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Characterization of electrochemical flow cell configurations with implemented disposable electrodes for the direct coupling to mass spectrometry

Charakterisierung elektrochemischer Fließzell-Konfigurationen mit implementierten Einwegelektroden zur direkten Kopplung mit der Massenspektrometrie
  • Thomas Herl

    Thomas Herl studied chemistry at the University of Regensburg. His M.Sc. thesis was concerned with the hyphenation of electrochemical systems with mass spectrometry.

    University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany, Tel.: +49 941 943 4012

    and Frank-Michael Matysik

    Frank-Michael Matysik is Professor of Analytical Chemistry at the University of Regensburg (Bavaria, Germany). He studied chemistry at the University of Leipzig and received his Ph.D. (1994) and “Habilitation” (2001) degrees from the University of Leipzig. From 2001 to 2008 he was “Privatdozent” for Analytical Chemistry at the same university. In 2008 he accepted the position of a professor of chemistry at the University of Regensburg where he is representing the field of instrumental analytical methods. His research interests include electroanalysis, instrumental analytical developments, chromatographic and electrophoretic separation techniques, mass spectrometry, hyphenated analytical systems, and miniaturized sample preparation techniques.

    University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany, Tel.: +49 941 943 4548

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From the journal tm - Technisches Messen

Abstract

The characterization of the redox behavior of analytes is a very important aspect for many applications. Pure electrochemical approaches can provide useful information on electroactive species, but are of limited use regarding the identification of generated species. The hyphenation of electrochemistry and mass spectrometry (EC-MS) is a powerful method to investigate redox systems. In the present work, we show a simple approach to on-line EC-MS based on the application of electrochemical flow cells with implemented disposable electrodes. They are connected to electrospray ionization mass spectrometry (ESI-MS) via fused silica capillary tubing. The modularity of the flow cells offers a high flexibility of experimental setup and settings, so that a fast detection of oxidation or reduction products can be achieved. The usage of disposable electrodes guarantees a high level of quality assurance for EC-MS measurements.

Zusammenfassung

Die Charakterisierung des Redoxverhaltens verschiedener Analyte ist ein sehr bedeutsamer Aspekt für viele Anwendungen. Auf reiner Elektrochemie basierende Ansätze können nützliche Ergebnisse liefern, sind jedoch im Hinblick auf die Identifizierung auftretender Spezies limitiert. Die Kopplung von Elektrochemie und Massenspektrometrie (EC-MS) ist eine sehr leistungsfähige Methode, um Redoxsysteme zu untersuchen. In der vorgestellten Arbeit wird ein einfacher Ansatz zur on-line Kopplung von Elektrochemie und Massenspektrometrie präsentiert, der auf der Anwendung elektrochemischer Fließzellen mit implementierten Einwegelektroden basiert. Diese werden über Kapillaren aus synthetischem Quarzglas an ein Massenspektrometer mit Elektrospray-Ionisation gekoppelt. Die Modularität dieser Zellen bietet eine hohe Flexibilität bezüglich des instrumentellen Aufbaus und der Einstellungen, so dass eine schnelle Detektion von Oxidations- oder Reduktionsprodukten erfolgen kann. Die Anwendung von Einwegelektroden garantiert hierbei ein hohes Niveau der Qualitätssicherung für EC-MS-Messungen.

About the authors

Thomas Herl

Thomas Herl studied chemistry at the University of Regensburg. His M.Sc. thesis was concerned with the hyphenation of electrochemical systems with mass spectrometry.

University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany, Tel.: +49 941 943 4012

Frank-Michael Matysik

Frank-Michael Matysik is Professor of Analytical Chemistry at the University of Regensburg (Bavaria, Germany). He studied chemistry at the University of Leipzig and received his Ph.D. (1994) and “Habilitation” (2001) degrees from the University of Leipzig. From 2001 to 2008 he was “Privatdozent” for Analytical Chemistry at the same university. In 2008 he accepted the position of a professor of chemistry at the University of Regensburg where he is representing the field of instrumental analytical methods. His research interests include electroanalysis, instrumental analytical developments, chromatographic and electrophoretic separation techniques, mass spectrometry, hyphenated analytical systems, and miniaturized sample preparation techniques.

University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany, Tel.: +49 941 943 4548

Received: 2017-1-3
Revised: 2017-4-13
Accepted: 2017-5-3
Published Online: 2017-5-30
Published in Print: 2017-10-26

©2017 Walter de Gruyter Berlin/Boston

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