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The synthesis of new nucleosides by alkenylation of 5-iodo-2’-halo-2’-deoxyuridines with E-(1-tributylstannyl)-propene-1-ol via STILLE-coupling is described. The new compounds are characterized by 1H NMR and elemental analysis. All nucleosides are evaluated by an enzymatic assay to be substrates of herpes simplex virus type 1 thymidine kinase (HSV-1 TK) and compared with uridine, thymidine and (E)-5-(2-iodovinyl)-2’-fluoro-2’-deoxyuridine (IVFRU).
Received: 2002-4-24
Published Online: 2014-6-2
Published in Print: 2003-3-1
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