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Licensed Unlicensed Requires Authentication Published by De Gruyter January 10, 2018

Antimicrobial and antioxidant activities of two polyketides from lichen-endophytic fungus Preussia sp.

  • Babita Paudel , Keshab Bhattarai and Hari Datta Bhattarai EMAIL logo


Two compounds, compounds 1 and 2, were isolated from Preussia sp. The molecular structures of both compounds were elucidated by analyzing one-dimensional (1D) and 2D nuclear magnetic resonance data along with high-resolution mass spectrometry data. Compound 1 was obtained as novel in structure, and compound 2 was recently reported elsewhere. Compound 1 did not show antioxidant and antimicrobial activities and brine shrimp toxicity, while compound 2 showed strong antioxidant activity (DPPH reduction capacity; IC50=3 μg/mL) and brine shrimp toxicity (LD50=50 μg/mL).


The research was supported by the International Science Foundation (grant no. F5476-1F& 2F) to Dr. Babita Paudel-Bhattarai. Similarly, B. Paudel and H. D. Bhattarai acknowledge the Alexander von Humboldt Foundation for the instrument grant.


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Supplemental Material:

The online version of this article offers supplementary material (

Received: 2017-6-7
Revised: 2017-10-29
Accepted: 2017-11-30
Published Online: 2018-1-10
Published in Print: 2018-2-23

©2018 Walter de Gruyter GmbH, Berlin/Boston

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