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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Production of Recombinant Human Granulocyte Macrophage Colony- Stimulating Factor from Silkworm Bombyx mori Bm5 Cells

  • Cho-Yi Jin , Song-Yi Han , Kisang Kwon , Eun Young Yun , Seok Woo Kang , Tae Won Goo , Seung-Whan Kim , Kweon Yu and O-Yu Kwon EMAIL logo

Using silkworm Bombyx mori Bm5 cells, we established a stable cell line expressing the human granulocyte macrophage colony-stimulating factor (hGM-CSF), which gets its name from the Bm5-hGM-CSF cell in which the glycoprotein of the hGM-CSF is secreted in the cell culture supernatant (CCS). It was demonstrated that secreted hGM-CSF had in vivo biological activity and the white blood cell (WBC) value increased two times that of the control. We expect to produce useful human recombinant glycoproteins from silkworm cultured cells for a low price and a large quantity

Received: 2009-7-29
Revised: 2009-8-26
Published Online: 2014-6-2
Published in Print: 2010-2-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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