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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Synthesis of Novel Macrocyclic Peptido-calix[4]arenes and Peptidopyridines as Precursors for Potential Molecular Metallacages, Chemosensors and Biologically Active Candidates

  • Abd El-Galil El-Sayed Amr EMAIL logo , Mohamed Abo-Ghalia and Mohamed M. Abdalah
From the journal Zeitschrift für Naturforschung B
https://doi.org/10.1515/znb-2006-1104
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Novel macrocyclic dipicolinic acid acylated peptides based on upper rim bridged peptidocalix[ 4]arenes, peptido-pyridines or hybrid structures of both, were synthesized as potential molecular metallacages and chemosensors. While conventional azide or mixed anhydride (ethyl chloroformate) peptide couplings served well for assembling the L-tyrosine or L-ornithine peptide backbones, the acid chloride of pyridine-2,6-dicarboxylic acid (dipicolinic acid) acid served as the complementary acylating agent. The structure assignment of the new compounds was based on chemical and spectroscopic evidences. Some of these compounds exhibit antimicrobial activities.

Keywords: Pyridine-2,6-bisamino Acid; Chiral Macrocycles; Peptido-calix[4]arenes; Antimicrobial Agents
Received: 2006-3-15
Published Online: 2014-6-2
Published in Print: 2006-11-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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From the journal
Zeitschrift für Naturforschung B
Zeitschrift für Naturforschung B
Volume 61 Issue 11

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