Tropoyl coenzyme A has been synthesized in good yields via the corresponding N-hydroxysuc-cinimide ester. The UV-spectrum of the purified thioester has an absorption maximum at 257 nm; at this wavelength, a molar extinction coefficient of 19.2 × 106 [cm2 mol-1] has been determined. Upon alkaline hydrolysis of the thioester bond a difference spectrum with Amax at 235 nm (Δe235= 4.8 × 106 [cm2 mol-1]) has been observed. Attempts to prepare 2-phenylmalonyl coenzyme A by the same technique gave negative results.
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