It is usually held that by the turn of the millennium Latin Christians stopped enslaving their fellow-believers from within Europe. Scholars have therefore tended to define the late medieval type of domestic slaves in Italian and Iberian households, most of whom had been traded from the Eastern Mediterranean and the Black Sea region to Europe, by their cultural and religious difference. Yet, the numerous Christians from the Balkans who came across the Adriatic Sea to the West (and especially to Venice) clearly complicate the picture. They were mostly under twelve years of age and could be purchased at a very low price. The paper examines the commercial policy of the Venetian Senate in respect of the Adriatic human trafficking and sounds the strategies Venetian merchants used in order to pursue their interests, within and outside the legal framework set by the state authorities East and West of the Adriatic Sea.