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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Synthesis of Decaline Analogues of Isovelleral

  • M. Johansson , I. Aujard , D. Röme , H. Anke and O. Sterner EMAIL logo

Decaline analogues of the bioactive fungal sesquiterpene (+)-isovelleral (1a), retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system, were prepared, and their cytotoxic and antimicrobial activities were compared with those of the natural product. While the two isomers (±)-2 and (±)-3 were as active as isovelleral (1a), the isomer (±)-4 was approximately 10 times less potent.

Received: 2005-5-19
Published Online: 2014-6-2
Published in Print: 2005-9-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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