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Licensed Unlicensed Requires Authentication Published by De Gruyter May 5, 2020

The neurophysiology of ketamine: an integrative review

Rebecca McMillan ORCID logo and Suresh D. Muthukumaraswamy

Abstract

The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of psychosis and, most recently, its antidepressant properties. Understanding the physiology of ketamine is complex due to its rich pharmacology with multiple potential sites at clinically relevant doses. In this review of the neurophysiology of ketamine, we focus on the acute effects of ketamine in the resting brain. We ascend through spatial scales starting with a complete review of the pharmacology of ketamine and then cover its effects on in vitro and in vivo electrophysiology. We then summarise and critically evaluate studies using EEG/MEG and neuroimaging measures (MRI and PET), integrating across scales where possible. While a complicated and, at times, confusing picture of ketamine’s effects are revealed, we stress that much of this might be caused by use of different species, doses, and analytical methodologies and suggest strategies that future work could use to answer these problems.

Acknowledgments

Dr Muthukumaraswamy is supported by a Rutherford Discovery Fellowship administered by the Royal Society of New Zealand. This work was supported by the Health Research Council of New Zealand.

References

Aalkjær, C., Boedtkjer, D., and Matchkov, V. (2011). Vasomotion – what is currently thought? Acta Physiol. 202, 253–269.10.1111/j.1748-1716.2011.02320.xSearch in Google Scholar PubMed

Abdallah, C.G., Averill, L.A., and Krystal, J.H. (2015). Ketamine as a promising prototype for a new generation of rapid-acting antidepressants. Ann. N.Y. Acad. Sci. 1344, 66–77.10.1111/nyas.12718Search in Google Scholar PubMed PubMed Central

Abdallah, C.G., Averill, L.A., Collins, K.A., Geha, P., Schwartz, J., Averill, C., DeWilde, K.E., Wong, E., Anticevic, A., and Tang, C.Y. (2016). Ketamine treatment and global brain connectivity in major depression. Neuropsychopharmacology 42, 1210.10.1038/npp.2016.186Search in Google Scholar PubMed PubMed Central

Abdallah, C.G., De Feyter, H.M., Averill, L.A., Jiang, L., Averill, C.L., Chowdhury, G.M., Purohit, P., de Graaf, R.A., Esterlis, I., and Juchem, C. (2018a). The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 1.10.1038/s41386-018-0136-3Search in Google Scholar PubMed PubMed Central

Abdallah, C.G., Dutta, A., Averill, C.L., McKie, S., Akiki, T.J., Averill, L.A., and William Deakin, J.F. (2018b). Ketamine, but not the NMDAR antagonist lanicemine, increases prefrontal global connectivity in depressed patients. Chronic Stress 2, 2470547018796102.10.1177/2470547018796102Search in Google Scholar PubMed PubMed Central

Ahnaou, A., Huysmans, H., Biermans, R., Manyakov, N.V., and Drinkenburg, W. (2017). Ketamine: differential neurophysiological dynamics in functional networks in the rat brain. Transl. Psychiatry 7, e1237.10.1038/tp.2017.198Search in Google Scholar PubMed PubMed Central

Alsop, D.C., Detre, J.A., Golay, X., Günther, M., Hendrikse, J., Hernandez-Garcia, L., Lu, H., MacIntosh, B.J., Parkes, L.M., Smits, M., et al. (2015). Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn. Reson. Med. 73, 102–116.10.1002/mrm.25197Search in Google Scholar PubMed PubMed Central

Amat-Foraster, M., Jensen, A.A., Plath, N., Herrik, K.F., Celada, P., and Artigas, F. (2018). Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks. Neuropharmacology 137, 13–23.10.1016/j.neuropharm.2018.04.022Search in Google Scholar PubMed

Anderson, P.M., Jones, N.C., O’brien, T.J., and Pinault, D. (2016). The n-methyl d-aspartate glutamate receptor antagonist ketamine disrupts the functional state of the corticothalamic pathway. Cereb. Cortex 27, 3172–3185.10.1093/cercor/bhw168Search in Google Scholar PubMed

Anticevic, A., Corlett, P.R., Cole, M.W., Savic, A., Gancsos, M., Tang, Y., Repovs, G., Murray, J.D., Driesen, N.R., and Morgan, P.T. (2015). N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia. Biol. Psychiatry 77, 569–580.10.1016/j.biopsych.2014.07.022Search in Google Scholar PubMed

Anver, H., Ward, P.D., Magony, A., and Vreugdenhil, M. (2011). NMDA receptor hypofunction phase couples independent γ-oscillations in the rat visual cortex. Neuropsychopharmacology 36, 519.10.1038/npp.2010.183Search in Google Scholar

Arnal, L.H. and Giraud, A.-L. (2012). Cortical oscillations and sensory predictions. Trends Cogn. Sci. 16, 390–398.10.1016/j.tics.2012.05.003Search in Google Scholar

Ballard, E.D., Lally, N., Nugent, A.C., Furey, M.L., Luckenbaugh, D.A., and Zarate, C.A. (2015). Neural correlates of suicidal ideation and its reduction in depression. Int. J. Neuropsychopharmacol. 18, pyu069–pyu069.10.1093/ijnp/pyu069Search in Google Scholar

Bartos, M., Vida, I., and Jonas, P. (2007). Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks. Nat. Rev. Neurosci. 8, 45.10.1038/nrn2044Search in Google Scholar

Becker, D.E. and Reed, K.L. (2012). Local anesthetics: review of pharmacological considerations. Anesth. Prog. 59, 90–102.10.2344/0003-3006-59.2.90Search in Google Scholar

Berman, R.M., Cappiello, A., Anand, A., Oren, D.A., Heninger, G.R., Charney, D.S., and Krystal, J.H. (2000). Antidepressant effects of ketamine in depressed patients. Biol. Psychiatry 47, 351–354.10.1016/S0006-3223(99)00230-9Search in Google Scholar

Blain-Moraes, S., Lee, U., Ku, S., Noh, G., and Mashour, G.A. (2014). Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth. Front. Syst. Neurosci. 8, 114.10.3389/fnsys.2014.00114Search in Google Scholar PubMed PubMed Central

Bliss, T.V. and Collingridge, G.L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31.10.1038/361031a0Search in Google Scholar PubMed

Bliss, T.V. and Lømo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. 232, 331–356.10.1113/jphysiol.1973.sp010273Search in Google Scholar PubMed PubMed Central

Bojak, I., Day, H.C., and Liley, D.T. (2013). Ketamine, propofol, and the EEG: a neural field analysis of HCN1-mediated interactions. Front. Comput. Neurosci. 7.10.3389/fncom.2013.00022Search in Google Scholar PubMed PubMed Central

Bojesen, K.B., Andersen, K.A., Rasmussen, S.N., Baandrup, L., Madsen, L.M., Glenthøj, B.Y., Rostrup, E., and Broberg, B.V. (2018). Glutamate levels and resting cerebral blood flow in anterior cingulate cortex are associated at rest and immediately following infusion of s-ketamine in healthy volunteers. Front. Psychiatry 9, 22.10.3389/fpsyt.2018.00022Search in Google Scholar

Bollimunta, A., Chen, Y., Schroeder, C.E., and Ding, M. (2008). Neuronal mechanisms of cortical alpha oscillations in awake-behaving macaques. J. Neurosci. 28, 9976–9988.10.1523/JNEUROSCI.2699-08.2008Search in Google Scholar

Bollimunta, A., Mo, J., Schroeder, C.E., and Ding, M. (2011). Neuronal mechanisms and attentional modulation of corticothalamic alpha oscillations. J. Neurosci. Off. J. Soc. Neurosci. 31, 4935–4943.10.1523/JNEUROSCI.5580-10.2011Search in Google Scholar

Bonhomme, V., Vanhaudenhuyse, A., Demertzi, A., Bruno, M.-A., Jaquet, O., Bahri, M.A., Plenevaux, A., Boly, M., Boveroux, P., and Soddu, A. (2016). Resting-state network-specific breakdown of functional connectivity during ketamine alteration of consciousness in volunteers. J. Am. Soc. Anesthesiol. 125, 873–888.10.1097/ALN.0000000000001275Search in Google Scholar

Boothman, L., Raley, J., Denk, F., Hirani, E., and Sharp, T. (2006). In vivo evidence that 5-HT2C receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. Br. J. Pharmacol. 149, 861–869.10.1038/sj.bjp.0706935Search in Google Scholar

Bowen, W.D. (2000). Sigma receptors: recent advances and new clinical potentials. Pharm. Acta Helv. 74, 211–218.10.1016/S0165-7208(00)80020-3Search in Google Scholar

Breier, A., Adler, C.M., Weisenfeld, N., Su, T.-P., Elman, I., Picken, L., Malhotra, A.K., and Pickar, D. (1998). Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach. Synapse 29, 142–147.10.1002/(SICI)1098-2396(199806)29:2<142::AID-SYN5>3.0.CO;2-7Search in Google Scholar

Bright, M.G. and Murphy, K. (2015). Is fMRI “noise” really noise? Resting state nuisance regressors remove variance with network structure. Neuroimage 114, 158–169.10.1016/j.neuroimage.2015.03.070Search in Google Scholar

Bright, M.G., Bulte, D.P., Jezzard, P., and Duyn, J.H. (2009). Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and BOLD fMRI. NeuroImage 48, 166–175.10.1016/j.neuroimage.2009.05.026Search in Google Scholar

Brosch, J.R., Talavage, T.M., Ulmer, J.L., and Nyenhuis, J.A. (2002). Simulation of human respiration in fMRI with a mechanical model. IEEE Trans. Biomed. Eng. 49, 700–707.10.1109/TBME.2002.1010854Search in Google Scholar

Browne, C.A. and Lucki, I. (2013). Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants. Front. Pharmacol. 4.10.3389/fphar.2013.00161Search in Google Scholar PubMed PubMed Central

Buffalo, E.A., Fries, P., Landman, R., Buschman, T.J., and Desimone, R. (2011). Laminar differences in gamma and alpha coherence in the ventral stream. Proc. Natl. Acad. Sci. 108, 11262–11267.10.1073/pnas.1011284108Search in Google Scholar PubMed PubMed Central

Buxton, R.B. (2009). Introduction to Functional Magnetic Resonance Imaging: Principles and Techniques (Cambridge and New York: Cambridge University Press).10.1017/CBO9780511605505Search in Google Scholar

Buxton, R.B. (2013). The physics of functional magnetic resonance imaging (fMRI). Rep. Prog. Phys. Phys. Soc. G. B. 76, 096601.10.1088/0034-4885/76/9/096601Search in Google Scholar PubMed PubMed Central

Buzsáki, G. and Draguhn, A. (2004). Neuronal oscillations in cortical networks. Science 304, 1926–1929.10.1126/science.1099745Search in Google Scholar PubMed

Buzsáki, G. and Wang, X.-J. (2012). Mechanisms of gamma oscillations. Annu. Rev. Neurosci. 35, 203–225.10.1146/annurev-neuro-062111-150444Search in Google Scholar PubMed PubMed Central

Buzsaki, G., Bickford, R.G., Ponomareff, G., Thal, L.J., Mandel, R., and Gage, F.H. (1988). Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J. Neurosci. Off. J. Soc. Neurosci. 8, 4007–4026.10.1523/JNEUROSCI.08-11-04007.1988Search in Google Scholar

Buzsáki, G., Anastassiou, C.A., and Koch, C. (2012). The origin of extracellular fields and currents – EEG, ECoG, LFP and spikes. Nat. Rev. Neurosci. 13, 407.10.1038/nrn3241Search in Google Scholar PubMed PubMed Central

Caixeta, F.V., Cornélio, A.M., Scheffer-Teixeira, R., Ribeiro, S., and Tort, A.B. (2013). Ketamine alters oscillatory coupling in the hippocampus. Sci. Rep. 3, 2348.10.1038/srep02348Search in Google Scholar PubMed PubMed Central

Can, A., Zanos, P., Moaddel, R., Kang, H.J., Dossou, K.S., Wainer, I.W., Cheer, J.F., Frost, D.O., Huang, X.-P., and Gould, T.D. (2016). Effects of ketamine and ketamine metabolites on evoked striatal dopamine release, dopamine receptors, and monoamine transporters. J. Pharmacol. Exp. Ther. 359, 159–170.10.1124/jpet.116.235838Search in Google Scholar PubMed PubMed Central

Canolty, R.T. and Knight, R.T. (2010). The functional role of cross-frequency coupling. Trends Cogn. Sci. 14, 506–515.10.1016/j.tics.2010.09.001Search in Google Scholar PubMed PubMed Central

Carlson, P.J., Diazgranados, N., Nugent, A.C., Ibrahim, L., Luckenbaugh, D.A., Brutsche, N., Herscovitch, P., Manji, H.K., Zarate Jr, C.A., and Drevets, W.C. (2013). Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: a preliminary positron emission tomography study. Biol. Psychiatry 73, 1213–1221.10.1016/j.biopsych.2013.02.008Search in Google Scholar PubMed PubMed Central

Cavanagh, J.F. and Frank, M.J. (2014). Frontal theta as a mechanism for cognitive control. Trends Cogn. Sci. 18, 414–421.10.1016/j.tics.2014.04.012Search in Google Scholar PubMed PubMed Central

Chen, X., Shu, S., and Bayliss, D.A. (2009). HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. J. Neurosci. 29, 600–609.10.1523/JNEUROSCI.3481-08.2009Search in Google Scholar PubMed PubMed Central

Chin, C.-L., Upadhyay, J., Marek, G.J., Baker, S.J., Zhang, M., Mezler, M., Fox, G.B., and Day, M. (2011). Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine-induced blood oxygenation level dependence signals. J. Pharmacol. Exp. Ther. 336, 709–715.10.1124/jpet.110.173880Search in Google Scholar PubMed

Chowdhury, G.M.I., Behar, K.L., Cho, W., Thomas, M.A., Rothman, D.L., and Sanacora, G. (2012). 1H-[13C]-nuclear magnetic resonance spectroscopy measures of ketamine’s effect on amino acid neurotransmitter metabolism. Biol. Psychiatry 71, 1022–1025.10.1016/j.biopsych.2011.11.006Search in Google Scholar PubMed PubMed Central

Clements, J.A. and Nimmo, W.S. (1981). Pharmacokinetics and analgesic effect of ketamine in man. Br. J. Anaesth. 53, 27–30.10.1093/bja/53.1.27Search in Google Scholar PubMed

Clements, J.A., Nimmo, W.S., and Grant, I.S. (1982). Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. J. Pharm. Sci. 71, 539–542.10.1002/jps.2600710516Search in Google Scholar PubMed

Cohen, S.M., Tsien, R.W., Goff, D.C., and Halassa, M.M. (2015). The impact of NMDA receptor hypofunction on GABAergic interneurons in the pathophysiology of schizophrenia. Schizophr. Res. 167, 98–107.10.1016/j.schres.2014.12.026Search in Google Scholar PubMed PubMed Central

Colgin, L.L. (2013). Mechanisms and functions of theta rhythms. Annu. Rev. Neurosci. 36, 295–312.10.1146/annurev-neuro-062012-170330Search in Google Scholar PubMed

Cordes, D., Haughton, V.M., Arfanakis, K., Carew, J.D., Turski, P.A., Moritz, C.H., and Quigley, M.A. (2001). Frequencies contributing to functional connectivity in the cerebral cortex in “resting-state” data. 8.Search in Google Scholar

Corsi-Cabrera, M., Pérez-Garci, E., Río-Portilla, Y.D., Ugalde, E., and Guevara, M.A. (2001). EEG bands during wakefulness, slow-wave, and paradoxical sleep as a result of principal component analysis in the rat. Sleep 24, 374–380.10.1093/sleep/24.4.374Search in Google Scholar

Corssen, G. and Domino, E.F. (1966). Dissociative anesthesia: further pharmacologic studies and first clinical experience with the phencyclidine derivative Cl-581. Anesth. Analg. 45, 29–40.10.1213/00000539-196601000-00007Search in Google Scholar

Da Silva, F.L., Van Lierop, T., Schrijer, C.F., and Van Leeuwen, W.S. (1973). Organization of thalamic and cortical alpha rhythms: spectra and coherences. Electroencephalogr. Clin. Neurophysiol. 35, 627–639.10.1016/0013-4694(73)90216-2Search in Google Scholar

Dagli, M.S., Ingeholm, J.E., and Haxby, J.V. (1999). Localization of cardiac-induced signal change in fMRI. Neuroimage 9, 407–415.10.1006/nimg.1998.0424Search in Google Scholar PubMed

Dalal, S.S., Jerbi, K., Bertrand, O., Adam, C., Ducorps, A., Schwartz, D., Garnero, L., Baillet, S., Martinerie, J., and Lachaux, J.-P. (2013). Evidence for MEG detection of hippocampus oscillations and cortical gamma-band activity from simultaneous intracranial EEG. Epilepsy Behav. 28, 310–311.10.1016/j.yebeh.2012.04.032Search in Google Scholar

Dandash, O., Harrison, B.J., Adapa, R., Gaillard, R., Giorlando, F., Wood, S.J., Fletcher, P.C., and Fornito, A. (2015). Selective augmentation of striatal functional connectivity following NMDA receptor antagonism: implications for psychosis. Neuropsychopharmacology 40, 622.10.1038/npp.2014.210Search in Google Scholar PubMed PubMed Central

Davis, L., Britten, J.J., and Morgan, M. (1997). Cholinesterase. Its significance in anaesthetic practice. Anaesthesia 52, 244–260.10.1111/j.1365-2044.1997.084-az0080.xSearch in Google Scholar PubMed

Davis, T.L., Kwong, K.K., Weisskoff, R.M., and Rosen, B.R. (1998). Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc. Natl. Acad. Sci. USA 95, 1834–1839.10.1073/pnas.95.4.1834Search in Google Scholar PubMed PubMed Central

Dawson, N., Morris, B.J., and Pratt, J.A. (2013). Subanaesthetic ketamine treatment alters prefrontal cortex connectivity with thalamus and ascending subcortical systems. Schizophr. Bull. 39, 366–377.10.1093/schbul/sbr144Search in Google Scholar PubMed PubMed Central

de la Salle, S., Choueiry, J., Shah, D., Bowers, H., McIntosh, J., Ilivitsky, V., and Knott, V. (2016). Effects of ketamine on resting-state EEG activity and their relationship to perceptual/dissociative symptoms in healthy humans. Front. Pharmacol. 7, 348.10.3389/fphar.2016.00348Search in Google Scholar PubMed PubMed Central

De Simoni, S., Schwarz, A.J., O’Daly, O.G., Marquand, A.F., Brittain, C., Gonzales, C., Stephenson, S., Williams, S.C., and Mehta, M.A. (2013). Test–retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers. Neuroimage 64, 75–90.10.1016/j.neuroimage.2012.09.037Search in Google Scholar PubMed

Deakin, J.W., Lees, J., McKie, S., Hallak, J.E., Williams, S.R., and Dursun, S.M. (2008). Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco–magnetic resonance imaging study. Arch. Gen. Psychiatry 65, 154–164.10.1001/archgenpsychiatry.2007.37Search in Google Scholar PubMed

Dehaene, S. and Changeux, J.-P. (2011). Experimental and theoretical approaches to conscious processing. Neuron 70, 200–227.10.1016/j.neuron.2011.03.018Search in Google Scholar PubMed

Del Arco, A., Segovia, G., and Mora, F. (2008). Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity. Psychopharmacology (Berl.) 201, 325–338.10.1007/s00213-008-1288-3Search in Google Scholar PubMed

DeWilde, K.E., Levitch, C.F., Murrough, J.W., Mathew, S.J., and Iosifescu, D.V. (2015). The promise of ketamine for treatment-resistant depression: current evidence and future directions. Ann. N. Y. Acad. Sci. 1345, 47–58.10.1111/nyas.12646Search in Google Scholar PubMed PubMed Central

Dimpfel, W. and Spüler, M. (1990). Dizocilpine (MK-801), ketamine and phencyclidine: low doses affect brain field potentials in the freely moving rat in the same way as activation of dopaminergic transmission. Psychopharmacology (Berl.) 101, 317–323.10.1007/BF02244048Search in Google Scholar PubMed

Dimpfel, W., Spüler, M., Koch, R., and Schatton, W. (1987). Radioelectroencephalographic comparison of memantine with receptor-specific drugs acting on dopaminergic transmission in freely moving rats. Neuropsychobiology 18, 212–218.10.1159/000118420Search in Google Scholar PubMed

Domino, E.F., Chodoff, P., and Corssen, G. (1965). Pharmacologic effects of CI-581, a new dissociative anesthetic, in man. Clin. Pharmacol. Ther. 6, 279–291.10.1002/cpt196563279Search in Google Scholar PubMed

Downey, D., Dutta, A., McKie, S., Dawson, G.R., Dourish, C.T., Craig, K., Smith, M.A., McCarthy, D.J., Harmer, C.J., and Goodwin, G.M. (2016). Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate. Eur. Neuropsychopharmacol. 26, 994–1003.10.1016/j.euroneuro.2016.03.006Search in Google Scholar PubMed

Doyle, O.M., De Simoni, S., Schwarz, A.J., Brittain, C., O’Daly, O.G., Williams, S.C.R., and Mehta, M.A. (2013). Quantifying the attenuation of the ketamine pharmacological magnetic resonance imaging response in humans: a validation using antipsychotic and glutamatergic agents. J. Pharmacol. Exp. Ther. 345, 151–160.10.1124/jpet.112.201665Search in Google Scholar PubMed

Drevets, W.C., Savitz, J., and Trimble, M. (2008). The subgenual anterior cingulate cortex in mood disorders. CNS Spectr. 13, 663.10.1017/S1092852900013754Search in Google Scholar

Driesen, N.R., McCarthy, G., Bhagwagar, Z., Bloch, M., Calhoun, V., D’Souza, D.C., Gueorguieva, R., He, G., Ramachandran, R., and Suckow, R.F. (2013). Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Mol. Psychiatry 18, 1199–1204.10.1038/mp.2012.194Search in Google Scholar

Duman, R.S., Li, N., Liu, R.-J., Duric, V., and Aghajanian, G. (2012). Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology 62, 35–41.10.1016/j.neuropharm.2011.08.044Search in Google Scholar

Durieux, M.E. (1995). Inhibition by ketamine of muscarinic acetylcholine receptor function. Anesth. Analg. 81, 57–62.Search in Google Scholar

Ebert, B., Mikkelsen, S., Thorkildsen, C., and Borgbjerg, F.M. (1997). Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur. J. Pharmacol. 333, 99–104.10.1016/S0014-2999(97)01116-3Search in Google Scholar

Ehrlichman, R.S., Gandal, M.J., Maxwell, C.R., Lazarewicz, M.T., Finkel, L.H., Contreras, D., Turetsky, B.I., and Siegel, S.J. (2009). N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia. Neuroscience 158, 705–712.10.1016/j.neuroscience.2008.10.031Search in Google Scholar PubMed

Einevoll, G.T., Kayser, C., Logothetis, N.K., and Panzeri, S. (2013). Modelling and analysis of local field potentials for studying the function of cortical circuits. Nat. Rev. Neurosci. 14, 770.10.1038/nrn3599Search in Google Scholar PubMed

Engel, A.K. and Fries, P. (2010). Beta-band oscillations – signalling the status quo? Curr. Opin. Neurobiol. 20, 156–165.10.1016/j.conb.2010.02.015Search in Google Scholar PubMed

Engelhard, K., Werner, C., Möllenberg, O., and Kochs, E. (2001). S (+)-ketamine/propofol maintain dynamic cerebrovascular autoregulation in humans. Can. J. Anaesth. 48, 1034.10.1007/BF03016597Search in Google Scholar PubMed

Ernst, T. and Hennig, J. (1994). Observation of a fast response in functional MR. Magn. Reson. Med. 32, 146–149.10.1002/mrm.1910320122Search in Google Scholar PubMed

Evans, J.W., Szczepanik, J., Brutsché, N., Park, L.T., Nugent, A.C., and Zarate, C.A. (2018). Default mode connectivity in major depressive disorder measured up to 10 days after ketamine administration. Biol. Psychiatry 84, 582–590.10.1016/j.biopsych.2018.01.027Search in Google Scholar PubMed PubMed Central

Farde, L.M., Nyberg, S., Oxenstierna, G., Nakashima, Y., Halldin, C.P., and Ericsson, B. (1995). Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients. J. Clin. Psychopharmacol. 15, 19–23.10.1097/00004714-199502001-00004Search in Google Scholar PubMed

Fleming, L.M., Javitt, D.C., Carter, C.S., Kantrowitz, J.T., Girgis, R.R., Kegeles, L.S., Ragland, J.D., Maddock, R.J., Lesh, T.A., Tanase, C., et al. (2019). A multicenter study of ketamine effects on functional connectivity: large scale network relationships, hubs and symptom mechanisms. NeuroImage Clin. 22, 101739.10.1016/j.nicl.2019.101739Search in Google Scholar PubMed PubMed Central

Flint, A.C. and Connors, B.W. (1996). Two types of network oscillations in neocortex mediated by distinct glutamate receptor subtypes and neuronal populations. J. Neurophysiol. 75, 951–957.10.1152/jn.1996.75.2.951Search in Google Scholar PubMed

Flood, P. and Krasowski, M.D. (2000). Intravenous anesthetics differentially modulate ligand-gated ion channels. Anesthesiol. J. Am. Soc. Anesthesiol. 92, 1418–1425.10.1097/00000542-200005000-00033Search in Google Scholar PubMed

Forman, S.A. and Chin, V.A. (2008). General anesthetics and molecular mechanisms of unconsciousness. Int. Anesthesiol. Clin. 46, 43.10.1097/AIA.0b013e3181755da5Search in Google Scholar PubMed PubMed Central

Fornito, A., Zalesky, A., and Breakspear, M. (2015). The connectomics of brain disorders. Nat. Rev. Neurosci. 16, 159.10.1038/nrn3901Search in Google Scholar PubMed

Forsyth, A., McMillan, R., Campbell, D., Malpas, G., Maxwell, E., Sleigh, J., Dukart, J., Hipp, J.F., and Muthukumaraswamy, S.D. (2018). Comparison of local spectral modulation, and temporal correlation, of simultaneously recorded EEG/fMRI signals during ketamine and midazolam sedation. Psychopharmacology (Berl.) 235, 1–15.10.1007/s00213-018-5064-8Search in Google Scholar PubMed

Fox, M.D., Snyder, A.Z., Vincent, J.L., Corbetta, M., Van Essen, D.C., and Raichle, M.E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc. Natl. Acad. Sci. U. S. A. 102, 9673–9678.10.1073/pnas.0504136102Search in Google Scholar PubMed PubMed Central

Frahm, J., Krüger, G., Merboldt, K.-D., and Kleinschmidt, A. (1996). Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. Magn. Reson. Med. 35, 143–148.10.1002/mrm.1910350202Search in Google Scholar PubMed

Friston, K.J., Williams, S., Howard, R., Frackowiak, R.S., and Turner, R. (1996). Movement-related effects in fMRI time-series. Magn. Reson. Med. 35, 346–355.10.1002/mrm.1910350312Search in Google Scholar PubMed

Friston, K.J., Harrison, L., and Penny, W. (2003). Dynamic causal modelling. NeuroImage 19, 1273–1302.10.1016/S1053-8119(03)00202-7Search in Google Scholar

Frohlich, J. and Van Horn, J.D. (2014). Reviewing the ketamine model for schizophrenia. J. Psychopharmacol. (Oxf.) 28, 287–302.10.1177/0269881113512909Search in Google Scholar PubMed PubMed Central

Fu, C.H.Y., Steiner, H., and Costafreda, S.G. (2013). Predictive neural biomarkers of clinical response in depression: a meta-analysis of functional and structural neuroimaging studies of pharmacological and psychological therapies. Neurobiol. Dis. 52, 75–83.10.1016/j.nbd.2012.05.008Search in Google Scholar PubMed

Garrido, M.I., Kilner, J.M., Kiebel, S.J., and Friston, K.J. (2007). Evoked brain responses are generated by feedback loops. Proc. Natl. Acad. Sci. 104, 20961–20966.10.1073/pnas.0706274105Search in Google Scholar PubMed PubMed Central

Gärtner, M., Aust, S., Bajbouj, M., Fan, Y., Wingenfeld, K., Otte, C., Heuser-Collier, I., Böker, H., Hättenschwiler, J., Seifritz, E., et al. (2019). Functional connectivity between prefrontal cortex and subgenual cingulate predicts antidepressant effects of ketamine. Eur. Neuropsychopharmacol.10.1016/j.euroneuro.2019.02.008Search in Google Scholar PubMed

Gass, N., Schwarz, A.J., Sartorius, A., Schenker, E., Risterucci, C., Spedding, M., Zheng, L., Meyer-Lindenberg, A., and Weber-Fahr, W. (2014). Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat. Neuropsychopharmacology 39, 895–906.10.1038/npp.2013.290Search in Google Scholar PubMed PubMed Central

Gilling, K.E., Jatzke, C., Hechenberger, M., and Parsons, C.G. (2009). Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-d-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors. Neuropharmacology 56, 866–875.10.1016/j.neuropharm.2009.01.012Search in Google Scholar PubMed

Godsil, B.P., Kiss, J.P., Spedding, M., and Jay, T.M. (2013). The hippocampal–prefrontal pathway: the weak link in psychiatric disorders? Eur. Neuropsychopharmacol. 23, 1165–1181.10.1016/j.euroneuro.2012.10.018Search in Google Scholar PubMed

Goense, J.B.M. and Logothetis, N.K. (2008). Neurophysiology of the BOLD fMRI signal in awake monkeys. Curr. Biol. 18, 631–640.10.1016/j.cub.2008.03.054Search in Google Scholar PubMed

Gonzalez-Burgos, G. and Lewis, D.A. (2012). NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia. Schizophr. Bull. 38, 950–957.10.1093/schbul/sbs010Search in Google Scholar PubMed PubMed Central

Gopinath, K., Maltbie, E., Urushino, N., Kempf, D., and Howell, L. (2016). Ketamine-induced changes in connectivity of functional brain networks in awake female nonhuman primates: a translational functional imaging model. Psychopharmacology (Berl.) 233, 3673–3684.10.1007/s00213-016-4401-zSearch in Google Scholar

Gorman, J.M. (1996). Comorbid depression and anxiety spectrum disorders. Depress. Anxiety 4, 160–168.10.1002/(SICI)1520-6394(1996)4:4<160::AID-DA2>3.0.CO;2-JSearch in Google Scholar

Grace, R.F. (2003). The effect of variable-dose diazepam on dreaming and emergence phenomena in 400 cases of ketamine-fentanyl anaesthesia. Anaesthesia 58, 904–910.10.1046/j.1365-2044.2003.03341.xSearch in Google Scholar

Grant, I.S., Nimmo, W.S., Mcnicol, L.R., and Clements, J.A. (1983). Ketamine disposition in children and adults. Br. J. Anaesth. 55, 1107–1111.10.1093/bja/55.11.1107Search in Google Scholar

Grent-‘t-Jong, T., Rivolta, D., Gross, J., Gajwani, R., Lawrie, S.M., Schwannauer, M., Heidegger, T., Wibral, M., Singer, W., and Sauer, A. (2018). Acute ketamine dysregulates task-related gamma-band oscillations in thalamo-cortical circuits in schizophrenia. Brain 141, 2511–2526.10.1093/brain/awy175Search in Google Scholar

Grimm, O., Gass, N., Weber-Fahr, W., Sartorius, A., Schenker, E., Spedding, M., Risterucci, C., Schweiger, J.I., Böhringer, A., and Zang, Z. (2015). Acute ketamine challenge increases resting state prefrontal-hippocampal connectivity in both humans and rats. Psychopharmacology (Berl.) 232, 4231–4241.10.1007/s00213-015-4022-ySearch in Google Scholar

Gupta, A., Devi, L.A., and Gomes, I. (2011). Potentiation of μ-opioid receptor-mediated signaling by ketamine. J. Neurochem. 119, 294–302.10.1111/j.1471-4159.2011.07361.xSearch in Google Scholar

Haas, D.A. and Harper, D.G. (1992). Ketamine: a review of its pharmacologic properties and use in ambulatory anesthesia. Anesth. Prog. 39, 61.Search in Google Scholar

Haeseler, G., Tetzlaff, D., Bufler, J., Dengler, R., Münte, S., Hecker, H., and Leuwer, M. (2003). Blockade of voltage-operated neuronal and skeletal muscle sodium channels by S (+)-and R (−)-ketamine. Anesth. Analg. 96, 1019–1026.10.1213/01.ANE.0000052513.91900.D5Search in Google Scholar

Hakami, T., Jones, N.C., Tolmacheva, E.A., Gaudias, J., Chaumont, J., Salzberg, M., O’Brien, T.J., and Pinault, D. (2009). NMDA receptor hypofunction leads to generalized and persistent aberrant γ oscillations independent of hyperlocomotion and the state of consciousness. PLOS One 4, e6755.10.1371/journal.pone.0006755Search in Google Scholar

Han, Y., Chen, J., Zou, D., Zheng, P., Li, Q., Wang, H., Li, P., Zhou, X., Zhang, Y., and Liu, Y. (2016). Efficacy of ketamine in the rapid treatment of major depressive disorder: a meta-analysis of randomized, double-blind, placebo-controlled studies. Neuropsychiatr. Dis. Treat. 12, 2859.10.2147/NDT.S117146Search in Google Scholar

Han, Y., Heuermann, R.J., Lyman, K.A., Fisher, D., Ismail, Q.-A., and Chetkovich, D.M. (2017). HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects. Mol. Psychiatry 22, 458.10.1038/mp.2016.99Search in Google Scholar

Hanslmayr, S., Staudigl, T., and Fellner, M.-C. (2012). Oscillatory power decreases and long-term memory: the information via desynchronization hypothesis. Front. Hum. Neurosci. 6, 74.10.3389/fnhum.2012.00074Search in Google Scholar

Hashimoto, K., Kakiuchi, T., Ohba, H., Nishiyama, S., and Tsukada, H. (2017). Reduction of dopamine D 2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys. Eur. Arch. Psychiatry Clin. Neurosci. 267, 173–176.10.1007/s00406-016-0692-7Search in Google Scholar

Hawksworth, C. and Serpell, M. (1998). Intrathecal anesthesia with ketamine. Reg. Anesth. Pain Med. 23, 283.Search in Google Scholar

He, H. and Richardson, J.S. (1995). A pharmacological, pharmacokinetic and clinical overview of risperidone, a new antipsychotic that blocks serotonin 5-HT₂ and dopamine D₂ receptors. Int. Clin. Psychopharmacol.10.1097/00004850-199503000-00003Search in Google Scholar

Heinke, W., Zysset, S., Hund-Georgiadis, M., Olthoff, D., and von Cramon, D.Y. (2005). The effect of esmolol on cerebral blood flow, cerebral vasoreactivity, and cognitive performance: a functional magnetic resonance imaging study. Anesthesiol. J. Am. Soc. Anesthesiol. 102, 41–50.10.1097/00000542-200501000-00010Search in Google Scholar

Heinzel, A., Steinke, R., Poeppel, T.D., Grosser, O., Bogerts, B., Otto, H., and Northoff, G. (2008). S-ketamine and GABA-A-receptor interaction in humans: an exploratory study with I-123-iomazenil SPECT. Hum. Psychopharmacol. Clin. Exp. 23, 549–554.10.1002/hup.960Search in Google Scholar

Hermes, D., Miller, K.J., Vansteensel, M.J., Aarnoutse, E.J., Leijten, F.S.S., and Ramsey, N.F. (2012). Neurophysiologic correlates of fMRI in human motor cortex. Hum. Brain Mapp. 33, 1689–1699.10.1002/hbm.21314Search in Google Scholar

Herrmann, C.S. and Knight, R.T. (2001). Mechanisms of human attention: event-related potentials and oscillations. Neurosci. Biobehav. Rev. 25, 465–476.10.1016/S0149-7634(01)00027-6Search in Google Scholar

Hevers, W., Hadley, S.H., Lüddens, H., and Amin, J. (2008). Ketamine, but not phencyclidine, selectively modulates cerebellar GABAA receptors containing α6 and δ subunits. J. Neurosci. 28, 5383–5393.10.1523/JNEUROSCI.5443-07.2008Search in Google Scholar PubMed PubMed Central

Hillebrand, A. and Barnes, G.R. (2002). A quantitative assessment of the sensitivity of whole-head MEG to activity in the adult human cortex. NeuroImage 16, 638–650.10.1006/nimg.2002.1102Search in Google Scholar PubMed

Hirota, K., Okawa, H., Appadu, B.L., Grandy, D.K., Devi, L.A., and Lambert, D.G. (1999). Stereoselective interaction of ketamine with recombinant mu, kappa, and delta opioid receptors expressed in Chinese hamster ovary cells. Anesthesiology 90, 174–182.10.1097/00000542-199901000-00023Search in Google Scholar

Hirota, K., Hashimoto, Y., and Lambert, D.G. (2002). Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in Chinese hamster ovary cells. Anesth. Analg. 95, 1607–1610.10.1097/00000539-200212000-00025Search in Google Scholar

Höflich, A., Hahn, A., Küblböck, M., Kranz, G.S., Vanicek, T., Windischberger, C., Saria, A., Kasper, S., Winkler, D., and Lanzenberger, R. (2015). Ketamine-induced modulation of the thalamo-cortical network in healthy volunteers as a model for schizophrenia. Int. J. Neuropsychopharmacol. 18, pyv040.10.1093/ijnp/pyv040Search in Google Scholar

Höflich, A., Hahn, A., Küblböck, M., Kranz, G.S., Vanicek, T., Ganger, S., Spies, M., Windischberger, C., Kasper, S., and Winkler, D. (2016). Ketamine-dependent neuronal activation in healthy volunteers. Brain Struct. Funct. 222, 1–10.10.1007/s00429-016-1291-0Search in Google Scholar

Hoge, R.D., Atkinson, J., Gill, B., Crelier, G.R., Marrett, S., and Pike, G.B. (1999). Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc. Natl. Acad. Sci. 96, 9403–9408.10.1073/pnas.96.16.9403Search in Google Scholar

Holcomb, H.H., Lahti, A.C., Medoff, D.R., Weiler, M., and Tamminga, C.A. (2001). Sequential regional cerebral blood flow brain scans using PET with H 2 15 O demonstrate ketamine actions in CNS dynamically. Neuropsychopharmacology 25, 165.10.1016/S0893-133X(01)00229-9Search in Google Scholar

Homayoun, H. and Moghaddam, B. (2007). NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J. Neurosci. 27, 11496–11500.10.1523/JNEUROSCI.2213-07.2007Search in Google Scholar PubMed PubMed Central

Hong, L.E., Summerfelt, A., Buchanan, R.W., O’donnell, P., Thaker, G.K., Weiler, M.A., and Lahti, A.C. (2010). Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine. Neuropsychopharmacology 35, 632.10.1038/npp.2009.168Search in Google Scholar PubMed PubMed Central

Horacek, J., Brunovsky, M., Novak, T., Tislerova, B., Palenicek, T., Bubenikova-Valesova, V., Spaniel, F., Koprivova, J., Mohr, P., and Balikova, M. (2010). Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect. Psychol. Med. 40, 1443–1451.10.1017/S0033291709991619Search in Google Scholar PubMed

Hughes, S.W. and Crunelli, V. (2005). Thalamic mechanisms of EEG alpha rhythms and their pathological implications. The Neuroscientist 11, 357–372.10.1177/1073858405277450Search in Google Scholar PubMed

Hughes, S.W., Lörincz, M., Cope, D.W., Blethyn, K.L., Kékesi, K.A., Parri, H.R., Juhász, G., and Crunelli, V. (2004). Synchronized oscillations at α and θ frequencies in the lateral geniculate nucleus. Neuron 42, 253–268.10.1016/S0896-6273(04)00191-6Search in Google Scholar

Hunt, M.J. and Kasicki, S. (2013). A systematic review of the effects of NMDA receptor antagonists on oscillatory activity recorded in vivo. J. Psychopharmacol. (Oxf.) 27, 972–986.10.1177/0269881113495117Search in Google Scholar

Hunt, M.J., Raynaud, B., and Garcia, R. (2006). Ketamine dose-dependently induces high-frequency oscillations in the nucleus accumbens in freely moving rats. Biol. Psychiatry 60, 1206–1214.10.1016/j.biopsych.2006.01.020Search in Google Scholar

Hunt, M.J., Falinska, M., Łęski, S., Wójcik, D.K., and Kasicki, S. (2011). Differential effects produced by ketamine on oscillatory activity recorded in the rat hippocampus, dorsal striatum and nucleus accumbens. J. Psychopharmacol. (Oxf.) 25, 808–821.10.1177/0269881110362126Search in Google Scholar

Hunt, M.J., Adams, N.E., Średniawa, W., Wójcik, D.K., Simon, A., Kasicki, S., and Whittington, M.A. (2018). The olfactory bulb is a source of high-frequency oscillations (130–180 Hz) associated with a subanesthetic dose of ketamine in rodents. Neuropsychopharmacology 44, 435–442.10.1038/s41386-018-0173-ySearch in Google Scholar

Hustveit, O., Maurset, A., and Øye, I. (1995). Interaction of the chiral forms of ketamine with opioid, phencyclidine, σ and muscarinic receptors. Basic Clin. Pharmacol. Toxicol. 77, 355–359.10.1111/j.1600-0773.1995.tb01041.xSearch in Google Scholar

Idvall, J., Ahlgren, I., Aronsen, K.F., and Stenberg, P. (1979). Ketamine infusions: pharmacokinetics and clinical effects. Br. J. Anaesth. 51, 1167–1173.10.1097/00132586-198012000-00039Search in Google Scholar

Ihmsen, H., Geisslinger, G., and Schüttler, J. (2001). Stereoselective pharmacokinetics of ketamine: R (−)-ketamine inhibits the elimination of S (+)-ketamine. Clin. Pharmacol. Ther. 70, 431–438.10.1067/mcp.2001.119722Search in Google Scholar

Irifune, M., Shimizu, T., Nomoto, M., and Fukuda, T. (1992). Ketamine-induced anesthesia involves the N-methyl-D-aspartate receptor-channel complex in mice. Brain Res. 596, 1–9.10.1016/0006-8993(92)91525-JSearch in Google Scholar

Jansen, K.L. (2001). Ketamine: Dreams and Realities (Sarasota, FL USA: Multidisciplinary Association for Psychedelic Studies).Search in Google Scholar

Jasper, H. and Penfield, W. (1949). Electrocorticograms in man: effect of voluntary movement upon the electrical activity of the precentral gyrus. Arch. Für Psychiatr. Nervenkrankh. 183, 163–174.10.1007/BF01062488Search in Google Scholar

Javitt, D.C., Carter, C.S., Krystal, J.H., Kantrowitz, J.T., Girgis, R.R., Kegeles, L.S., Ragland, J.D., Maddock, R.J., Lesh, T.A., and Tanase, C. (2018). Utility of imaging-based biomarkers for glutamate-targeted drug development in psychotic disorders: a randomized clinical trial. JAMA Psychiatry 75, 11–19.10.1001/jamapsychiatry.2017.3572Search in Google Scholar PubMed PubMed Central

Jing, W., Wang, Y., Fang, G., Chen, M., Xue, M., Guo, D., Yao, D., and Xia, Y. (2016). EEG bands of wakeful rest, slow-wave and rapid-eye-movement sleep at different brain areas in rats. Front. Comput. Neurosci. 10, 79.10.3389/fncom.2016.00079Search in Google Scholar PubMed PubMed Central

Jones, N.C., Reddy, M., Anderson, P., Salzberg, M.R., O’Brien, T.J., and Pinault, D. (2012). Acute administration of typical and atypical antipsychotics reduces EEG gamma power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in gamma power. Int. J. Neuropsychopharmacol. 15, 657–668.10.1017/S1461145711000848Search in Google Scholar PubMed PubMed Central

Joules, R., Doyle, O.M., Schwarz, A.J., O’Daly, O.G., Brammer, M., Williams, S.C., and Mehta, M.A. (2015). Ketamine induces a robust whole-brain connectivity pattern that can be differentially modulated by drugs of different mechanism and clinical profile. Psychopharmacology (Berl.) 232, 4205–4218.10.1007/s00213-015-3951-9Search in Google Scholar PubMed PubMed Central

Kane, N., Acharya, J., Benickzy, S., Caboclo, L., Finnigan, S., Kaplan, P.W., Shibasaki, H., Pressler, R., and van Putten, M.J. (2017). A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017. Clin. Neurophysiol. Pract. 2, 170–185.10.1016/j.cnp.2017.07.002Search in Google Scholar PubMed PubMed Central

Kapur, S. and Seeman, P. (2002). NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D2 and serotonin 5-HT2receptors – implications for models of schizophrenia. Mol. Psychiatry 7, 837.10.1038/sj.mp.4001093Search in Google Scholar PubMed

Katzner, S., Nauhaus, I., Benucci, A., Bonin, V., Ringach, D.L., and Carandini, M. (2009). Local origin of field potentials in visual cortex. Neuron 61, 35–41.10.1016/j.neuron.2008.11.016Search in Google Scholar PubMed PubMed Central

Kegeles, L.S., Mao, X., Ojeil, N., Massuda, R., Pedrini, M., Chen, C.-M., Slifstein, M., Abi-Dargham, A., Milak, M., and Shungu, D.C. (2013). J-editing/MEGA-PRESS time-course study of the neurochemical effects of ketamine administration in healthy humans. p. 1206.Search in Google Scholar

Khalili-Mahani, N., Niesters, M., van Osch, M.J., Oitzl, M., Veer, I., de Rooij, M., van Gerven, J., van Buchem, M.A., Beckmann, C.F., and Rombouts, S.A. (2015). Ketamine interactions with biomarkers of stress: a randomized placebo-controlled repeated measures resting-state fMRI and PCASL pilot study in healthy men. Neuroimage 108, 396–409.10.1016/j.neuroimage.2014.12.050Search in Google Scholar PubMed

Kim, S.H., Price, M.T., Olney, J.W., and Farber, N.B. (1999). Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and α 2-adrenergic agonists. Mol. Psychiatry 4, 344.10.1038/sj.mp.4000529Search in Google Scholar PubMed

Kittelberger, K., Hur, E.E., Sazegar, S., Keshavan, V., and Kocsis, B. (2012). Comparison of the effects of acute and chronic administration of ketamine on hippocampal oscillations: relevance for the NMDA receptor hypofunction model of schizophrenia. Brain Struct. Funct. 217, 395–409.10.1007/s00429-011-0351-8Search in Google Scholar PubMed PubMed Central

Knott, V., McIntosh, J., Millar, A., Fisher, D., Villeneuve, C., Ilivitsky, V., and Horn, E. (2006). Nicotine and smoker status moderate brain electric and mood activation induced by ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist. Pharmacol. Biochem. Behav. 85, 228–242.10.1016/j.pbb.2006.08.005Search in Google Scholar

Knyazev, G.G. (2012). EEG delta oscillations as a correlate of basic homeostatic and motivational processes. Neurosci. Biobehav. Rev. 36, 677–695.10.1016/j.neubiorev.2011.10.002Search in Google Scholar

Kochs, E., Scharein, E., Mollenberg, O., Bromm, B., and am Esch, J.S. (1996). Analgesic efficacy of low-dose ketamine. Somatosensory-evoked responses in relation to subjective pain ratings. J. Am. Soc. Anesthesiol. 85, 304–314.10.1097/00000542-199608000-00012Search in Google Scholar

Kocsis, B. (2012). Differential role of NR2A and NR2B subunits in N-methyl-D-aspartate receptor antagonist-induced aberrant cortical gamma oscillations. Biol. Psychiatry 71, 987–995.10.1016/j.biopsych.2011.10.002Search in Google Scholar

Kohrs, R. and Durieux, M.E. (1998). Ketamine: teaching an old drug new tricks. Anesth. Analg. 87, 1186–1193.Search in Google Scholar

Konradsson, Å., Marcus, M.M., Hertel, P., Svensson, T.H., and Jardemark, K.E. (2006). Inhibition of the glycine transporter GlyT-1 potentiates the effect of risperidone, but not clozapine, on glutamatergic transmission in the rat medial prefrontal cortex. Synapse 60, 102–108.10.1002/syn.20286Search in Google Scholar

Kontos, H.A., Wei, E.P., Navari, R.M., Levasseur, J.E., Rosenblum, W.I., and Patterson, J.L. (1978). Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am. J. Physiol.-Heart Circ. Physiol. 234, H371–H383.10.1152/ajpheart.1978.234.4.H371Search in Google Scholar

Kopell, N., Whittington, M.A., and Kramer, M.A. (2011). Neuronal assembly dynamics in the beta1 frequency range permits short-term memory. Proc. Natl. Acad. Sci. 201019676.10.1073/pnas.1019676108Search in Google Scholar

Kornhuber, J., Mack-Burkhardt, F., Kornhuber, M.E., and Riederer, P. (1989). [3H]MK-801 binding sites in post-mortem human frontal cortex. Eur. J. Pharmacol. 162, 483–490.10.1016/0014-2999(89)90339-7Search in Google Scholar

Kortekaas, R., Maguire, R.P., van Waarde, A., Leenders, K.L., and Elsinga, P.H. (2008). Despite irreversible binding, PET tracer [11C]-SA5845 is suitable for imaging of drug competition at sigma receptors – the cases of ketamine and haloperidol. Neurochem. Int. 53, 45–50.10.1016/j.neuint.2008.04.010Search in Google Scholar PubMed

Kraguljac, N.V., Frölich, M.A., Tran, S., White, D.M., Nichols, N., Barton-McArdle, A., Reid, M.A., Bolding, M.S., and Lahti, A.C. (2017). Ketamine modulates hippocampal neurochemistry and functional connectivity: a combined magnetic resonance spectroscopy and resting-state fMRI study in healthy volunteers. Mol. Psychiatry.10.1038/mp.2016.122Search in Google Scholar PubMed PubMed Central

Krystal, J.H., Karper, L.P., Seibyl, J.P., Freeman, G.K., Delaney, R., Bremner, J.D., Heninger, G.R., Bowers, M.B., and Charney, D.S. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 51, 199–214.10.1001/archpsyc.1994.03950030035004Search in Google Scholar

Kulikova, S.P., Tolmacheva, E.A., Anderson, P., Gaudias, J., Adams, B.E., Zheng, T., and Pinault, D. (2012). Opposite effects of ketamine and deep brain stimulation on rat thalamocortical information processing. Eur. J. Neurosci. 36, 3407–3419.10.1111/j.1460-9568.2012.08263.xSearch in Google Scholar

Lally, N., Nugent, A.C., Luckenbaugh, D.A., Niciu, M.J., Roiser, J.P., and Zarate, C.A. (2015). Neural correlates of change in major depressive disorder anhedonia following open-label ketamine. J. Psychopharmacol. (Oxf.) 29, 596–607.10.1177/0269881114568041Search in Google Scholar

Lang, E.W., Dieh, R.R., Timmermann, L., Baron, R., Deusch, G., Mehdorn, H.M., and Zunker, P. (1999). Spontaneous oscillations of arterial blood pressure, cerebral and peripheral blood flow in healthy and comatose subjects. Neurol. Res. 21, 665–669.10.1080/01616412.1999.11740995Search in Google Scholar

Långsjö, J.W., Kaisti, K.K., Aalto, S., Hinkka, S., Aantaa, R., Oikonen, V., Sipilä, H., Kurki, T., Silvanto, M., and Scheinin, H. (2003). Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiol. J. Am. Soc. Anesthesiol. 99, 614–623.10.1097/00000542-200309000-00016Search in Google Scholar

Långsjö, J.W., Salmi, E., Kaisti, K.K., Aalto, S., Hinkka, S., Aantaa, R., Oikonen, V., Viljanen, T., Kurki, T., and Silvanto, M. (2004). Effects of subanesthetic ketamine on regional cerebral glucose metabolism in humans. J. Am. Soc. Anesthesiol. 100, 1065–1071.10.1097/00000542-200405000-00006Search in Google Scholar

Långsjö, J.W., Maksimow, A., Salmi, E., Kaisti, K., Aalto, S., Oikonen, V., Hinkka, S., Aantaa, R., Sipilä, H., and Viljanen, T. (2005). S-ketamine anesthesia increases cerebral blood flow in excess of the metabolic needs in humans. J. Am. Soc. Anesthesiol. 103, 258–268.10.1097/00000542-200508000-00008Search in Google Scholar

Laufs, H., Kleinschmidt, A., Beyerle, A., Eger, E., Salek-Haddadi, A., Preibisch, C., and Krakow, K. (2003). EEG-correlated fMRI of human alpha activity. NeuroImage 19, 1463–1476.10.1016/S1053-8119(03)00286-6Search in Google Scholar

Lazarewicz, M.T., Ehrlichman, R.S., Maxwell, C.R., Gandal, M.J., Finkel, L.H., and Siegel, S.J. (2010). Ketamine modulates theta and gamma oscillations. J. Cogn. Neurosci. 22, 1452–1464.10.1162/jocn.2009.21305Search in Google Scholar PubMed

Lee, H., Mashour, G.A., Noh, G.-J., Kim, S., and Lee, U. (2013a). Reconfiguration of network hub structure after propofol-induced unconsciousness. Anesthesiol. J. Am. Soc. Anesthesiol. 119, 1347–1359.10.1097/ALN.0b013e3182a8ec8cSearch in Google Scholar PubMed PubMed Central

Lee, U., Ku, S., Noh, G., Baek, S., Choi, B., and Mashour, G.A. (2013b). Disruption of frontal–parietal communication by ketamine, propofol, and sevoflurane. J. Am. Soc. Anesthesiol. 118, 1264–1275.10.1097/ALN.0b013e31829103f5Search in Google Scholar

Lepack, A.E., Fuchikami, M., Dwyer, J.M., Banasr, M., and Duman, R.S. (2015). BDNF release is required for the behavioral actions of ketamine. Int. J. Neuropsychopharmacol. 18, pyu033.10.1093/ijnp/pyu033Search in Google Scholar

Li, D. and Mashour, G.A. (2019). Cortical dynamics during psychedelic and anesthetized states induced by ketamine. NeuroImage 196, 32–40.10.1016/j.neuroimage.2019.03.076Search in Google Scholar

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J.M., Iwata, M., Li, X.-Y., Aghajanian, G., and Duman, R.S. (2010). mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329, 959–964.10.1126/science.1190287Search in Google Scholar

Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C., Schulz, D., Henn, F., and Malinow, R. (2011). Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature 470, 535–539.10.1038/nature09742Search in Google Scholar

Lilburn, J.K., Dundee, J.W., Nair, S.G., Fee, J.P.H., and Johnston, H.M.L. (1978). Ketamine sequelae: evaluation of the ability of various premedicants to attenuate its psychic actions. Anaesthesia 33, 307–311.10.1111/j.1365-2044.1978.tb12412.xSearch in Google Scholar

Lilius, T., Kangas, E., Niemi, M., Rauhala, P., and Kalso, E. (2018). Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability. Br. J. Anaesth. 120, 818–826.10.1016/j.bja.2017.11.081Search in Google Scholar

Little, B., Chang, T., Chucot, L., Dill, W.A., Enrile, L.L., Glazko, A.J., Jassani, M., Kretchmer, H., and Sweet, A.Y. (1972). Study of ketamine as an obstetric anesthetic agent. Am. J. Obstet. Gynecol. 113, 247–260.10.1016/0002-9378(72)90774-0Search in Google Scholar

Littlewood, C.L., Jones, N., O’Neill, M.J., Mitchell, S.N., Tricklebank, M., and Williams, S.C. (2006). Mapping the central effects of ketamine in the rat using pharmacological MRI. Psychopharmacology (Berl.) 186, 64–81.10.1007/s00213-006-0344-0Search in Google Scholar PubMed

Llamosas, N., Perez-Caballero, L., Berrocoso, E., Bruzos-Cidon, C., Ugedo, L., and Torrecilla, M. (2018). Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus. Prog. Neuropsychopharmacol. Biol. Psychiatry. 88, 243–25210.1016/j.pnpbp.2018.07.022Search in Google Scholar PubMed

Logothetis, N.K. (2008). What we can do and what we cannot do with fMRI. Nature 453, 869–878.10.1038/nature06976Search in Google Scholar

Logothetis, N.K., Pauls, J., Augath, M., Trinath, T., and Oeltermann, A. (2001). Neurophysiological investigation of the basis of the fMRI signal. Nature 412, 150–157.10.1038/35084005Search in Google Scholar

Lukashevich, I.P. and Sazonova, O.B. (1996). The effect of lesions of different parts of the optic thalamus on the nature of the bioelectrical activity of the human brain. Zhurnal Vysshei Nervn. Deiatelnosti Im. IP Pavlova 46, 866–874.Search in Google Scholar

Ma, J. and Leung, L.S. (2007). The supramammillo–septal–hippocampal pathway mediates sensorimotor gating impairment and hyperlocomotion induced by MK-801 and ketamine in rats. Psychopharmacology (Berl.) 191, 961–974.10.1007/s00213-006-0667-xSearch in Google Scholar

Maeng, S., Zarate, C.A., Du, J., Schloesser, R.J., McCammon, J., Chen, G., and Manji, H.K. (2008). Cellular mechanisms underlying the antidepressant effects of ketamine: role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol. Psychiatry 63, 349–352.10.1016/j.biopsych.2007.05.028Search in Google Scholar

Maltbie, E., Gopinath, K., Urushino, N., Kempf, D., and Howell, L. (2016). Ketamine-induced brain activation in awake female nonhuman primates: a translational functional imaging model. Psychopharmacology (Berl.) 233, 961–972.10.1007/s00213-015-4175-8Search in Google Scholar

Maltbie, E.A., Kaundinya, G.S., and Howell, L.L. (2017). Ketamine and pharmacological imaging: use of functional magnetic resonance imaging to evaluate mechanisms of action. Behav. Pharmacol. 28, 610–622.10.1097/FBP.0000000000000354Search in Google Scholar

Mantere, T., Tupala, E., Hall, H., Särkioja, T., Räsänen, P., Bergström, K., Callaway, J., and Tiihonen, J. (2002). Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study. Am. J. Psychiatry 159, 599–606.10.1176/appi.ajp.159.4.599Search in Google Scholar

Martin, W.R., Eades, C.G., Thompson, J.A., Huppler, R.E., and Gilbert, P.E. (1976). The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197, 517–532.Search in Google Scholar

Mattia, A. and Moreton, J.E. (1986). Electroencephalographic (EEG), EEG power spectra, and behavioral correlates in rats given phencyclidine. Neuropharmacology 25, 763–769.10.1016/0028-3908(86)90093-6Search in Google Scholar

Mayberg, H.S., Liotti, M., Brannan, S.K., McGinnis, S., Mahurin, R.K., Jerabek, P.A., Silva, J.A., Tekell, J.L., Martin, C.C., Lancaster, J.L., et al. (1999). Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am. J. Psychiatry 156, 675–682.Search in Google Scholar

McGirr, A., Berlim, M.T., Bond, D.J., Fleck, M.P., Yatham, L.N., and Lam, R.W. (2015). A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes. Psychol. Med. 45, 693–704.10.1017/S0033291714001603Search in Google Scholar PubMed

McMillan, R., Forsyth, A., Campbell, D., Malpas, G., Maxwell, E., Dukart, J., Hipp, J., and Muthukumaraswamy, S. (2019). Temporal dynamics of the pharmacological MRI response to subanaesthetic ketamine in healthy volunteers: a simultaneous EEG/fMRI study. J. Psychopharmacol. (Oxf.) 33, 219–229.10.1177/0269881118822263Search in Google Scholar PubMed

Meng, L., Hou, W., Chui, J., Han, R., and Gelb, A.W. (2015). Cardiac output and cerebral blood flow: the integrated regulation of brain perfusion in adult humans. Anesthesiol. J. Am. Soc. Anesthesiol. 123, 1198–1208.10.1097/ALN.0000000000000872Search in Google Scholar PubMed

Mikkelsen, S., Ilkjaer, S., Brennum, J., Borgbjerg, F.M., and Dahl, J.B. (1999). The effect of naloxone on ketamine-induced effects on hyperalgesia and ketamine-induced side effects in humans. Anesthesiol. J. Am. Soc. Anesthesiol. 90, 1539–1545.10.1097/00000542-199906000-00007Search in Google Scholar PubMed

Mineur, Y.S. and Picciotto, M.R. (2010). Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends Pharmacol. Sci. 31, 580–586.10.1016/j.tips.2010.09.004Search in Google Scholar PubMed PubMed Central

Moaddel, R., Venkata, S.L.V., Tanga, M.J., Bupp, J.E., Green, C.E., Iyer, L., Furimsky, A., Goldberg, M.E., Torjman, M.C., and Wainer, I.W. (2010). A parallel chiral–achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome. Talanta 82, 1892–1904.10.1016/j.talanta.2010.08.005Search in Google Scholar PubMed PubMed Central

Moaddel, R., Abdrakhmanova, G., Kozak, J., Jozwiak, K., Toll, L., Jimenez, L., Rosenberg, A., Tran, T., Xiao, Y., and Zarate, C.A. (2013). Sub-anesthetic concentrations of (R, S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors. Eur. J. Pharmacol. 698, 228–234.10.1016/j.ejphar.2012.11.023Search in Google Scholar PubMed PubMed Central

Moghaddam, B. and Adams, B.W. (1998). Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281, 1349–1352.10.1126/science.281.5381.1349Search in Google Scholar PubMed

Moghaddam, B., Adams, B., Verma, A., and Daly, D. (1997). Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17, 2921–2927.10.1523/JNEUROSCI.17-08-02921.1997Search in Google Scholar

Moran, R.J., Jones, M.W., Blockeel, A.J., Adams, R.A., Stephan, K.E., and Friston, K.J. (2015). Losing control under ketamine: suppressed cortico-hippocampal drive following acute ketamine in rats. Neuropsychopharmacology 40, 268.10.1038/npp.2014.184Search in Google Scholar PubMed PubMed Central

Morgan, C.J.A. and Curran, H.V. (2006). Acute and chronic effects of ketamine upon human memory: a review. Psychopharmacology (Berl.) 188, 408–424.10.1007/s00213-006-0572-3Search in Google Scholar PubMed

Mueller, F., Musso, F., London, M., de Boer, P., Zacharias, N., and Winterer, G. (2018). Pharmacological fMRI: effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network. NeuroImage Clin. 17, 745–757.10.1016/j.nicl.2018.05.037Search in Google Scholar PubMed PubMed Central

Murakami, S. and Okada, Y. (2006). Contributions of principal neocortical neurons to magnetoencephalography and electroencephalography signals. J. Physiol. 575, 925–936.10.1113/jphysiol.2006.105379Search in Google Scholar PubMed PubMed Central

Murphy, K., Harris, A.D., and Wise, R.G. (2011). Robustly measuring vascular reactivity differences with breath-hold: normalising stimulus-evoked and resting state BOLD fMRI data. Neuroimage 54, 369–379.10.1016/j.neuroimage.2010.07.059Search in Google Scholar PubMed

Murphy, K., Birn, R.M., and Bandettini, P.A. (2013). Resting-state fMRI confounds and cleanup. Neuroimage 80, 349–359.10.1016/j.neuroimage.2013.04.001Search in Google Scholar PubMed PubMed Central

Murrough, J.W., Perez, A.M., Pillemer, S., Stern, J., Parides, M.K., aan het Rot, M., Collins, K.A., Mathew, S.J., Charney, D.S., and Iosifescu, D.V. (2013a). Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol. Psychiatry 74, 250–256.10.1016/j.biopsych.2012.06.022Search in Google Scholar PubMed PubMed Central

Murrough, J.W., Iosifescu, D.V., Chang, L.C., Al Jurdi, R.K., Green, C.E., Perez, A.M., Iqbal, S., Pillemer, S., Foulkes, A., and Shah, A. (2013b). Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am. J. Psychiatry 170, 1134–1142.10.1176/appi.ajp.2013.13030392Search in Google Scholar PubMed PubMed Central

Murrough, J.W., Abdallah, C.G., Anticevic, A., Collins, K.A., Geha, P., Averill, L.A., Schwartz, J., DeWilde, K.E., Averill, C., and Jia-Wei Yang, G. (2016). Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder. Hum. Brain Mapp. 37, 3214–3223.10.1002/hbm.23235Search in Google Scholar PubMed PubMed Central

Muthukumaraswamy, S.D. (2014). The use of magnetoencephalography in the study of psychopharmacology (pharmaco-MEG). J. Psychopharmacol. (Oxf.) 28, 815–829.10.1177/0269881114536790Search in Google Scholar PubMed

Muthukumaraswamy, S.D. and Liley, D.T. (2018). 1/f electrophysiological spectra in resting and drug-induced states can be explained by the dynamics of multiple oscillatory relaxation processes. Neuroimage 179, 582–595.10.1016/j.neuroimage.2018.06.068Search in Google Scholar PubMed

Muthukumaraswamy, S.D. and Singh, K.D. (2009). Functional decoupling of BOLD and gamma-band amplitudes in human primary visual cortex. Hum. Brain Mapp. 30, 2000–2007.10.1002/hbm.20644Search in Google Scholar PubMed PubMed Central

Muthukumaraswamy, S.D., Shaw, A.D., Jackson, L.E., Hall, J., Moran, R., and Saxena, N. (2015). Evidence that subanesthetic doses of ketamine cause sustained disruptions of NMDA and AMPA-mediated frontoparietal connectivity in humans. J. Neurosci. 35, 11694–11706.10.1523/JNEUROSCI.0903-15.2015Search in Google Scholar PubMed PubMed Central

Naughton, M., Clarke, G., O′Leary, O.F., Cryan, J.F., and Dinan, T.G. (2014). A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action. J. Affect. Disord. 156, 24–35.10.1016/j.jad.2013.11.014Search in Google Scholar PubMed

Nauhaus, I., Busse, L., Carandini, M., and Ringach, D.L. (2009). Stimulus contrast modulates functional connectivity in visual cortex. Nat. Neurosci. 12, 70–76.10.1038/nn.2232Search in Google Scholar PubMed PubMed Central

Nelson, C.L., Burk, J.A., Bruno, J.P., and Sarter, M. (2002). Effects of acute and repeated systemic administration of ketamine on prefrontal acetylcholine release and sustained attention performance in rats. Psychopharmacology (Berl.) 161, 168–179.10.1007/s00213-002-1004-7Search in Google Scholar PubMed

Newport, D.J., Carpenter, L.L., McDonald, W.M., Potash, J.B., Tohen, M., and Nemeroff, C.B. (2015). Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression. Am. J. Psychiatry 172, 950–966.10.1176/appi.ajp.2015.15040465Search in Google Scholar PubMed

Niedermeyer, E. and da Silva, F.L. (2005). Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (Philadelphia: Lippincott Williams & Wilkins).Search in Google Scholar

Niessing, J. (2005). Hemodynamic signals correlate tightly with synchronized gamma oscillations. Science 309, 948–951.10.1126/science.1110948Search in Google Scholar PubMed

Niesters, M., Khalili-Mahani, N., Martini, C., Aarts, L., van Gerven, J., van Buchem, M.A., Dahan, A., and Rombouts, S. (2012). Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers. Anesthesiol. J. Am. Soc. Anesthesiol. 117, 868–877.10.1097/ALN.0b013e31826a0db3Search in Google Scholar PubMed

Nishimura, M., Sato, K., Okada, T., Yoshiya, I., Schloss, P., Shimada, S., and Tohyama, M. (1998). Ketamine inhibits monoamine transporters expressed in human embryonic kidney 293 cells. Anesthesiol. J. Am. Soc. Anesthesiol. 88, 768–774.10.1097/00000542-199803000-00029Search in Google Scholar PubMed

Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Shirakawa, H., Nakagawa, T., and Kaneko, S. (2014). Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex. Int. J. Neuropsychopharmacol. 17, 1321–1326.10.1017/S1461145714000649Search in Google Scholar PubMed

Nugent, A.C., Robinson, S.E., Coppola, R., Furey, M.L., and Zarate, C.A. (2015). Group differences in MEG-ICA derived resting state networks: application to major depressive disorder. NeuroImage 118, 1–12.10.1016/j.neuroimage.2015.05.051Search in Google Scholar PubMed PubMed Central

Nugent, A.C., Robinson, S.E., Coppola, R., and Zarate, C.A. (2016). Preliminary differences in resting state MEG functional connectivity pre- and post-ketamine in major depressive disorder. Psychiatry Res. Neuroimaging 254, 56–66.10.1016/j.pscychresns.2016.06.006Search in Google Scholar PubMed PubMed Central

Nugent, A.C., Ballard, E.D., Gould, T.D., Park, L.T., Moaddel, R., Brutsche, N.E., and Zarate, C.A. (2018). Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects. Mol. Psychiatry 24, 1040–1052.10.1038/s41380-018-0028-2Search in Google Scholar

Nunez, P.L. and Cutillo, B.A. (1995). Neocortical Dynamics and Human EEG Rhythms (New York: Oxford University Press).Search in Google Scholar

Nunez, P.L., Silberstein, R.B., Cadusch, P.J., Wijesinghe, R.S., Westdorp, A.F., and Srinivasan, R. (1994). A theoretical and experimental study of high resolution EEG based on surface Laplacians and cortical imaging. Electroencephalogr. Clin. Neurophysiol. 90, 40–57.10.1016/0013-4694(94)90112-0Search in Google Scholar

Nyberg, S., Eriksson, B., Oxenstierna, G., Halldin, C., and Farde, L. (1999). Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. Am. J. Psychiatry 156, 869–875.10.1176/ajp.156.6.869Search in Google Scholar PubMed

Olney, J.W., Labruyere, J., and Price, M.T. (1989). Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244, 1360–1362.10.1126/science.2660263Search in Google Scholar PubMed

Olney, J.W., Labruyere, J., Wang, G., Wozniak, D.F., Price, M.T., and Sesma, M.A. (1991). NMDA antagonist neurotoxicity: mechanism and prevention. Science 254, 1515–1518.10.1126/science.1835799Search in Google Scholar PubMed

Orser, B.A., Pennefather, P.S., and MacDonald, J.F. (1997). Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiol. J. Am. Soc. Anesthesiol. 86, 903–917.10.1097/00000542-199704000-00021Search in Google Scholar PubMed

Pal, D., Hambrecht-Wiedbusch, V.S., Silverstein, B.H., and Mashour, G.A. (2015). Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness. BJA Br. J. Anaesth. 114, 979–989.10.1093/bja/aev095Search in Google Scholar PubMed PubMed Central

Pal, D., Silverstein, B.H., Sharba, L., Li, D., Hambrecht-Wiedbusch, V.S., Hudetz, A.G., and Mashour, G.A. (2017). Propofol, sevoflurane, and ketamine induce a reversible increase in delta-gamma and theta-gamma phase-amplitude coupling in frontal cortex of rat. Front. Syst. Neurosci. 11, 41.10.3389/fnsys.2017.00041Search in Google Scholar PubMed PubMed Central

Páleníček, T., Fujáková, M., Brunovský, M., Balíková, M., Horáček, J., Gorman, I., Tylš, F., Tišlerová, B., Šoš, P., and Bubeníková-Valešová, V. (2011). Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics. Neuropsychobiology 63, 202–218.10.1159/000321803Search in Google Scholar PubMed

Palva, S. and Palva, J.M. (2007). New vistas for α-frequency band oscillations. Trends Neurosci. 30, 150–158.10.1016/j.tins.2007.02.001Search in Google Scholar PubMed

Park, H.-J. and Friston, K. (2013). Structural and functional brain networks: from connections to cognition. Science 342, 1238411.10.1126/science.1238411Search in Google Scholar PubMed

Pauling, L. and Coryell, C.D. (1936). The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin. Proc. Natl. Acad. Sci. 22, 210–216.10.1073/pnas.22.4.210Search in Google Scholar PubMed PubMed Central

Peltoniemi, M.A., Saari, T.I., Hagelberg, N.M., Laine, K., Kurkinen, K.J., Neuvonen, P.J., and Olkkola, K.T. (2012). Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine. Basic Clin. Pharmacol. Toxicol. 111, 325–332.10.1111/j.1742-7843.2012.00908.xSearch in Google Scholar PubMed

Peltoniemi, M.A., Hagelberg, N.M., Olkkola, K.T., and Saari, T.I. (2016). Ketamine: a review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy. Clin. Pharmacokinet. 55, 1059–1077.10.1007/s40262-016-0383-6Search in Google Scholar PubMed

Penttonen, M. and Buzsáki, G. (2003). Natural logarithmic relationship between brain oscillators. Thalamus Relat. Syst. 2, 145–152.10.1017/S1472928803000074Search in Google Scholar

Pesonen, M., Hämäläinen, H., and Krause, C.M. (2007). Brain oscillatory 4–30 Hz responses during a visual n-back memory task with varying memory load. Brain Res. 1138, 171–177.10.1016/j.brainres.2006.12.076Search in Google Scholar PubMed

Phelps, M.E. (2000). Positron emission tomography provides molecular imaging of biological processes. Proc. Natl. Acad. Sci. 97, 9226–9233.10.1073/pnas.97.16.9226Search in Google Scholar PubMed PubMed Central

Phillips, K.G., Cotel, M.C., McCarthy, A.P., Edgar, D.M., Tricklebank, M., O’Neill, M.J., Jones, M.W., and Wafford, K.A. (2012). Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia. Neuropharmacology 62, 1359–1370.10.1016/j.neuropharm.2011.04.006Search in Google Scholar PubMed

Piai, V., Roelofs, A., Rommers, J., and Maris, E. (2015). Beta oscillations reflect memory and motor aspects of spoken word production. Hum. Brain Mapp. 36, 2767–2780.10.1002/hbm.22806Search in Google Scholar PubMed PubMed Central

Pinault, D. (2008). N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant γ oscillations in the rat neocortex. Biol. Psychiatry 63, 730–735.10.1016/j.biopsych.2007.10.006Search in Google Scholar PubMed

Plonsey, R. and Barr, R. (2007). Bioelectricity: A Quantitative Approach (New York, NY: Springer).Search in Google Scholar

Polis, A.J., Fitzgerald, P.J., Hale, P.J., and Watson, B.O. (2019). Rodent ketamine depression-related research: finding patterns in a literature of variability. Behav. Brain Res. 376, 112153.10.1016/j.bbr.2019.112153Search in Google Scholar PubMed PubMed Central

Pollak, T.A., De Simoni, S., Barimani, B., Zelaya, F.O., Stone, J.M., and Mehta, M.A. (2015). Phenomenologically distinct psychotomimetic effects of ketamine are associated with cerebral blood flow changes in functionally relevant cerebral foci: a continuous arterial spin labelling study. Psychopharmacology (Berl.) 232, 4515–4524.10.1007/s00213-015-4078-8Search in Google Scholar PubMed

Portmann, S., Kwan, H.Y., Theurillat, R., Schmitz, A., Mevissen, M., and Thormann, W. (2010). Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro. J. Chromatogr. A 1217, 7942–7948.10.1016/j.chroma.2010.06.028Search in Google Scholar PubMed

Power, J.D., Cohen, A.L., Nelson, S.M., Wig, G.S., Barnes, K.A., Church, J.A., Vogel, A.C., Laumann, T.O., Miezin, F.M., and Schlaggar, B.L. (2011). Functional network organization of the human brain. Neuron 72, 665–678.10.1016/j.neuron.2011.09.006Search in Google Scholar PubMed PubMed Central

Power, J.D., Plitt, M., Laumann, T.O., and Martin, A. (2017). Sources and implications of whole-brain fMRI signals in humans. NeuroImage 146, 609–625.10.1016/j.neuroimage.2016.09.038Search in Google Scholar PubMed PubMed Central

Raichle, M.E. and Stone, H.L. (1971). Cerebral blood flow autoregulation and graded hypercapnia. Eur. Neurol. 6, 1–5.10.1159/000114443Search in Google Scholar PubMed

Ramadan, S., Lin, A., and Stanwell, P. (2013). Glutamate and glutamine: a review of in vivo MRS in the human brain. NMR Biomed. 26, 1630–1646.10.1002/nbm.3045Search in Google Scholar PubMed PubMed Central

Rao, J.-S., Liu, Z., Zhao, C., Wei, R.-H., Zhao, W., Tian, P.-Y., Zhou, X., Yang, Z.-Y., and Li, X.-G. (2017). Ketamine changes the local resting-state functional properties of anesthetized-monkey brain. Magn. Reson. Imaging 43, 144–150.10.1016/j.mri.2017.07.025Search in Google Scholar PubMed

Richerson, S., Ingram, M., Perry, D., and Stecker, M.M. (2005). Classification of the extracellular fields produced by activated neural structures. Biomed. Eng. OnLine 4, 1–23.10.1186/1475-925X-4-53Search in Google Scholar PubMed PubMed Central

Rivolta, D., Heidegger, T., Scheller, B., Sauer, A., Schaum, M., Birkner, K., Singer, W., Wibral, M., and Uhlhaas, P.J. (2015). Ketamine dysregulates the amplitude and connectivity of high-frequency oscillations in cortical–subcortical networks in humans: evidence from resting-state magnetoencephalography-recordings. Schizophr. Bull. 41, 1105–1114.10.1093/schbul/sbv051Search in Google Scholar PubMed PubMed Central

Robson, M.J., Elliott, M., Seminerio, M.J., and Matsumoto, R.R. (2012). Evaluation of sigma (σ) receptors in the antidepressant-like effects of ketamine in vitro and in vivo. Eur. Neuropsychopharmacol. 22, 308–317.10.1016/j.euroneuro.2011.08.002Search in Google Scholar PubMed

Roopun, A.K., Middleton, S.J., Cunningham, M.O., LeBeau, F.E., Bibbig, A., Whittington, M.A., and Traub, R.D. (2006). A beta2-frequency (20–30 Hz) oscillation in nonsynaptic networks of somatosensory cortex. Proc. Natl. Acad. Sci. 103, 15646–15650.10.1073/pnas.0607443103Search in Google Scholar PubMed PubMed Central

Rotaru, D.C., Yoshino, H., Lewis, D.A., Ermentrout, G.B., and Gonzalez-Burgos, G. (2011). Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: relevance for schizophrenia. J. Neurosci. 31, 142–156.10.1523/JNEUROSCI.1970-10.2011Search in Google Scholar PubMed PubMed Central

Roth, B.L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., and Iversen, L. (2013). The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. PLoS One 8, e59334.10.1371/journal.pone.0059334Search in Google Scholar PubMed PubMed Central

Rowland, L.M., Bustillo, J.R., Mullins, P.G., Jung, R.E., Lenroot, R., Landgraf, E., Barrow, R., Yeo, R., Lauriello, J., and Brooks, W.M. (2005). Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study. Am. J. Psychiatry 162, 394–396.10.1176/appi.ajp.162.2.394Search in Google Scholar PubMed

Rowland, L.M., Beason-Held, L., Tamminga, C.A., and Holcomb, H.H. (2010). The interactive effects of ketamine and nicotine on human cerebral blood flow. Psychopharmacology (Berl.) 208, 575–584.10.1007/s00213-009-1758-2Search in Google Scholar PubMed PubMed Central

Salmi, E., Långsjö, J.W., Aalto, S., Någren, K., Metsähonkala, L., Kaisti, K.K., Korpi, E.R., Hietala, J., and Scheinin, H. (2005). Subanesthetic ketamine does not affect 11C-flumazenil binding in humans. Anesth. Analg. 101, 722–725.10.1213/01.ANE.0000156951.83242.8DSearch in Google Scholar PubMed

Sanacora, G. and Schatzberg, A.F. (2015). Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders? Neuropsychopharmacology 40, 259–267.10.1038/npp.2014.261Search in Google Scholar PubMed PubMed Central

Sanacora, G., Smith, M.A., Pathak, S., Su, H.L., Boeijinga, P.H., McCarthy, D.J., and Quirk, M.C. (2014). Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol. Psychiatry 19, 978.10.1038/mp.2013.130Search in Google Scholar PubMed PubMed Central

Sarvas, J. (1987). Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem. Phys. Med. Biol. 32, 11–22.10.1088/0031-9155/32/1/004Search in Google Scholar PubMed

Saunders, J.A., Gandal, M.J., and Siegel, S.J. (2012). NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia. Neurobiol. Dis. 46, 93–100.10.1016/j.nbd.2011.12.049Search in Google Scholar

Schartner, M.M., Carhart-Harris, R.L., Barrett, A.B., Seth, A.K., and Muthukumaraswamy, S.D. (2017). Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin. Sci. Rep. 7, 46421.10.1038/srep46421Search in Google Scholar

Scheeringa, R., Fries, P., Petersson, K.-M., Oostenveld, R., Grothe, I., Norris, D.G., Hagoort, P., and Bastiaansen, M.C.M. (2011). Neuronal dynamics underlying high- and low-frequency EEG oscillations contribute independently to the human BOLD signal. Neuron 69, 572–583.10.1016/j.neuron.2010.11.044Search in Google Scholar

Scheeringa, R., Koopmans, P.J., van Mourik, T., Jensen, O., and Norris, D.G. (2016). The relationship between oscillatory EEG activity and the laminar-specific BOLD signal. Proc. Natl. Acad. Sci. 113, 6761–6766.10.1073/pnas.1522577113Search in Google Scholar

Scheidegger, M., Walter, M., Lehmann, M., Metzger, C., Grimm, S., Boeker, H., Boesiger, P., Henning, A., and Seifritz, E. (2012). Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action. PLoS One 7, e44799.10.1371/journal.pone.0044799Search in Google Scholar

Scheidegger, M., Henning, A., Walter, M., Lehmann, M., Kraehenmann, R., Boeker, H., Seifritz, E., and Grimm, S. (2016). Ketamine administration reduces amygdalo-hippocampal reactivity to emotional stimulation. Hum. Brain Mapp. 37, 1941–1952.10.1002/hbm.23148Search in Google Scholar

Schmidt, A., Ryding, E., and Åkeson, J. (2003). Racemic ketamine does not abolish cerebrovascular autoregulation in the pig. Acta Anaesthesiol. Scand. 47, 569–575.10.1034/j.1399-6576.2003.00089.xSearch in Google Scholar

Schomer, D.L. and Da Silva, F.L. (2012). Niedermeyer’s Electroencephalography: Basic Principles, Clinical Applications, and Related Fields (Philadelphia: Lippincott Williams & Wilkins).Search in Google Scholar

Schroeder, C.E., Tenke, C.E., and Givre, S.J. (1992). Subcortical contributions to the surface-recorded flash-VEP in the awake macaque. Electroencephalogr. Clin. Neurophysiol. Potentials Sect. 84, 219–231.10.1016/0168-5597(92)90003-TSearch in Google Scholar

Schroeder, C.E., Lakatos, P., Kajikawa, Y., Partan, S., and Puce, A. (2008). Neuronal oscillations and visual amplification of speech. Trends Cogn. Sci. 12, 106–113.10.1016/j.tics.2008.01.002Search in Google Scholar PubMed PubMed Central

Schroeder, K.E., Irwin, Z.T., Gaidica, M., Bentley, J.N., Patil, P.G., Mashour, G.A., and Chestek, C.A. (2016). Disruption of corticocortical information transfer during ketamine anesthesia in the primate brain. Neuroimage 134, 459–465.10.1016/j.neuroimage.2016.04.039Search in Google Scholar PubMed PubMed Central

Schuh, F.T. (1975). Influence of ketamine on human plasma cholinesterase. Br. J. Anaesth. 47, 1315–1319.10.1093/bja/47.12.1315Search in Google Scholar

Schwartz, M.S., Virden, S., and Scott, D.F. (1974). Effects of ketamine on the electroencephalograph. Anaesthesia 29, 135.10.1111/j.1365-2044.1974.tb00611.xSearch in Google Scholar

Seeman, P., Ko, F., and Tallerico, T. (2005). Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics. Mol. Psychiatry 10, 877–883.10.1038/sj.mp.4001682Search in Google Scholar

Seth, A.K., Barrett, A.B., and Barnett, L. (2015). Granger causality analysis in neuroscience and neuroimaging. J. Neurosci. 35, 3293–3297.10.1523/JNEUROSCI.4399-14.2015Search in Google Scholar

Shah, M.M. (2014). Cortical HCN channels: function, trafficking and plasticity. J. Physiol. 592, 2711–2719.10.1113/jphysiol.2013.270058Search in Google Scholar

Shaw, A.D., Saxena, N., Jackson, L.E., Hall, J.E., Singh, K.D., and Muthukumaraswamy, S.D. (2015). Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. Eur. Neuropsychopharmacol. 25, 1136–1146.10.1016/j.euroneuro.2015.04.012Search in Google Scholar

Shcherbinin, S., Doyle, O., Zelaya, F.O., de Simoni, S., Mehta, M.A., and Schwarz, A.J. (2015). Modulatory effects of ketamine, risperidone and lamotrigine on resting brain perfusion in healthy human subjects. Psychopharmacology (Berl.) 232, 4191–4204.10.1007/s00213-015-4021-zSearch in Google Scholar

Sheline, Y.I., Price, J.L., Yan, Z., and Mintun, M.A. (2010). Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc. Natl. Acad. Sci. 107, 11020–11025.10.1073/pnas.1000446107Search in Google Scholar

Shumake, J., Edwards, E., and Gonzalez-Lima, F. (2003). Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior. Brain Res. 963, 274–281.10.1016/S0006-8993(02)04048-9Search in Google Scholar

Sikand, K.S., Smith, G., and Lambert, D.G. (1995). Ketamine inhibits K+ evoked [3H] noradrenaline release from SH-SY5Y cells by reducing calcium influx. Biochem. Soc. Trans. 23, 417S–417S.10.1042/bst023417sSearch in Google Scholar PubMed

Sinner, B. and Graf, B.M. (2008). Ketamine. In: Modern Anesthetics, J. Schüttler, and H. Schwilden, eds. (Berlin, Heidelberg: Springer Berlin Heidelberg), pp. 313–333.10.1007/978-3-540-74806-9_15Search in Google Scholar

Sleigh, J., Harvey, M., Voss, L., and Denny, B. (2014). Ketamine – more mechanisms of action than just NMDA blockade. Trends Anaesth. Crit. Care 4, 76–81.10.1016/j.tacc.2014.03.002Search in Google Scholar

Smith, G.S., Schloesser, R., Brodie, J.D., Dewey, S.L., Logan, J., Vitkun, S.A., Simkowitz, P., Hurley, A., Cooper, T., and Volkow, N.D. (1998). Glutamate modulation of dopamine measured in vivo with positron emission tomography (PET) and 11 C-raclopride in normal human subjects. Neuropsychopharmacology 18, 18.10.1016/S0893-133X(97)00092-4Search in Google Scholar

Spitzer, B. and Haegens, S. (2017). Beyond the status quo: a role for beta oscillations in endogenous content (Re-) activation. Eneuro ENEURO. 0170-17.2017.10.1523/ENEURO.0170-17.2017Search in Google Scholar

Sridharan, D., Levitin, D.J., and Menon, V. (2008). A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc. Natl. Acad. Sci. 105, 12569–12574.10.1073/pnas.0800005105Search in Google Scholar

Steiner, J., Walter, M., Gos, T., Guillemin, G.J., Bernstein, H.-G., Sarnyai, Z., Mawrin, C., Brisch, R., Bielau, H., zu Schwabedissen, L.M., et al. (2011). Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J. Neuroinflammation 8, 94.10.1186/1742-2094-8-94Search in Google Scholar

Steriade, M. (2000). Corticothalamic resonance, states of vigilance and mentation. Neuroscience 101, 243–276.10.1016/S0306-4522(00)00353-5Search in Google Scholar

Steriade, M., Gloor, P., Llinas, R.R., Da Silva, F.L., and Mesulam, M.-M. (1990). Basic mechanisms of cerebral rhythmic activities. Electroencephalogr. Clin. Neurophysiol. 76, 481–508.10.1016/0013-4694(90)90001-ZSearch in Google Scholar

Stone, J., Kotoula, V., Dietrich, C., De Simoni, S., Krystal, J.H., and Mehta, M.A. (2015). Perceptual distortions and delusional thinking following ketamine administration are related to increased pharmacological MRI signal changes in the parietal lobe. J. Psychopharmacol. (Oxf.) 29, 1025–1028.10.1177/0269881115592337Search in Google Scholar PubMed

Stone, J.M., Dietrich, C., Edden, R., Mehta, M.A., De Simoni, S., Reed, L.J., Krystal, J.H., Nutt, D., and Barker, G.J. (2012). Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology. Mol. Psychiatry 17, 664–665.10.1038/mp.2011.171Search in Google Scholar PubMed PubMed Central

Su, T.-P. and Hayashi, T. (2003). Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction. Curr. Med. Chem. 10, 2073–2080.10.2174/0929867033456783Search in Google Scholar PubMed

Swettenham, J.B., Muthukumaraswamy, S.D., and Singh, K.D. (2013). BOLD responses in human primary visual cortex are insensitive to substantial changes in neural activity. Front. Hum. Neurosci. 7, 76.10.3389/fnhum.2013.00076Search in Google Scholar PubMed PubMed Central

Tai, Y.F. (2004). Applications of positron emission tomography (PET) in neurology. J. Neurol. Neurosurg. Psychiatry 75, 669–676.10.1142/9781860948961_0014Search in Google Scholar

Takahata, R. and Moghaddam, B. (2003). Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine. Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol. 28, 1117–1124.10.1038/sj.npp.1300127Search in Google Scholar PubMed

Tao, R. and Auerbach, S.B. (1994). Anesthetics block morphine-induced increases in serotonin release in rat CNS. Synapse 18, 307–314.10.1002/syn.890180406Search in Google Scholar PubMed

Tiesinga, P. and Sejnowski, T.J. (2009). Cortical enlightenment: are attentional gamma oscillations driven by ING or PING? Neuron 63, 727–732.10.1016/j.neuron.2009.09.009Search in Google Scholar PubMed PubMed Central

Van den Aardweg, J.G., and Karemaker, J.M. (2002). Influence of chemoreflexes on respiratory variability in healthy subjects. Am. J. Respir. Crit. Care Med. 165, 1041–1047.10.1164/ajrccm.165.8.2104100Search in Google Scholar PubMed

Varnäs, K., Halldin, C., and Hall, H. (2004). Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum. Brain Mapp. 22, 246–260.10.1002/hbm.20035Search in Google Scholar PubMed PubMed Central

Vijayan, S. and Kopell, N.J. (2012). Thalamic model of awake alpha oscillations and implications for stimulus processing. Proc. Natl. Acad. Sci. 109, 18553–18558.10.1073/pnas.1215385109Search in Google Scholar PubMed PubMed Central

Vlisides, P.E., Bel-Bahar, T., Lee, U., Li, D., Kim, H., Janke, E., Tarnal, V., Pichurko, A.B., McKinney, A.M., and Kunkler, B.S. (2017). Neurophysiologic correlates of ketamine sedation and anesthesiaa high-density electroencephalography study in healthy volunteers. Anesthesiol. J. Am. Soc. Anesthesiol. 127, 58–69.10.1097/ALN.0000000000001671Search in Google Scholar PubMed PubMed Central

Vlisides, P.E., Bel-Bahar, T., Nelson, A., Chilton, K., Smith, E., Janke, E., Tarnal, V., Picton, P., Harris, R.E., and Mashour, G.A. (2018). Subanaesthetic ketamine and altered states of consciousness in humans. Br. J. Anaesth.10.1016/j.bja.2018.03.011Search in Google Scholar

Vollenweider, F.X. and Kometer, M. (2010). The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nat. Rev. Neurosci. 11, 642–651.10.1038/nrn2884Search in Google Scholar

Vollenweider, F.X., Leenders, K.L., Øye, I., Hell, D., and Angst, J. (1997a). Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)-and (R)-ketamine in healthy volunteers using positron emission tomography (PET). Eur. Neuropsychopharmacol. 7, 25–38.10.1016/S0924-977X(96)00042-9Search in Google Scholar

Vollenweider, F.X., Leenders, K.L., Scharfetter, C., Antonini, A., Maguire, P., Missimer, J., and Angst, J. (1997b). Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F] fluorodeoxyglucose (FDG). Eur. Neuropsychopharmacol. 7, 9–24.10.1016/S0924-977X(96)00039-9Search in Google Scholar

Vollenweider, F.X., Vontobel, P., Øye, I., Hell, D., and Leenders, K.L. (2000). Effects of (S)-ketamine on striatal dopamine: a [11C] raclopride PET study of a model psychosis in humans. J. Psychiatr. Res. 34, 35–43.10.1016/S0022-3956(99)00031-XSearch in Google Scholar

Wagner, L.E., Gingrich, K.J., Kulli, J.C., and Yang, J. (2001). Ketamine blockade of voltage-gated sodium channels: evidence for a shared receptor site with local anesthetics. Anesthesiol. J. Am. Soc. Anesthesiol. 95, 1406–1413.10.1097/00000542-200112000-00020Search in Google Scholar PubMed

Wang, H.-X. and Gao, W.-J. (2009). Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex. Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol. 34, 2028–2040.10.1038/npp.2009.20Search in Google Scholar PubMed PubMed Central

Wang, H.-X. and Gao, W.-J. (2012). Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex. Neuropharmacology 62, 1808–1822.10.1016/j.neuropharm.2011.11.024Search in Google Scholar PubMed PubMed Central

Wang, C., Ulbert, I., Schomer, D.L., Marinkovic, K., and Halgren, E. (2005). Responses of human anterior cingulate cortex microdomains to error detection, conflict monitoring, stimulus-response mapping, familiarity, and orienting. J. Neurosci. 25, 604–613.10.1523/JNEUROSCI.4151-04.2005Search in Google Scholar PubMed PubMed Central

Wang, D.-S., Penna, A., and Orser, B.A. (2017). Ketamine increases the function of γ-aminobutyric acid type A receptors in hippocampal and cortical neurons. J. Am. Soc. Anesthesiol. 126, 666–677.10.1097/ALN.0000000000001483Search in Google Scholar PubMed

Ward, L.M. (2003). Synchronous neural oscillations and cognitive processes. Trends Cogn. Sci. 7, 553–559.10.1016/j.tics.2003.10.012Search in Google Scholar

Warden, D., Rush, A.J., Trivedi, M.H., Fava, M., and Wisniewski, S.R. (2007). The STAR* D Project results: a comprehensive review of findings. Curr. Psychiatry Rep. 9, 449–459.10.1007/s11920-007-0061-3Search in Google Scholar

Whiting, P.J. (2003). GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery? Drug Discov. Today 8, 445–450.10.1016/S1359-6446(03)02703-XSearch in Google Scholar

Whittington, M.A., Cunningham, M.O., LeBeau, F.E., Racca, C., and Traub, R.D. (2011). Multiple origins of the cortical gamma rhythm. Dev. Neurobiol. 71, 92–106.10.1002/dneu.20814Search in Google Scholar PubMed

Wong, J.J., O’Daly, O., Mehta, M.A., Young, A.H., and Stone, J.M. (2016). Ketamine modulates subgenual cingulate connectivity with the memory-related neural circuit – a mechanism of relevance to resistant depression? PeerJ 4, e1710.10.7717/peerj.1710Search in Google Scholar PubMed PubMed Central

Woolf, T.F. and Adams, J.D. (1987). Biotransformation of ketamine, (Z)-6-hydroxyketamine, and (E)-6-hydroxyketamine by rat, rabbit, and human liver microsomal preparations. Xenobiotica 17, 839–847.10.3109/00498258709043993Search in Google Scholar PubMed

World Health Organization (2017). WHO Model List of Essential Medicines: 20th list (March 2017).Search in Google Scholar

Xing, D., Yeh, C.-I., and Shapley, R.M. (2009). Spatial spread of the local field potential and its laminar variation in visual cortex. J. Neurosci. 29, 11540–11549.10.1523/JNEUROSCI.2573-09.2009Search in Google Scholar PubMed PubMed Central

Yamakura, T., Chavez-Noriega, L.E., and Harris, R.A. (2000). Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine. Anesthesiol. J. Am. Soc. Anesthesiol. 92, 1144–1153.10.1097/00000542-200004000-00033Search in Google Scholar PubMed

Yan, C.-G., Chen, X., Li, L., Castellanos, F.X., Bai, T.-J., Bo, Q.-J., Cao, J., Chen, G.-M., Chen, N.-X., Chen, W., et al. (2019). Reduced default mode network functional connectivity in patients with recurrent major depressive disorder. Proc. Natl. Acad. Sci. 116, 9078–9083.10.1073/pnas.1900390116Search in Google Scholar PubMed PubMed Central

Yang, Y., Cui, Y., Sang, K., Dong, Y., Ni, Z., Ma, S., and Hu, H. (2018). Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature 554, 317.10.1038/nature25509Search in Google Scholar PubMed

Yue, B.W. and Huguenard, J.R. (2001). The role of H-current in regulating strength and frequency of thalamic network oscillations. Thalamus Relat. Syst. 1, 95–103.10.1017/S1472928801000097Search in Google Scholar

Zanos, P. and Gould, T.D. (2018). Mechanisms of ketamine action as an antidepressant. Mol. Psychiatry 23, 801–811.10.1038/mp.2017.255Search in Google Scholar

Zanos, P., Moaddel, R., Morris, P.J., Georgiou, P., Fischell, J., Elmer, G.I., Alkondon, M., Yuan, P., Pribut, H.J., and Singh, N.S. (2016). NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533, 481–486.10.1038/nature17998Search in Google Scholar

Zanos, P., Moaddel, R., Morris, P.J., Riggs, L.M., Highland, J.N., Georgiou, P., Pereira, E.F., Albuquerque, E.X., Thomas, C.J., and Zarate, C.A. (2018). Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms. Pharmacol. Rev. 70, 621–660.10.1124/pr.117.015198Search in Google Scholar

Zanos, P., Highland, J.N., Stewart, B.W., Georgiou, P., Jenne, C.E., Lovett, J., Morris, P.J., Thomas, C.J., Moaddel, R., Zarate, C.A., et al. (2019). (2R,6R)-Hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions. Proc. Natl. Acad. Sci. USA 201819540.Search in Google Scholar

Zarate, C.A., Singh, J.B., Carlson, P.J., Brutsche, N.E., Ameli, R., Luckenbaugh, D.A., Charney, D.S., and Manji, H.K. (2006). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch. Gen. Psychiatry 63, 856–864.10.1001/archpsyc.63.8.856Search in Google Scholar

Zarate, C.A., Brutsche, N., Laje, G., Luckenbaugh, D.A., Venkata, S.L.V., Ramamoorthy, A., Moaddel, R., and Wainer, I.W. (2012). Relationship of ketamine’s plasma metabolites with response, diagnosis, and side effects in major depression. Biol. Psychiatry 72, 331–338.10.1016/j.biopsych.2012.03.004Search in Google Scholar

Zhang, Y., Yoshida, T., Katz, D.B., and Lisman, J.E. (2012). NMDAR antagonist action in thalamus imposes delta oscillations on the hippocampus. J. Neurophysiol. 107, 3181–3189.10.1152/jn.00072.2012Search in Google Scholar

Zhao, Y. and Sun, L. (2008). Antidepressants modulate the in vitro inhibitory effects of propofol and ketamine on norepinephrine and serotonin transporter function. J. Clin. Neurosci. 15, 1264–1269.10.1016/j.jocn.2007.11.007Search in Google Scholar

Zhao, X., Venkata, S.L.V., Moaddel, R., Luckenbaugh, D.A., Brutsche, N.E., Ibrahim, L., Zarate Jr, C.A., Mager, D.E., and Wainer, I.W. (2012). Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression. Br. J. Clin. Pharmacol. 74, 304–314.10.1111/j.1365-2125.2012.04198.xSearch in Google Scholar

Zhou, Z.-S. and Zhao, Z.-Q. (2000). Ketamine blockage of both tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels of rat dorsal root ganglion neurons. Brain Res. Bull. 52, 427–433.10.1016/S0361-9230(00)00283-5Search in Google Scholar

Zhou, C., Douglas, J.E., Kumar, N.N., Shu, S., Bayliss, D.A., and Chen, X. (2013). Forebrain HCN1 channels contribute to hypnotic actions of ketamine. J. Am. Soc. Anesthesiol. 118, 785–795.10.1097/ALN.0b013e318287b7c8Search in Google Scholar PubMed PubMed Central

Zou, Q.-H., Zhu, C.-Z., Yang, Y., Zuo, X.-N., Long, X.-Y., Cao, Q.-J., Wang, Y.-F., and Zang, Y.-F. (2008). An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF. J. Neurosci. Methods 172, 137–141.10.1016/j.jneumeth.2008.04.012Search in Google Scholar PubMed PubMed Central

Zou, X., Patterson, T.A., Divine, R.L., Sadovova, N., Zhang, X., Hanig, J.P., Paule, M.G., Slikker, W., and Wang, C. (2009). Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain. Int. J. Dev. Neurosci. 27, 727–731.10.1016/j.ijdevneu.2009.06.010Search in Google Scholar PubMed

Received: 2019-09-10
Accepted: 2020-01-26
Published Online: 2020-05-05
Published in Print: 2020-07-28

©2020 Walter de Gruyter GmbH, Berlin/Boston

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