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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Antitumour Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica

Yong Li , Zhi-Yu Ni , Meng-Chu Zhu , Mei Dong , Si-Ming Wang , Qing-Wen Shi EMAIL logo , Man-Li Zhang , Yu-Fang Wang , Chang-hong Huo , Hiromasa Kiyota and Bin Cong

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Eight sesquiterpene lactones were isolated from the roots of Inula helenium and fl owers of I. japonica. Among them, isoalantolactone () and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 ≤ 100 μM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an α-exomethylene- γ-lactone ring is necessary for these activities.

Received: 2011-3-22
Revised: 2011-12-27
Published Online: 2014-6-2
Published in Print: 2012-8-1

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