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Licensed Unlicensed Requires Authentication Published by De Gruyter July 17, 2020

A new method to predict anomaly in brain network based on graph deep learning

  • Jalal Mirakhorli EMAIL logo , Hamidreza Amindavar and Mojgan Mirakhorli


Functional magnetic resonance imaging a neuroimaging technique which is used in brain disorders and dysfunction studies, has been improved in recent years by mapping the topology of the brain connections, named connectopic mapping. Based on the fact that healthy and unhealthy brain regions and functions differ slightly, studying the complex topology of the functional and structural networks in the human brain is too complicated considering the growth of evaluation measures. One of the applications of irregular graph deep learning is to analyze the human cognitive functions related to the gene expression and related distributed spatial patterns. Since a variety of brain solutions can be dynamically held in the neuronal networks of the brain with different activity patterns and functional connectivity, both node-centric and graph-centric tasks are involved in this application. In this study, we used an individual generative model and high order graph analysis for the region of interest recognition areas of the brain with abnormal connection during performing certain tasks and resting-state or decompose irregular observations. Accordingly, a high order framework of Variational Graph Autoencoder with a Gaussian distributer was proposed in the paper to analyze the functional data in brain imaging studies in which Generative Adversarial Network is employed for optimizing the latent space in the process of learning strong non-rigid graphs among large scale data. Furthermore, the possible modes of correlations were distinguished in abnormal brain connections. Our goal was to find the degree of correlation between the affected regions and their simultaneous occurrence over time. We can take advantage of this to diagnose brain diseases or show the ability of the nervous system to modify brain topology at all angles and brain plasticity according to input stimuli. In this study, we particularly focused on Alzheimer’s disease.

Corresponding author: Jalal Mirakhorli, Department of Electrical Engineering, Amirkabir University of Technology, Tehran, Iran, E-mail:


The authors gratefully acknowledge the assistance provided by the Medical Genetic Lab, Iranian Comprehensive Hemophilia Care Center (ICHCC).

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.


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Received: 2019-11-26
Accepted: 2020-02-01
Published Online: 2020-07-17
Published in Print: 2020-08-27

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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