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Licensed Unlicensed Requires Authentication Published by De Gruyter February 21, 2018

Biomarkers for detection, prognosis and therapeutic assessment of neurological disorders

  • Sarita Singh

    Dr. Sarita Singh is a Research Associate at Biotech Park, Lucknow, India. She has extensive experience in biomarkers in neurological disease, bioinformatics, computational biology and drug designing. Currently, she is working on identification of neurological biomarkers using bioinformatics applications.

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    , Sunil Kumar Gupta

    Dr. Sunil Kumar Gupta has been working in the area of infectious diseases of the nervous system, computational biology, structural bioinformatics and NGS data analysis since the last 10 years. He is PhD in Bioinformatics from King George’s Medical University, Lucknow, India. He has published more than 12 papers in reputed journals and presented more than 20 research findings in national and international conferences. Currently, he is working with Biotech Park, Lucknow, India as a Research Associate.

    and Prahlad Kishore Seth

    Prof. Prahlad Kishore Seth is an NASI Senior Scientist Platinum Jubilee fellow at Biotech Park, Lucknow, India. Prof. Seth is an outstanding scientist and has made significant contributions to toxicology, neurosciences, molecular biology and biotechnology. One of his findings showed the presence of dopamine (DA) D2 and serotonin (5-HT2A) receptors in human platelet membranes and nitric oxide in PMNs with pharmacological responsiveness similar to the brain. His current research focuses on neurological disorders, biomarkers and bioinformatics related area.


Neurological disorders have aroused a significant concern among the health scientists globally, as diseases such as Parkinson’s, Alzheimer’s and dementia lead to disability and people have to live with them throughout the life. Recent evidence suggests that a number of environmental chemicals such as pesticides (paraquat) and metals (lead and aluminum) are also the cause of these diseases and other neurological disorders. Biomarkers can help in detecting the disorder at the preclinical stage, progression of the disease and key metabolomic alterations permitting identification of potential targets for intervention. A number of biomarkers have been proposed for some neurological disorders based on laboratory and clinical studies. In silico approaches have also been used by some investigators. Yet the ideal biomarker, which can help in early detection and follow-up on treatment and identifying the susceptible populations, is not available. An attempt has therefore been made to review the recent advancements of in silico approaches for discovery of biomarkers and their validation. In silico techniques implemented with multi-omics approaches have potential to provide a fast and accurate approach to identify novel biomarkers.

About the authors

Sarita Singh

Dr. Sarita Singh is a Research Associate at Biotech Park, Lucknow, India. She has extensive experience in biomarkers in neurological disease, bioinformatics, computational biology and drug designing. Currently, she is working on identification of neurological biomarkers using bioinformatics applications.

Sunil Kumar Gupta

Dr. Sunil Kumar Gupta has been working in the area of infectious diseases of the nervous system, computational biology, structural bioinformatics and NGS data analysis since the last 10 years. He is PhD in Bioinformatics from King George’s Medical University, Lucknow, India. He has published more than 12 papers in reputed journals and presented more than 20 research findings in national and international conferences. Currently, he is working with Biotech Park, Lucknow, India as a Research Associate.

Prahlad Kishore Seth

Prof. Prahlad Kishore Seth is an NASI Senior Scientist Platinum Jubilee fellow at Biotech Park, Lucknow, India. Prof. Seth is an outstanding scientist and has made significant contributions to toxicology, neurosciences, molecular biology and biotechnology. One of his findings showed the presence of dopamine (DA) D2 and serotonin (5-HT2A) receptors in human platelet membranes and nitric oxide in PMNs with pharmacological responsiveness similar to the brain. His current research focuses on neurological disorders, biomarkers and bioinformatics related area.


We wish to thank National Academy of Sciences India (NASI), Allahabad, for their financial support as NASI Senior Scientist Platinum Jubilee Fellowship and also Biotech Park, Lucknow, India, for providing workspace, Grant Number: NAS/396/11/2016-17.


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Received: 2017-11-10
Accepted: 2017-12-17
Published Online: 2018-02-21
Published in Print: 2018-09-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

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