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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

An Antiviral Meliacarpin from Leaves of Melia azedarach L.

  • Laura E. Alché , Guillermo Assad Ferek , Milena Meo , Celia E. Coto and Marta S. Maier EMAIL logo

Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 μᴍ and 20 μᴍ for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.

Received: 2002-10-21
Revised: 2002-11-18
Published Online: 2014-6-2
Published in Print: 2003-4-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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