Accessible Unlicensed Requires Authentication Published by De Gruyter November 30, 2021

Alcohol-Based Sanitizers: An Effective Means for Preventing the Spread of Contagious Viral Diseases Including COVID-19

Desinfektionsmittel auf Alkoholbasis: Ein wirksames Mittel zur Verhinderung der Ausbreitung ansteckender Viruskrankheiten einschließlich COVID-19
Narendra Kumar Chaudhary, Biswash Guragain, Summi Rai, Nabina Chaudhary, Rahul Chaudhary, KM Sachin, Reena Lamichhane-Khadka and Ajaya Bhattarai

Abstract

The global community is struggling with the highly contagious COVID-19. Returning to \normal life" now poses risks, and the use of appropriate protective measures has become necessary to continue daily life and protect public health. The main protective measures to prevent transmission of COVID-19 are masks, soaps and disinfectants. Because coronavirus is a \lipid-enveloped virus", it is very sensitive to lipid-dissolving chemicals and can therefore be effectively removed by washing hands sufficiently with soap and water. However, using an alcohol-based disinfectant is a more viable option for outdoor use. Alcohol-based disinfectants are inexpensive, immediately effective, easy to use and better tolerated by the skin compared to other disinfectants. WHO recommends disinfectants containing 75% isopropanol or 80% ethanol as highly effective in inactivating the SARS-CoV-2-virus. The current review discusses the role of alcohol-based hand sanitizers (ABHS) in preventing the spread of viruses, their side effects on human health, and suggests the use of alcohol-based sanitizers as potentially effective in combating the current epidemic.

Zusammenfassung

Die Weltgemeinschaft kämpft mit dem hochansteckenden COVID-19. Die Rückkehr zu einem ,,normalen Leben\ birgt nun Risiken, und die Anwendung geeigneter Schutzmaßnahmen ist notwendig geworden, um das tägliche Leben weiterzuführen und die öffentliche Gesundheit zu schützen. Die wichtigsten Schutzmaßnahmen zur Verhinderung der Übertragung von COVID-19 sind Masken, Seifen und Desinfektionsmittel. Da das Coronavirus ein ,,lipidumhülltes Virus\ ist, reagiert es sehr empfindlich auf lipidauflösende Chemikalien und kann daher durch ausreichendes Waschen der Hände mit Wasser und Seife effektiv entfernt werden. Die Verwendung eines Desinfektionsmittels auf Alkoholbasis ist jedoch eine praktikablere Option für den Einsatz im Freien. Desinfektionsmittel auf Alkoholbasis sind preiswert, sofort wirksam, einfach anzuwenden und werden im Vergleich zu anderen Desinfektionsmitteln besser von der Haut vertragen. Die WHO empfiehlt Desinfektionsmitteln mit 75% Isopropanol oder 80% Ethanol als hochwirksam bei der Inaktivierung des SARS-CoV-2-Virus. Die aktuelle Übersichtsarbeit diskutiert die Rolle von alkoholbasierten Händedesinfektionsmitteln bei der Verhinderung der Ausbreitung von Viren, ihre Nebenwirkungen auf die menschliche Gesundheit und schlägt die Verwendung von alkoholbasierten Desinfektionsmitteln als potenziell wirksam bei der Bekämpfung der aktuellen Epidemie vor.


Dr. Ajaya Bhattarai Department of Chemistry, M.M.A.M.C (Tribhuvan University) Biratnagar Nepal

References

1 Zheng, J.: SARS-coV-2: An emerging coronavirus that causes a global threat, Int. J. Biol. Sci. 16 (2020) 1678–1685. PMid:32226285; DOI:10.7150/ijbs.45053 Search in Google Scholar

2 Wang, L., Wang, Y., Ye, D. and Liu, Q.: A review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence, Int. J. Antimicrob. Agents. (2020). PMid:32201353; DOI:10.1016/j.ijantimicag.2020.105948 Search in Google Scholar

3 Andersen, K. G., Rambaut, A., Lipkin, W. I., Holmes, E. C. and Garry, R. F. : The proximal origin of SARS-CoV-2, Nat. Med. (2020). PMid:32284615; DOI:10.1038/s41591-020-0820-9 Search in Google Scholar

4 Sun, G. Q., Wang, S. F., Li, M. T., Li, L., Zhang, J., Zhang, W., Jin, Z. and Feng, G. L.: Transmission dynamics of COVID-19 in Wuhan, China: effects of lockdown and medical resources, Nonlinear Dyn. 101 (2020) 1981–1993. PMid:32836805; DOI:10.1007/s11071-020-05770-9 Search in Google Scholar

5 Bi, Q., Wu, Y., Mei, S., Ye, C., Zou, X., Zhang, Z., Liu, X., Wei, L., Truelove, S. A., Zhang, T., Gao, W., Cheng, C., Tang, X., Wu, X., Wu, Y., Sun, B., Huang, S., Sun, Y., Zhang, J., Ma, T., Lessler, J. and Feng, T.: Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study, Lancet Infect. Dis. (2020). DOI:10.1016/S1473-3099(20)30287-5 Search in Google Scholar

6 Zhang, D. X.: SARS-CoV-2: air/aerosols and surfaces in laboratory and clinical settings, J. Hosp. Infect. (2020). DOI:10.1016/j.jhin.2020.05.001 Search in Google Scholar

7 Leung, N. H. L., Chu, D. K. W., Shiu, E. Y. C., Chan, K. H., McDevitt, J. J., Hau, B. J. P., Yen, H. L., Li, Y., Ip, D. K. M., Peiris, J. S. M., Seto, W. H., Leung, G. M., Milton, D. K. and Cowling, B. J.: Respiratory virus shedding in exhaled breath and efficacy of face masks, Nat. Med. 26 (2020) 676–680. PMid:32371934; DOI:10.1038/s41591-020-0843-2 Search in Google Scholar

8 Leslie, R. A., Zhou, S. S. and Macinga, D. R.: Inactivation of SARS-CoV-2 by commercially available alcohol-based hand sanitizers, Am. J. Infect. Control. (2020) 1–2. PMid:32818578; DOI:10.1016/j.ajic.2020.08.020 Search in Google Scholar

9 Lázaro, G. R., Mukhopadhyay, S. and Hagan, M. F.: Why enveloped viruses need cores – the contribution of a nucleocapsid core to viral budding, Biophys. J. 114 (2018) 619–630. PMid:29414708; DOI:10.1016/j.bpj.2017.11.3782 Search in Google Scholar

10 Spinage, C. A.: Epidemic disease in african history I: micro and macro parasites, zoonoses, introduction, viral and protozoal diseases, in: African Ecol. – Benchmarks Hist. Perspect., 2012: pp. 1–1562. DOI:10.1007/978-3-642-22872-8_25 Search in Google Scholar

11 Opatz, T., Senn-Bilfinger, J. and Richert, C.: Thoughts on what chemists can contribute to fighting SARS-CoV-2 – A short note on hand sanitizers, drug candidates and outreach, Angew. Chemie. 132 (2020) 9320–9324. DOI:10.1002/ange.202004721 Search in Google Scholar

12 Suchomel, M., Kundi, M., Pittet, D., Weinlich, M. and Rotter, M. L.: Testing of the world health organization recommended formulations in their application as hygienic hand rubs and proposals for increased efficacy, Am. J. Infect. Control. 40 (2012) 328–331. DOI:10.1016/j.ajic.2011.06.012 Search in Google Scholar

13 Jairoun, A. A., Al-Hemyari, S. S. and Shahwan, M.: The pandemic of COVID-19 and its implications for the purity and authenticity of alcohol-based hand sanitizers: The health risks associated with falsified sanitizers and recommendations for regulatory and public health bodies, Res. Soc. Adm. Pharm. (2020). PMid:32334979; DOI:10.1016/j.sapharm.2020.04.014 Search in Google Scholar

14 Kratzel, A., Todt, D., V’kovski, P., Steiner, S., Gultom, M., Thao, T. T. N., Ebert, N., Holwerda, M., Steinmann, J., Niemeyer, D., Dijkman, R., Kampf, G., Drosten, C., Steinmann, E., Thiel, V. and Pfaender, S.: Inactivation of severe acute respiratory syndrome coronavirus 2 by WHO-recommended hand rub formulations and alcohols, Emerg. Infect. Dis. 26 (2020) 6–9. DOI:10.3201/eid2607.200915 Search in Google Scholar

15 Gormley, N. J., Bronstein, A. C., Rasimas, J. J., Pao, M., Wratney, A. T., Sun, J., Austin, H. A. and Suffredini, A. F.: The rising incidence of intentional ingestion of ethanol-containing hand sanitizers, Crit. Care Med. 40 (2012) 290–294. PMid:21926580; DOI:10.1097/CCM.0b013e31822f09c0 Search in Google Scholar

16 Liu, Y., Gu, Z., Xia, S., Shi, B., Zhou, X. N., Shi, Y. and Liu, J.: What are the underlying transmission patterns of COVID-19 outbreak? An age-specific social contact characterization, EClinicalMedicine. 22 (2020) 100354. PMid:32313879; DOI:10.1016/j.eclinm.2020.100354 Search in Google Scholar

17 Yadav, T. and Saxena, S. K.: Transmission Cycle of SARS-CoV and SARS-CoV-2, in: Med. Virol., Springer Nature Singapore Pte Ltd., 2020: pp. 33–42. DOI:10.1007/978-981-15-4814-7_4 Search in Google Scholar

18 Yao, M., Zhang, L., Ma, J. and Zhou, L.: On airborne transmission and control of SARS-Cov-2, Sci. Total Environ. J. 731 (2020) 139178. PMid:32388162; DOI:10.1016/j.scitotenv.2020.139178 Search in Google Scholar

19 Amirian, E. S.: Potential fecal transmission of SARS-CoV-2: Current evidence and implications for public health, Int. J. Infect. Dis. 95 (2020) 363–370. PMid:32335340; DOI:10.1016/j.ijid.2020.04.057 Search in Google Scholar

20 Hassan, S. A., Sheikh, F. N., Jamal, S., Ezeh, J. K. and Akhtar, A.: Coronavirus (COVID-19): a review of clinical features, diagnosis, and treatment, Cureus. 12 (2020). DOI:10.7759/cureus.7355 Search in Google Scholar

21 Babeluk, R., Jutz, S., Mertlitz, S., Matiasek, J. and Klaus, C.: Hand hygiene – Evaluation of three disinfectant hand sanitizers in a community setting, PLoS One. 9 (2014) 1–7. PMid:25379773; DOI:10.1371/journal.pone.0111969 Search in Google Scholar

22 Chu, D. K., Akl, E. A., Duda, S., Solo, K., Yaacoub, S. and Schünemann, H. J.: Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis, Lancet. (2020) 1–15. DOI:10.1016/S0140-6736(20)31142-9 Search in Google Scholar

23 Hamedani, S., Farshidfar, N., Ziaei, A. and Pakravan, H.: The dilemma of COVID-19 in dental practice concerning the role of saliva in transmission?: a brief review of current evidence, Eur Oral Res. 54 (2020) 92–100. PMid:33474554; DOI:10.26650/eor.20200050 Search in Google Scholar

24 Zhang, J., Lu, X., Jin, Y. and Zheng, Z.: Hospitals’ responsibility in response to the threat of infectious disease outbreak in the context of the coronavirus disease 2019 (COVID-19) pandemic?: Implications for low- and middle-income countries, Glob. Heal. J. 4 (2020) 113–117. PMid:33294250; DOI:10.1016/j.glohj.2020.11.005 Search in Google Scholar

25 Lai, M. Y. Y., Cheng, P. K. C. and Lim, W. W. L.: Survival of severe acute respiratory syndrome coronavirus, Clin. Infect. Dis. 41 (2005) e67–e71. PMid:16142653; DOI:10.1086/433186 Search in Google Scholar

26 Larson, E. L., Cohen, B. and Baxter, K. A.: Analysis of alcohol-based hand sanitizer delivery systems: Efficacy of foam, gel, and wipes against influenza A (H1N1) virus on hands, Am. J. Infect. Control. 40 (2012) 806–809. PMid:22325728; DOI:10.1016/j.ajic.2011.10.016 Search in Google Scholar

27 Tamimi, A. H., Carlino, S., Edmonds, S. and Gerba, C. P.: Impact of an alcohol-based hand sanitizer intervention on the spread of viruses in homes, Food Env. Virol. 6 (2014) 140–144. PMid:24728950; DOI:10.1007/s12560-014-9141-9 Search in Google Scholar

28 Dietz, L., Horve, P. F., Coil, D. A., Fretz, M., Eisen, J. A. and Van Den Wymelenberg, K.: 2019 novel coronavirus (COVID-19) pandemic: built environment considerations to reduce transmission, Appl. Environ. Sci. 5 (2020). DOI:10.1128/mSystems.00245-20 Search in Google Scholar

29 Kramer, A., Galabov, A. S., Sattar, S. A., Döhner, L., Pivert, A., Payan, C., Wolff, M. H. Yilmaz, A. and Steinmann, J.: Virucidal activity of a new hand disinfectant with reduced ethanol content: comparison with other alcohol-based formulations, J. Hosp. Infect. 62 (2006) 98–106. PMid:16307826; DOI:10.1016/j.jhin.2005.06.020 Search in Google Scholar

30 Rabenau, H. F., Cinatl, J., Morgenstern, B., Bauer, G., Preiser, W. and Doerr, H. W.: Stability and inactivation of SARS coronavirus, Med Microbiol Immunol. 194 (2005) 1–6. PMid:15118911; DOI:10.1007/s00430-004-0219-0 Search in Google Scholar

31 Chin, A. W. H., Chu, J. T. S., Perera, M. R. A., Hui, K. P. Y., Yen, H.-L., Chan, M. C. W., Peiris, M. and Poon, L. L. M.: Stability of SARS-CoV-2 in different environmental conditions, The Lancet Microbe. 5247 (2020) 2004973. DOI:10.1016/s2666-5247(20)30003-3 Search in Google Scholar

32 Van Doremalen, N., Bushmaker, T., Morris, D. H., Holbrook, M. G., Gamble, A., Williamson, B. N., Tamin, A., Harcourt, J. L., Thornburg, N. J., Gerber, S. I., Lloyd-Smith, J. O., De Wit, E. and Munster, V. J.: Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1, N. Engl. J. Med. 382 (2020) 1564–1567. PMid:32182409; DOI:10.1056/NEJMc2004973 Search in Google Scholar

33 Kampf, G., Todt, D., Pfaender, S. and Steinmann, E.: Persistence of corona-viruses on inanimate surfaces and its inactivation with biocidal agents, J. Hosp. Infect. (2020). PMid:32035997; DOI:10.1016/j.jhin.2020.01.022 Search in Google Scholar

34 Steinmann, J.: Surrogate viruses for testing virucidal efficacy of chemical disinfectants, J. Hosp. Infect. 56 (2004) S49–S54. PMid:15110123; DOI:10.1016/j.jhin.2003.12.030 Search in Google Scholar

35 Steinmann, J., Paulmann, D., Becker, B., Bischoff, B., Steinmann, E. and Steinmann, J.: Comparison of virucidal activity of alcohol-based hand sanitizers versus antimicrobial hand soaps in vitro and in vivo, J. Hosp. Infect. 82 (2012) 277–280. PMid:23009803; DOI:10.1016/j.jhin.2012.08.005 Search in Google Scholar

36 Saknimit, M., Inatsuki, I., Sugiyama, Y. and Yagami, K.: Virucidal efficacy of physico-chemical treatments against coronaviruses and parvoviruses of laboratory animals, Exp. Anim. 37 (1988) 341–345. PMid:3416941; DOI:10.1538/expanim1978.37.3_341 Search in Google Scholar

37 World Food and Agricultural Organization of the United Nations, Codex Alimentarius Commission, 21st ed. Search in Google Scholar

38 Hoelzer, K., Fanaselle, W., Pouillot, R., Van Doren, J.M. and Dennis, S.: Virus inactivation on hard surfaces or in suspension by chemical disinfectants?: systematic review and meta-analysis of norovirus surrogates, J. Food Prot. 76 (2013) 1006–1016. JFP-12–438. PMid:23726196; DOI:10.4315/0362-028X Search in Google Scholar

39 Kanamori, H., Weber, D. J. and Rutala, W. A.: The role of the healthcare surface environment in SARS-CoV-2 transmission and potential control measures, Ann. Med. (2020). DOI:10.1093/cid/ciaa1467 Search in Google Scholar

40 Kampf, G.:Efficacy of ethanol against viruses in hand disinfection, J. Hosp. Infect. (2017). DOI:10.1016/j.jhin.2017.08.025 Search in Google Scholar

41 Rabenau, H. F., Kampf, G., Cinatl, J. and Doerr, H. W.: Efficacy of various disinfectants against SARS coronavirus, J. Hosp. Infect. 61 (2005) 107–111. PMid:15923059; DOI:10.1016/j.jhin.2004.12.023 Search in Google Scholar

42 Lee, W. N. and Huang, C. H.: Formation of disinfection byproducts in wash water and lettuce by washing with sodium hypochlorite and peracetic acid sanitizers, Food Chem. X. 1 (2019). DOI:10.1016/j.fochx.2018.100003 Search in Google Scholar

43 Steinmann, J., Becker, B., Bischoff, B., Paulmann, D., Friesland, M., Pietschmann, T., Steinmann, J. and Steinmann, E.: Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization, Am. J. Infect. Control. (2010) 66–68. PMid:19900740; DOI:10.1016/j.ajic.2009.07.009 Search in Google Scholar

44 Siddharta, A., Pfaender, S., jane Vielle, N., Dijkman, R., Friesland, M., Becker, B., Yang, J., Engelmann, M., Todt, D., Windisch, M. P., Brill, F. H., Steinmann, J., Steinmann, J., Becker, S., Alves, M. P., Pietschmann, T., Eickmann, M., Thiel, V. and Steinmann, E.: Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses, J. Infect. Dis. 215 (2017) 902–906. PMid:28453839; DOI:10.1093/infdis/jix046 Search in Google Scholar

45 Schurmann, W. and Eggers, H. J.: Antiviral activity of an alcoholic hand disinfectant. Comparison of the in vitro suspension test with in vivo experiments on hands, and on individual fingertips, Antiviral Res. 3 (1983) 25–41. DOI:10.1016/0166-3542(83)90012-8 Search in Google Scholar

46 Suchomel, M., Kundi, M., Pittet, D. and Rotter, M. L.: Modified world health organization hand rub formulations comply with european efficacy requirements for preoperative surgical hand preparations, Infect. Control Hosp. Epidemiol. 34 (2013) 245–250. PMid:23388358; DOI:10.1086/669528 Search in Google Scholar

47 Suchomel, M. and Rotter, M.: Ethanol in pre-surgical hand rubs?: concentration and duration of application for achieving European Norm EN 12791, J. Hosp. Infect. 77 (2011) 263–266. PMid:21190755; DOI:10.1016/j.jhin.2010.10.014 Search in Google Scholar

48 Mackay, E. M. and Schroeder, C. R.: Virucidal (Rabies and Poliomyelitis) activity of aqueous Urea solutions, 1936. DOI:10.3181/00379727-35-8863C Search in Google Scholar

49 Poli, G., Biondi, P. A., Uberti, F., Ponti, W., Balsari, A. and Cantoni, C.: Virucidal activity of organic acids, Food Chem. 4 (1979) 251–258. DOI:10.1016/0308-8146(79)90012-8 Search in Google Scholar

50 Macinga, D. R., Sattar, S. A., Jaykus, L. A. and Arbogast, J. W.: Improved inactivation of nonenveloped enteric viruses and their surrogates by a novel alcohol-based hand sanitizer, Appl. Environ. Microbiol. 74 (2008) 5047–5052. PMid:18586970; DOI:10.1128/AEM.00487-08 Search in Google Scholar

51 Ionidis, G., Hübscher, J., Jack, T., Becker, B., Bischoff, B., Todt, D., Hodasa, V., Brill, F. H. H., Steinmann, E. and Steinmann, J.: Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid, BMC Infect. Dis. 16 (2016). PMid:26864562; DOI:10.1186/s12879-016-1410-9 Search in Google Scholar

52 Uzuner, H., Karadenizli, A., Er, D. K. and Osmani, A.: Investigation of the efficacy of alcohol-based solutions on adenovirus serotypes 8, 19 and 37, common causes of epidemic keratoconjunctivitis, after an adenovirus outbreak in hospital, J. Hosp. Infect. 100 (2018) e30–e36. PMid:29792970; DOI:10.1016/j.jhin.2018.05.011 Search in Google Scholar

53 Reichel, M., Heisig, P., Kohlmann, T. and Kampf, G.: Alcohols for skin antisepsis at clinically relevant skin sites, Antimicrob. Agents Chemother. 53 (2009) 4778–4782. PMid:19738017; DOI:10.1128/AAC.00582-09 Search in Google Scholar

54 Liu, P., Yuen, Y., Hsiao, H. M., Jaykus, L. A. and Moe, C.: Effectiveness of liquid soap and hand sanitizer against Norwalk virus on contaminated hands, Appl. Environ. Microbiol. 76 (2010) 394–399. PMid:19933337; DOI:10.1128/AEM.01729-09 Search in Google Scholar

55 Mahmood, A., Eqan, M., Pervez, S., Alghamdi, H. A., Tabinda, A. B., Yasar, A. Brindhadevi, K. and Pugazhendhi, A.: COVID-19 and frequent use of hand sanitizers; human health and environmental hazards by exposure pathways, Sci. Total Environ. 742 (2020) 140561. PMid:32623176; DOI:10.1016/j.scitotenv.2020.140561 Search in Google Scholar

56 Miller, M. A., Rosin, A., Levsky, M. E., Patel, M. M., Gregory, T. J. D. and Crystal, C. S.: Does the clinical use of ethanol-based hand sanitizer elevate blood alcohol levels? A prospective study, Am. J. Emerg. Med. 24 (2006) 815–817. PMid:17098103; DOI:10.1016/j.ajem.2006.05.006 Search in Google Scholar

57 Santos, C., Kieszak, S., Wang, A., Law, R., Schier, J. and Wolkin, A.: Reported adverse health effects in children from ingestion of alcohol-based hand sanitizers – United States, 2011–2014 Morbidity and Mortality Weekly Report (MMWR), 2017. PMid:28253227; DOI:10.15585/mmwr.mm6608a5 Search in Google Scholar

58 Berning, C. K., Griffith, J. F. and Wild, J. E.: Research on the effectiveness of Denatonium Benzoate as a deterrent to liquid detergent ingestion by children, Fundam. Appl. Toxicol. 2 (1982) 44–48. DOI:10.1093/toxsci/2.1.44 Search in Google Scholar

59 Pulce, C. and Descotes, J.: Household products, in: Hum. Toxicol., Elsevier Science, 1996. DOI:10.1016/B978-044481557-6/50030-7 Search in Google Scholar

60 Richards, G. C.: Alcohol-based hand sanitisers: a warning to mitigate future poisonings and deaths, BMJ Evidence-Based Med. (2020). PMid:33262124; DOI:10.1136/bmjebm-2020-111568 Search in Google Scholar

61 Emami, A., Javanmardi, F., Keshavarzi, A. and Pirbonyeh, N.: Hidden threat lurking behind the alcohol sanitizers in COVID-19 outbreak, Dermatol. Ther. 33 (2020) 17–19. PMid:32436262; DOI:10.1111/dth.13627 Search in Google Scholar

62 Bondurant, S., McKinney, T., Bondurant, L. and Fitzpatrick, L.: Evaluation of a benzalkonium chloride hand sanitizer in reducing transient Staphylococcus aureus bacterial skin contamination in health care workers, Am. J. Infect. Control. 48 (2020) 522–526. PMid:31668935; DOI:10.1016/j.ajic.2019.08.030 Search in Google Scholar

63 Tvedt, C. and Bukholm, G.: Alcohol-based hand disinfection: A more robust hand-hygiene method in an intensive care unit, J. Hosp. Infect. 59 (2005) 229–234. PMid:15694980; DOI:10.1016/j.jhin.2004.10.003 Search in Google Scholar

64 Poon, W. C. K., Brown, A. T., Direito, S. O. L., Hodgson, D. J. M., Le Nagard, L., Lips, A., MacPhee, C. E., Marenduzzo, D., Royer, J. R., Silva, A. F., Thijssen, J. H. J. and Titmuss, S.: Soft matter science and the COVID-19 pandemic Wilson, Soft Matter. (2020). PMid:32909024; DOI:10.1039/D0SM01223H Search in Google Scholar

65 Nussinovitch, A.: Gum technology in the food and other industries, First, Chapman & Hall, 1997. DOI:10.1007/978-1-4615-6385-3 Search in Google Scholar

66 Song, X., Vossebein, L. and Zille, A.: Efficacy of disinfectant-impregnated wipes used for surface disinfection in hospitals?: a review, Antimicrob. Resist. Infect. Control. 8 (2019) 139. PMid:31452873; DOI:10.1186/s13756-019-0595-2 Search in Google Scholar

67 Heisig, C. C. and Kaiser, N.-H. E.: Non-aerosol foaming alcohol hand sanitizer, US 2013/0090380 A1, 2013. Search in Google Scholar

68 Khan, N. and Faisal, S.: Epidemiology of corona virus in the world and its effects on the China economy, SSRN Electron. J. (2020) 2–4. DOI:10.2139/ssrn.3548292 Search in Google Scholar

69 Gold, N. A. and Avva, U.: Alcohol sanitizer, in: StatePearls NCBI Bookshelf, StatPearls Publishing LLC, 2020. https://www.ncbi.nlm.nih.gov/books/NBK513254/?report=printable Search in Google Scholar

70 Fini, M. B.: What dentists need to know about COVID-19, Oral Oncol. (2020) 104741. PMid:32380453; DOI:10.1016/j.oraloncology.2020.104741 Search in Google Scholar

71 Mondal, S. and Kolhapure, S. A.: Evaluation of the antimicrobial efficacy and safety of PureHands herbal hand sanitizer in hand hygiene and on inanimate objects, Antiseptic. 101 (2004) 55–57. Search in Google Scholar

72 Jing, J. L. J., Yi, T. P., Bose, R. J. C., Mccarthy, J. R., Tharmalingam, N. and Madheswaran, T.: Hand sanitizers?: a review on formulation aspects, adverse effects, and regulations, Int. J. Environ. Res. Public Heal. Rev. 17 (2020). PMid:32403261; DOI:10.3390/ijerph17093326 Search in Google Scholar

73 Foddai, A. C. G., Grant, I. R. and Dean, M.: Efficacy of instant hand sanitizers against foodborne pathogens compared with hand washing with soap and water in food preparation settings?: a systematic review, J. Food Prot. 79 (2016) 1040–1054. PMid:27296611; DOI:10.4315/0362-028X.JFP-15-492 Search in Google Scholar

74 Daga, M. K., Kumar, N., Aarthi, J., Mawari, G., Garg, S. and Rohatgi, I.: From SARS-CoV to coronavirus disease 2019 (COVID-19) – a brief review, J. Adv. Res. Med. 6 (2019) 1–9. DOI:10.24321/2349.7181.201917 Search in Google Scholar

75 Chakraborty, I. and Maity, P.: COVID-19 outbreak: migration, effects on society, global environment and prevention, Sci. Total Environ. 728 (2020) 138882. PMid:32335410; DOI:10.1016/j.scitotenv.2020.138882 Search in Google Scholar

76 Ahmed, M. A., Jouhar, R., Ahmed, N., Adnan, S., Aftab, M., Zafar, M. S. and Khurshid, Z.: Fear and practice modifications among dentists to combat novel coronavirus disease (COVID-19) outbreak, Int. J. Environ. Res. Public Heal. Artic. 17 (2020). PMid:32325888; DOI:10.3390/ijerph17082821 Search in Google Scholar

77 Marwah, A. K. and Marwah, P.: Coronavirus (COVID-19): a protocol for prevention, treatment and control, J. Appl. Nat. Sci. 12 (2020) 119–123. jans.-v12i2.2269. DOI:10.31018/ Search in Google Scholar

78 Berardi, A., Perinelli, D. R., Merchant, H. A., Bisharat, L., Basheti, I. A., Bonacucina, G., Cespi, M. and Palmieri, G. F.: Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand, Int. J. Pharm. 584 (2020) 119431. PMid:32461194; DOI:10.1016/j.ijpharm.2020.119431 Search in Google Scholar

79 Lunn, P. D., Belton, C. A., Lavin, C., McGowan, F. P., Timmons, S. and Robertson, D. A.: Using behavioural science to help fight the coronavirus: a rapid, narrative review, J. Behav. Public Adm. 3 (2020). DOI:10.30636/jbpa.31.147 Search in Google Scholar

80 Garfin, D. R., Silver, R. C. and Holman, E. A.: The novel coronavirus (COVID-2019) outbreak: amplification of public health consequences by media exposure, Heal. Psychol. (2020). PMid:32202824; DOI:10.1037/hea0000875 Search in Google Scholar

81 Amgain, K., Neupane, S., Panthi, L. and Thapaliya, P.: Myths versus truths regarding the novel coronavirus disease (COVID-2019) outbreak, J. Karnali Acad. Heal. Sci. 3 (2020) 1–6. DOI:10.3126/jkahs.v3i1.28367 Search in Google Scholar

82 Huh, S.: How to train health personnel to protect themselves from SARS-CoV-2 (novel coronavirus) infection when caring for a patient or suspected case, J. Educ. Eval. Health Prof. 17 (2020). PMid:32150796; DOI:10.3352/jeehp.2020.17.10 Search in Google Scholar

83 Eggers, M., Eickmann, M. and Zorn, J.: Rapid and effective virucidal activity of povidone-iodine products against middle east respiratory syndrome corona-virus (MERS-CoV) and modified vaccinia virus ankara (MVA), Infect. Dis. Ther. 4 (2015) 491–501. PMid:26416214; DOI:10.1007/s40121-015-0091-9 Search in Google Scholar

84 Rutala, W. A. and Weber, D. J.: Disinfection of endoscopes: review of new chemical sterilants used for high-level disinfection, Infect. Control Hosp. Epidemiol. 20 (1999) 69–76. PMid:9927274; DOI:10.1086/501544 Search in Google Scholar

85 Monticello, M. W.: Hydrogen peroxide composition, 5,376,387, 1994. Search in Google Scholar

86 Coates, D.: An evaluation of the use of chlorine dioxide (Tristel One-Shot) in an automated washer/disinfector (Medivator) fitted with a chlorine dioxide generator for decontamination of flexible endoscopes, J. Hosp. Infect. 48 (2001) 55–65. PMid:11358471; DOI:10.1053/jhin.2001.0956 Search in Google Scholar

87 Ley, C., Sundaram, V., de la Luz Sanchez, M., Desai, M. and Parsonnet, J.: Triclosan and triclocarban exposure, infectious disease symptoms and antibiotic prescription in infants–a community-based randomized intervention, PLoS One. 13 (2018) 1–14. PMid:29953463; DOI:10.1371/journal.pone.0199298 Search in Google Scholar

88 Onsoyen, E.: Alginates, in: Thickening and gelling Agents for Food, Chapman & Hall 1997, 1997: p. 22. DOI:10.1007/978-1-4615-2197-6_2 Search in Google Scholar

89 Bampidis, V., Azimonti, G., Bastos, M. de L., Christensen, H., Dusemund, B., Kos Durjava, M., Kouba, M. López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Bories, G., Gropp, J., Nebbia, C., Innocenti, M.L. and Aquilina, G.: Safety and efficacy of sodium carboxymethyl cellulose for all animal species, EFSA J. 18 (2020). PMid:32760467; DOI:10.2903/j.efsa.2020.6211 Search in Google Scholar

90 Namikoshi, H. and Ohmiya, T.: Quarternary ammonium salts of carboxymethylcellulose, 4,617,385, 1986. Search in Google Scholar

Received: 2020-09-28
Accepted: 2021-04-14
Published Online: 2021-11-30

© 2021 Walter de Gruyter GmbH, Berlin/Boston, Germany