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Licensed Unlicensed Requires Authentication Published by De Gruyter October 11, 2014

The Method for Identification of Hierarchical Organization of Protein Sequences

  • Anastasia A. Anashkina EMAIL logo and Alexei N. Nekrasov


The paper describes a newmethod of Information Structure Analysis (ISAN) for protein sequences. The method uses a new approximation for description of protein sequences, which allows us to detect hierarchically organized elements (Information Structure Elements (ISEL)) in them. It is shown that elements of the higher hierarchy level of information structure correspond to stable elements in the spatial structure of globular proteins. Based on the ISAN method, we propose an approach to design of the new sequences of recombinant proteins. The proposed approach was confirmed experimentally in the case of obtaining functionally active recombinant proteins.

Received: 2014-5-14
Accepted: 2014-6-25
Published Online: 2014-10-11
Published in Print: 2014-10-1

© 2014 by Walter de Gruyter Berlin/Boston

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