Electro-Mechanical Coupling in a One-Dimensional Model of Heart Muscle fiber

Leonid B. Katsnelson; Natalia A. Vikulova; Alexander G. Kursanov; Olga E. Solovyova; Vladimir S. Markhasin

doi:10.1515/rnam-2014-0022

Published by De Gruyter October 11, 2014

Electro-Mechanical Coupling in a One-Dimensional Model of Heart Muscle fiber

Leonid B. Katsnelson , Natalia A. Vikulova , Alexander G. Kursanov , Olga E. Solovyova and Vladimir S. Markhasin

From the journal Russian Journal of Numerical Analysis and Mathematical Modelling

https://doi.org/10.1515/rnam-2014-0022

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Abstract

We developed a mathematical model that describes heart muscle fiber as a one-dimensional continuous medium of electrically and mechanically coupled cardiomyocytes through which electrical excitation propagates and initiates muscle contraction. The generic model simulates bilateral relations between the electrical and the mechanical activity of cardiomyocytes in the tissue and accounts for both intracellular and intercellular electro-mechanical couplings and mechano-electric feedback mechanisms.

Keywords: Cardiac mechano-electric feedback; heterogeneous myocardium; mathematical modelling

Received: 2014-4-25

Accepted: 2014-6-25

Published Online: 2014-10-11

Published in Print: 2014-10-1

Electro-Mechanical Coupling in a One-Dimensional Model of Heart Muscle fiber

Abstract

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