Accessible Requires Authentication Published by De Gruyter February 10, 2011

Alcohol-induced behavior change in zebrafish models

David J. Echevarria, Christina N. Toms and David J. Jouandot
From the journal

Abstract

Zebrafish are at the forefront of neurobiological research and have been gaining popularity as a viable and valid behavioral model in a variety of research applications (e.g., assessing drug induced behavioral changes). This model becomes even more attractive when considering the behavioral changes that follow exposure to compounds that are water-soluble. As such, several studies have implicated both acute and chronic ethanol exposure in the modulation of zebrafish behavior. Within this arena there appears to be a common trend across multiple studies. As with many drugs ethanol appears to influence behavior in a dose-dependent manner. In this review, we compare and contrast several studies that measure behavior as a result of alcohol exposure. Appended to this review are pilot data that report zebrafish blood alcohol concentrations as a function of acute exposure.


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Published Online: 2011-02-10
Published in Print: 2011-02-01

©2011 by Walter de Gruyter Berlin New York