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Licensed Unlicensed Requires Authentication Published by De Gruyter February 10, 2011

Alcohol-induced behavior change in zebrafish models

David J. Echevarria , Christina N. Toms and David J. Jouandot EMAIL logo
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Abstract

Zebrafish are at the forefront of neurobiological research and have been gaining popularity as a viable and valid behavioral model in a variety of research applications (e.g., assessing drug induced behavioral changes). This model becomes even more attractive when considering the behavioral changes that follow exposure to compounds that are water-soluble. As such, several studies have implicated both acute and chronic ethanol exposure in the modulation of zebrafish behavior. Within this arena there appears to be a common trend across multiple studies. As with many drugs ethanol appears to influence behavior in a dose-dependent manner. In this review, we compare and contrast several studies that measure behavior as a result of alcohol exposure. Appended to this review are pilot data that report zebrafish blood alcohol concentrations as a function of acute exposure.


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Published Online: 2011-02-10
Published in Print: 2011-02-01

©2011 by Walter de Gruyter Berlin New York

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