertility has been reported by different scientists. Apart from these, a number of studies have shown their important role in pathogenesis of neuropathic pain of diverse aetiology. They have been found to release active mediators, primarily histamine and serotonin on degranulation in response to different stimuli including chemical, nerve damage, toxin or disease-related conditions. The mast cells stabilizer has shown pain attenuating effects by preventing degranulation of mast cells. Similarly, compound 48/80 (first dose 200 μg/100 g and after 6-h interval, second dose of 500 μg/100 g) caused the degranulation of the accumulated endoneurial histamine and 5-HT antagonists have shown pain relieving effects by attenuating the effects of histamine and serotonin, respectively. On the other hand, the mast cell degranulator compound 48/80 has shown dual action depending on its time of administration. The present review discusses the critical role of mast cells in the generation and maintenance of neuropathic pain in experimental models.

Acknowledgement

The authors are thankful to the Department of Pharmaceutical Sciences and Drug Research, Patiala, India, for support.

References

Anaf, V., Chapron, C., El Nakadi, I., De Moor, V., Simonart, T., and Noël, J.C. (2006). Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis. Fertil. Steril. 86, 1336–1343.10.1016/j.fertnstert.2006.03.057Search in Google Scholar PubMed

Anand, P., Singh, B., Jaggi, A.S., and Singh, N. (2012). Mast cells: an expanding pathophysiological role from allergy to other disorders. Naunyn-Schmiedeberg’s Arch. Pharmacol. 385, 657–670.10.1007/s00210-012-0757-8Search in Google Scholar

Bennett, G.J. (1998). Neuropathic pain: new insights, new interventions. Hosp. Pract. 33, 95–114.10.3810/hp.1998.10.114Search in Google Scholar

Boucher, W., el-Mansoury, M., Pang, X., Sant, G.R., and Theoharides, T.C. (1995). Elevated mast cell tryptase in the urine of patients with interstitial cystitis. Br. J. Urol. 76, 94–100.10.1111/j.1464-410X.1995.tb07840.xSearch in Google Scholar PubMed

Chatterjea, D., Wetzel, A., Mack, M., Engblom, C., Allen, J., Mora-Solano, C., and Martinov, T. (2012). Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice. Biochem. Biophys. Res. Commun. 425, 237–243.10.1016/j.bbrc.2012.07.074Search in Google Scholar PubMed

Cohen, J.M., Fagin, A.P., Hariton, E., Niska, J.R., Pierce, M.W., Kuriyama, A., and Dimitrakoff, J.D. (2012). Therapeutic intervention for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a systematic review and meta-analysis. PLoS One 7, e41941.10.1371/journal.pone.0041941Search in Google Scholar PubMed

Dimitriadou, V., Rouleau, A., Trung Tuong, M.D., Newlands, G.J., Miller, H.R., Luffau, G., Schwartz, J.C., and Garbarg, M. (1997). Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions. Neuroscience 77, 829–839.10.1016/S0306-4522(96)00488-5Search in Google Scholar PubMed

Done, J.D., Rudick, C.N., Quick, M.L., Schaeffer, A.J., and Thumbikat, P. (2012). Role of mast cells in male chronic pelvic pain. J. Urol. 187, 1473–1482.10.1016/j.juro.2011.11.116Search in Google Scholar PubMed PubMed Central

Ehrlich, P. (1878). Beiträge zur Theorie und Praxis der histologischen Färbung. I. Teil: Die chemische Auffassung der Färbung. II. Teil: Die Anilinfarben in Chemischer, Technologischer und Histologischer Beziehung. Doctoral Dissertation (Leipzig, Germany).Search in Google Scholar

Enerbäck, L., Olsson, Y., and Sourander, P. (1965). Mast cells in normal and sectioned peripheral nerve. Z. Zellforsch. Mikrosk. Anat. 66, 596–608.10.1007/BF00368249Search in Google Scholar PubMed

Galli, S.J., Kalesnikoff, J., Grimbaldeston, M.A., Piliponsky, A.M., Williams, C.M.M., and Tsai, M. (2005). Mast cells as “tunable” effector and immunoregulatory cells: Recent Advances. Annu. Rev. Immunol. 23, 749–786.10.1146/annurev.immunol.21.120601.141025Search in Google Scholar PubMed

Kobayashi, T., Miura, T., Haba, T., Sato, M., Serizawa, I., Nagai, H., and Ishizaka, K. (2000). An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J. Immunol. 164, 3855–3861.10.4049/jimmunol.164.7.3855Search in Google Scholar

Levy, D., Kainz, V., Burstein, R., and Strassman, A.M. (2012). Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav. Immun. 26, 311–317.10.1016/j.bbi.2011.09.016Search in Google Scholar PubMed

Liu, T., Bai, Z.T., Pang, X.Y., Chai, Z.F., Jiang, F., and Ji, Y.H. (2007). Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom. Eur. J. Pharmacol. 575, 46–56.10.1016/j.ejphar.2007.07.057Search in Google Scholar PubMed

Metcalfe, D.D., Baram, D., and Mekori, Y.A. (1997). Mast cells. Physiol. Rev. 77, 1033–1079.10.1152/physrev.1997.77.4.1033Search in Google Scholar PubMed

Okragly, A.J., Niles, A.L., Saban, R., Schmidt, D., Hoffman, R.L., Warner, T.F., Moon, T.D., Uehling, D.T., and Haak-Frendscho, M. (1999). Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients. J. Urol. 161, 438–442.10.1016/S0022-5347(01)61915-3Search in Google Scholar PubMed

Oliveira, S.M., Drewes, C.C., Silva, C.R., Trevisan, G., Boschen, S.L., Moreira, C.G., de Almeida Cabrini, D., Da Cunha, C., and Ferreira, J. (2011). Involvement of mast cells in a mouse model of postoperative pain. Eur. J. Pharmacol. 672, 88–95.10.1016/j.ejphar.2011.10.001Search in Google Scholar

Olsson, Y. (1965). Storage of monoamines in mast cells of normal and sectioned peripheral nerve. Z Zellforsch Mikrosk Anat. 68, 255–265.10.1007/BF00342432Search in Google Scholar PubMed

Olsson, Y. (1967). Degranulation of mast cells in peripheral nerve injuries. Acta. Neurol. Scand. 43, 365–374.10.1111/j.1600-0404.1967.tb05739.xSearch in Google Scholar PubMed

Olsson, Y. (1968). Mast cells in the nervous system. Int. Rev. Cytol. 24, 27–70.10.1016/S0074-7696(08)61396-0Search in Google Scholar PubMed

Parada, C.A., Tambeli, C.H., Cunha, F.Q., and Ferreira, S.H. (2001). The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 102, 937–944.10.1016/S0306-4522(00)00523-6Search in Google Scholar PubMed

Rao, K.N. and Brown, M.A. (2008). Mast cells: multifaceted immune cells with diverse roles in health and disease. Ann. N.Y. Acad. Sci. 1143, 83–104.10.1196/annals.1443.023Search in Google Scholar PubMed

Theoharides, T.C., Valent, P., and Akin, C. (2015). Mast cells, mastocytosis, and related disorders. N. Engl. J. Med. 373, 163–172.10.1056/NEJMra1409760Search in Google Scholar PubMed

Treede, R.D., Jensen, T.S., Campbell, J.N., Cruccu, G., Dostrovsky, J.O., Griffin, J.W., and Serra, J. (2008). Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70, 1630–1635.10.1212/01.wnl.0000282763.29778.59Search in Google Scholar

Xanthos, D.N., Gaderer, S., Drdla, R., Nuro, E., Abramova, A., Ellmeier, W., and Sandkühler, J. (2011). Central nervous system mast cells in peripheral inflammatory nociception. Mol. Pain 7, 42.10.1186/1744-8069-7-42Search in Google Scholar PubMed

Zochodne, D.W., Nguyen, C., and Sharkey, K.A. (1994). Accumulation and degranulation of mast cells in experimental neuromas. Neurosci. Lett. 182, 3–6.10.1016/0304-3940(94)90191-0Search in Google Scholar PubMed

Zuo, Y., Perkins, N.M., Tracey, D.J., and Geczy, C.L. (2003). Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells. Pain 105, 467–479.10.1016/S0304-3959(03)00261-6Search in Google Scholar

Received: 2017-2-2
Accepted: 2017-4-4
Published Online: 2017-7-8
Published in Print: 2017-10-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

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