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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Diosgenin Glucuronides from Solanum lyratum and their Cytotoxicity against Tumor Cell Lines

Li-Xin Sun, Wen-Wei Fu, Wen Li, Kai-Shun Bi and Min-Wei Wang

Bioassay-directed fractionation of the cytotoxicity active fraction of the whole plant from Solanum lyratum led to the isolation of a new steroidal saponin, diosgenin 3-O-β-ᴅ-glucopyranosiduronic acid methyl ester (2), as well as four known compounds, diosgenin (1), diosgenin 3-O-β-ᴅ-glucopyranosiduronic acid (3), diosgenin 3-O-α-ʟ-rhamnopyranosyl-(1→2)-β-ᴅ-glucopyranosiduronic acid (4), diosgenin 3-O-α-ʟ-rhamnopyranosyl-(1→2)-β-ᴅ-glucuroniduronic acid methyl ester (5). The structures of the isolated compounds were elucidated on the basis of their spectral data and chemical evidences. Compound 1 was isolated for the first time from this plant, and compound 3 was isolated as a new natural product. Cytotoxic activities of the isolated compounds were evaluated and the cytotoxicities of compounds 2-5 reported for the first time.

Received: 2005-7-18
Revised: 2005-9-7
Published Online: 2014-6-2
Published in Print: 2006-4-1

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