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Licensed Unlicensed Requires Authentication Published by De Gruyter January 8, 2019

Functions of adiponectin signaling in regulating neural plasticity and its application as the therapeutic target to neurological and psychiatric diseases

Li-na Sun and Xiao-li Liu


Convergent lines of evidence indicate the critical roles of adiponectin in regulating neural functions on different levels. Because of the importance in maintaining neural plasticity including adult neurogenesis and synaptic plasticity, adiponectin has the potential to serve as the treatment targets in therapies of neurological and psychiatric disorders. Hence, systematic review is needed to summarize how adiponectin works in the brain, and how the adiponectin pathway is employed as the treatment method needs to be determined. Moreover, the benefits of adiponectin as the regulator for neural plasticity such as synaptic plasticity and neurogenesis have been supported by many literatures. In the current article, we reviewed the functions of adiponectin in different types of neural plasticity. We also demonstrated the potential value of adiponectin as the treatment target for different types of neurodegenerative and psychiatric disorders. Taken together, this review offers a new insight about adiponectin as the ideal target to develop the new treatment methods against neurodegeneration or psychiatric diseases.

Funding source: National Natural Science Foundation of China

Award Identifier / Grant number: 31571221

Funding statement: This study was supported by National Natural Science Foundation of China (31571221), the China Postdoctoral Science Fund (2014M560198) and Fundamental Research Funds for the Central Universities (2018NTSS30).

  1. Conflict of interest statement: No conflict of interest exists among the authors regarding this article.


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Received: 2018-06-20
Accepted: 2018-10-06
Published Online: 2019-01-08
Published in Print: 2019-07-26

©2019 Walter de Gruyter GmbH, Berlin/Boston

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