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Publicly Available Published by De Gruyter June 2, 2014

Analgesic and Anticonvulsant Activities of Some Newly Synthesized Trisubstituted Pyridine Derivatives

  • Osama I. Abdel Salam , Mohamed A. Al-Omar , Nagy M. Khalifa , Abd El-Galil E. Amr EMAIL logo and Mohamed M. Abdallah

A series of novel pyridine carbohydrazide derivatives were synthesized from the reaction of 2-chloro-6-hydrazino-isonicotinic acid hydrazide with selected active reagents. All prepared compounds were tested as analgesic and anticonvulsant agents. The pharmacological screening showed that many of these compounds have good activities comparable to those of valdecoxib and carbamazepine as reference drugs

Received: 2012-7-20
Revised: 2013-6-14
Published Online: 2014-6-2
Published in Print: 2013-8-1

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