An Antiviral Meliacarpin from Leaves of Melia azedarach L.

Laura E. Alché; Guillermo Assad Ferek; Milena Meo; Celia E. Coto; Marta S. Maier

doi:10.1515/znc-2003-3-413

Open Access Published by De Gruyter June 2, 2014

An Antiviral Meliacarpin from Leaves of Melia azedarach L.

Laura E. Alché , Guillermo Assad Ferek , Milena Meo , Celia E. Coto and Marta S. Maier

From the journal Zeitschrift für Naturforschung C

https://doi.org/10.1515/znc-2003-3-413

Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC₅₀ values of 6 μᴍ and 20 μᴍ for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.

Keywords : Melia azedarach L.; Limonoids; Antiviral Activity

Received: 2002-10-21

Revised: 2002-11-18

Published Online: 2014-6-2

Published in Print: 2003-4-1

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

An Antiviral Meliacarpin from Leaves of Melia azedarach L.

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