Accessible Unlicensed Requires Authentication Published by De Gruyter February 10, 2011

Zebrafish models to study drug abuse-related phenotypes

Adam Stewart, Keith Wong, Jonathan Cachat, Siddharth Gaikwad, Evan Kyzar, Nadine Wu, Peter Hart, Valerie Piet, Eli Utterback, Marco Elegante, David Tien and Allan V. Kalueff
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Abstract

Mounting evidence implicates the zebrafish (Danio rerio) as a promising model species for reward and addiction research. Modeling drug abuse-related behavior in both adult and larval zebrafish produced a wealth of clinically translatable data, also demonstrating their sensitivity to various drugs of abuse and the ability to develop tolerance. Several studies have also applied withdrawal paradigms to model the adverse effects of drug abuse in zebrafish. In this review, we summarize recent findings of a wide spectrum of zebrafish drug abuse-related behavioral and physiological phenotypes, discuss the existing challenges, and outline potential future directions of research in this field.


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Published Online: 2011-02-10
Published in Print: 2011-02-01

©2011 by Walter de Gruyter Berlin New York