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Licensed Unlicensed Requires Authentication Published by De Gruyter June 17, 2021

A new N-oxide benzylisoquinoline alkaloid isolated from the leaves of atemoya (Annona cherimola × Annona squamosa)

Suzana V. Rabêlo , Edigênia C. C. Araújo , Emmanoel V. Costa , Raimundo Braz-Filho , Andersson Barison , Maria de F. C. Santos , Gibson G. Oliveira , José C. Tomaz , Larissa A. Rolim , Norberto P. Lopes , Maria F. S. Silva , Manoel O. Moraes , Cláudia do Ó Pessoa , Noureddine El Aouad and Jackson R. G. S. Almeida EMAIL logo

Abstract

Phytochemical investigation of the atemoya aerial parts was carried out by LC-MS-IT and cytotoxic activities were evaluated as well. These results led to the identification of a new N-oxide alkaloid (dehydroanomuricine-N-oxide) and eight other alkaloids: scoulerine, reticuline, isocorydine, norisocorydine, asimilobine, nornuciferine, anonaine, and liriodenine. The new alkaloid dehydroanomuricine-N-oxide and anomuricine were also isolated. The structures of these compounds were determined by spectroscopic and spectrometric techniques. The cytotoxic capacity of crude methanolic extract and the alkaloidal fraction were evaluated, showing moderate cytotoxicity. The isolation and identification of these alkaloids are an important contribution to the chemotaxonomy of the genus Annona and the Annonaceae family.


Corresponding author: Jackson R. G. S. Almeida, Center for Studies and Research of Medicinal Plants (NEPLAME), Federal University of San Francisco Valley, CEP 56.304-205, Petrolina, Pernambuco, Brazil; and Post-Graduate Program in Biotechnology (RENORBIO), Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil, E-mail:

Funding source: CNPq

Award Identifier / Grant number: 470594/2013-6

Award Identifier / Grant number: 442209/2014-2

Award Identifier / Grant number: 303587/2014-8

Funding source: CAPES

Funding source: FACEPE

Funding source: USP

Funding source: UENF

Funding source: UFPR

Funding source: UFAM

Funding source: UNIVASF

Acknowledgments

The authors wish to express their thanks to Centro de Referência para Recuperação de Áreas Degradadas (CRAD) for botanical identification of the plant material.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The authors are grateful to CNPq (Processes: 470594/2013-6, 442209/2014-2, and 303587/2014-8), CAPES, FACEPE, USP, UENF, UFPR, UFAM, and UNIVASF for financial support, fellowships, and collaboration.

  3. Conflict of interest statement: The authors declare that there are no conflicts of interests and they affirm that this paper consists of original and unpublished work.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/znb-2020-0187).


Received: 2020-11-18
Accepted: 2021-05-14
Published Online: 2021-06-17
Published in Print: 2021-07-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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