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Evaluation of Lavandula stoechas L. subsp. stoechas L., Mentha spicata L. subsp. spicata L. essential oils and their main components against sinusitis pathogens

Nursenem Karaca , Betül Demirci and Fatih Demirci EMAIL logo


Lavandula stoechas subsp. stoechas and Mentha spicata subsp. spicata are used for the treatment of sinusitis in Turkish folk medicine. The components of essential oils obtained by hydrodistillation were determined by gas chromatography-flame ionization detector (GC-FID), gas chromatography/mass spectrometry (GC/MS), and thin layer chromatography (TLC). Major components of L. stoechas and M. spicata oils were determined as camphor (46.7%) and carvone (60.6%), respectively. The antibacterial activity of essential oils and their main components were tested against the common selected sinusitis pathogens Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, and Pseudomonas aeruginosa using in vitro agar diffusion, microdilution, and vapor diffusion methods. As a result, the tested plant materials, which are locally and natively used against sinusitis, were relatively mild antibacterial (in vitro MICs 310–1250 μg/mL) in action. To use essential oils and their components safely in sinusitis therapy, further detailed in vivo experiments are needed to support their efficacy.


This work was supported by the Anadolu University Scientific Research Projects (BAP 1309S319), which is a part of the MSc work of N. Karaca. The authors would like to thank for the identification of the plant material by Prof. Dr. Yavuz Bülent KÖSE of the Pharmaceutical Botany Department.


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Supplementary Material

The online version of this article offers supplementary material (

Received: 2017-08-22
Revised: 2017-12-15
Accepted: 2018-01-10
Published Online: 2018-02-27
Published in Print: 2018-09-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

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