Abstract
White matter injury (WMI) often results in cognitive impairment, behavioral disorders, and cerebral palsy and thus imposes a tremendous burden on society. The cells in brain white matter mainly comprise oligodendrocytes (OLs), astrocytes, and microglia. The dysregulation of OLs development is the pathological hallmark of WMI. Recent studies have demonstrated that microRNAs (miRNAs or miRs) participate in the regulation of OLs development, and the dysregulation of this process represents the pathogenesis of WMI. This review summarizes the progress made in this field that will help clinicians and researchers understand the molecular etiology of WMI and develop miRNAs as new agents for the prevention and treatment of WMI.
Acknowledgments
This work was supported by the National Science Foundation of China (No. 81330016, 81630038, and 81270724), the Major State Basic Research and Development Program (2017YFA0104200 and 2013CB967404), grants from the Science and Technology Bureau of Sichuan province (2014SZ0149 and 2016TD0002), and a grant from the Clinical Discipline Program (Neonatology) from the Ministry of Health of China (1311200003303).
Conflict of interest statement: The authors declare no competing financial interests.
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