Antifungal and Antibacterial Activities of Pentanema divaricatum and Its Active Constituent

Nastaran Momen-Roknabadi; Ahamd R. Gohari; Hamid R. Monsef-Esfehani; Farideh Attar; Reza Hajiaghaee; Soodabeh Saeidnia; Hossein Jamalifar; Golnaz Kamalinia; Ahamd R. Shahverdi

doi:10.1515/znc-2008-9-1006

Open Access Published by De Gruyter June 2, 2014

Antifungal and Antibacterial Activities of Pentanema divaricatum and Its Active Constituent

Nastaran Momen-Roknabadi , Ahamd R. Gohari , Hamid R. Monsef-Esfehani , Farideh Attar , Reza Hajiaghaee , Soodabeh Saeidnia , Hossein Jamalifar , Golnaz Kamalinia and Ahamd R. Shahverdi

From the journal Zeitschrift für Naturforschung C

https://doi.org/10.1515/znc-2008-9-1006

The antimicrobial activity of ethanol and chloroform extracts of Pentanema divaricatum Cass. was studied using the conventional disk diffusion method. The extracts’ highest antimicrobial activity was observed against Aspergillus niger. Bioassay-guided fractionation of the crude extract by preparative thin layer chromatography (PTLC) showed one antimicrobial fraction which was especially effective against Aspergillus niger. By conventional spectroscopy the active fraction was identified as 4α,5α-epoxy-10α,14H-1-epi-inuviscolide. This compound represented the most potent antimicrobial candidate, with MIC values of < 25 μg/disk against A. niger strains and 200 μg/disk against Bacillus cereus and Staphylococcus aureus.

Keywords : Antimicrobial; Inuviscolide Derivative; Pentanema divaricatum

Received: 2008-3-12

Published Online: 2014-6-2

Published in Print: 2008-10-1

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antifungal and Antibacterial Activities of Pentanema divaricatum and Its Active Constituent

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