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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Evaluation of the Anti-Inflammatory and Antinociceptive Properties of p-Cymene in Mice

Leonardo R. Bonjardim, Edisleide S. Cunha, Adriana G. Guimarães, Michele F. Santana, Makson G. B. Oliveira, Mairim R. Serafini, Adriano A. S. Araújo, Ângelo R. Antoniolli, Sócrates C. H. Cavalcanti, Márcio R. V. Santos and Lucindo J. Quintans-Júnior

We attempted to identify the antinociceptive and anti-inflammatory actions of the monoterpene p-cymene. Firstly, behavioural screening was carried out to verify the influence of p-cymene [25, 50, and 100 mg/kg intraperitoneal (i.p.)] on the central nervous system (CNS) activity. The antinociceptive activity of p-cymene was evaluated by the acetic acidinduced writhing response, formalin, and hot-plate test, respectively. The leukocyte migration induced by injection of carrageenan was used to assess the anti-inflammatory activity. p-Cymene showed depressant activity on CNS after 4 h of treatment and also a possible action on the autonomous nervous system (ANS), mainly at the dose of 100 mg/kg (i.p.). It was found that p-cymene (50 and 100 mg/kg, i.p.) significantly (p < 0.05) reduced the writhing responses induced by acetic acid. p-Cymene also decreased the licking time in the first and second phase, respectively, of the formalin test. The results of the hot-plate test showed that all doses of p-cymene increased significantly the latency time of the response to the thermal stimulus in both licking and jumping parameters. In addition, there was a significantly (p < 0.05) decreased leukocyte migration at all doses of p-cymene. The experimental data demonstrate that p-cymene possesses antinociceptive and anti-inflammatory activities

Received: 2011-3-11
Revised: 2011-11-21
Published Online: 2014-6-2
Published in Print: 2012-2-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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