The variability of sorbicillin derivatives production by marine Trichoderma sp., isolated from the sponge Agelas dispar J., was studied using six different culture media to find a good medium for biomass production, particularly of trichodimerol, bislongiquinolide and bisvertinol. A simple and rapid convenient method for identification, quantification and validation of the sorbicillin derivatives in ethyl acetate extracts has been applied by using RPHPLC coupled with diode array detection.
Received: 2007-11-27
Revised: 2008-2-27
Published Online: 2014-6-2
Published in Print: 2008-10-1
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