Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Chemical Synthesis of Tropoyl Coenzyme A

Georg G. Gross and Karl J. Koelen


Tropoyl coenzyme A has been synthesized in good yields via the corresponding N-hydroxysuc-cinimide ester. The UV-spectrum of the purified thioester has an absorption maximum at 257 nm; at this wavelength, a molar extinction coefficient of 19.2 × 106 [cm2 mol-1] has been determined. Upon alkaline hydrolysis of the thioester bond a difference spectrum with Amax at 235 nm (Δe235= 4.8 × 106 [cm2 mol-1]) has been observed. Attempts to prepare 2-phenylmalonyl coenzyme A by the same technique gave negative results.

Received: 1980-3-10
Published Online: 2014-6-2
Published in Print: 1980-6-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Scroll Up Arrow