Accessible Requires Authentication Published by De Gruyter September 25, 2021

Weakening of the Transdermal Effect of p-Phenylenediamine Pigments by the Temperature-Sensitive Poloxamer Sodium Alginate Gel

Schwächung der transdermalen Wirkung von p-Phenylendiamin-Pigmenten durch das temperatursensitive Poloxamer-Natriumalginat-Gel
Haiyan Gao, Yue Zhou, Jianguo Wang and Hujun Xu


A temperature-sensitive hair dye was prepared with a poloxamer-sodium alginate mixture. When the hair dye was applied to the hair (< 32 °C), it retained its flow dynamics. The hair dye was able to undergo a phase change and formed a solid as soon as it touched the scalp (32°C), which reduced the transdermal amount of p-phenylenediamine (PPD) and also adverse effects and toxicity. Compared to a conventional hair dye, the temperature-sensitive hair dye achieved a reduction of the transdermal amount of p-phenylenediamine by almost 65% at different concentrations. At the same time, the colouring effect was not significantly reduced. The poloxamer alginate hydrogel can be used as a novel colouring material to reduce the harm of the dye intermediate to the human body when colouring hair.


Es wurde ein temperaturempfindliches Haarfärbemittel mit einer Poloxamer-Natriumalginat-Mischung hergestellt. Beim Auftragen des Haarfarbstoffs auf das Haar (< 32°C), behielt er seine Fließdynamik. Der Haarfarbstoff war in der Lage, einen Phasenwechsel zu vollziehen und bildete einen Feststoff, sobald er die Kopfhaut (32°C) berührte, was die transdermale Menge an p-Phenylendiamin (PPD) reduzierte und die Nebenwirkungen und Toxizität verringerten. Im Vergleich zu einem konventionellen Haarfärbemittel reduzierte das temperaturempfindliche Haarfärbemittel die transdermale Menge an p-Phenylendiamin bei verschiedenen Konzentrationen um fast 65%. Gleichzeitig wurde die Färbewirkung nicht signifikant reduziert. Das Poloxamer-Alginat-Hydrogel kann als neuartiges Färbematerial verwendet werden, um den Schaden des Farbstoff-Zwischenprodukts für den menschlichen Körper beim Färben der Haare zu reduzieren.

Mrs. Haiyan Gao School of Chemical and Material Engineering Jiangnan University Wuxi Jiangsu P. R. China Telephone: +86 13382888939
Prof. Dr. Hujun Xu School of Chemical & Material Engineering Jiangnan University Wuxi China E-mail:


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Received: 2020-12-11
Accepted: 2021-04-14
Published Online: 2021-09-25
Published in Print: 2021-09-30

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