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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

4-Epidihydrocochlioquinone B and 14-Epicochlioqumone B, Antibiotics from Fermentations of the Ascomycete Neobulgaria pura: Structure Elucidation and Effects on Platelet Aggregation

Kirsten Lorenzen , Timm Anke , Uwe Anders , Hermann Hindermayr and Fritz Hansske

Abstract

14-Epicochlioquinone B (1) and 14-epidihydrocochlioquinone B (2) were isolated from sub­ merged cultures of Neobulgaria pura (Pers. ex Fr.) Petrak. 14-Epicochlioquinone B is a potent inhibitor of hum an and bovine platelet aggregation stimulated by different inducers. 14-Epidihydrocochlioquinone B does not inhibit the aggregation of platelets. In addition, both 1 and 2 exhibited cytotoxic and antimicrobial activites.

Received: 1993-9-9
Revised: 1994-1-26
Published Online: 2014-6-2
Published in Print: 1994-6-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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