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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access June 17, 2016

RNA Toehold Interactions Initiate Conditional Gene Silencing

Paul Zakrevsky , Eckart Bindewald and Bruce A Shapiro

References

[1] McNamara JO, et al. (2006) Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol 24(8):1005-1015. 10.1038/nbt1223Search in Google Scholar

[2] Zhou J, et al. (2013) Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol Ther 21(1):192-200. 10.1038/mt.2012.226Search in Google Scholar

[3] Shu D, et al. (2015) Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology. ACS Nano 9(10):9731-9740. 10.1021/acsnano.5b02471Search in Google Scholar

[4] Afonin KA, et al. (2013) Activation of different split functionalities on re-association of RNA-DNA hybrids. Nat Nanotechnol 8(4):296-304. 10.1038/nnano.2013.44Search in Google Scholar

[5] Hochrein LM, Schwarzkopf M, Shahgholi M, Yin P, & Pierce NA (2013) Conditional Dicer substrate formation via shape and sequence transduction with small conditional RNAs. J Am Chem Soc 135(46):17322-17330. 10.1021/ja404676xSearch in Google Scholar

[6] Afonin KA, et al. (2014) Co-transcriptional production of RNA-DNA hybrids for simultaneous release of multiple split functionalities. Nucleic Acids Res 42(3):2085-2097. 10.1093/nar/gkt1001Search in Google Scholar

[7] Afonin KA, et al. (2016) The Use of Minimal RNA Toeholds to Trigger the Activation of Multiple Functionalities. Nano Lett 16(3):1746-1753. 10.1021/acs.nanolett.5b04676Search in Google Scholar

[8] Bindewald E, et al. (2016) Multistrand Structure Prediction of Nucleic Acid Assemblies and Design of RNA Switches. Nano Lett 16(3):1726-1735. 10.1021/acs.nanolett.5b04651Search in Google Scholar

[9] Shu D, Shu Y, Haque F, Abdelmawla S, & Guo P (2011) Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics. Nat Nanotechnol 6(10):658-667. 10.1038/nnano.2011.105Search in Google Scholar

[10] Afonin KA, et al. (2014) Multifunctional RNA nanoparticles. Nano Lett 14(10):5662-5671. 10.1021/nl502385kSearch in Google Scholar

Received: 2016-4-20
Accepted: 2016-5-5
Published Online: 2016-6-17

© 2016 Paul Zakrevsky et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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