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Licensed Unlicensed Requires Authentication Published by De Gruyter February 7, 2020

Comparative studies of the biological activities of selected herbal extracts and phenolic compounds isolated from Rosa gallica

Atsumi Shimada, Hiroshi Ueno, Masanori Inagaki and Hitoshi Yoshimitsu


This study aimed to compare the biological activities of 35 herbal hydroethanolic extracts and select high potential extract, which showed antioxidative activity and inhibitory activities of α-glucosidase, lipase, and hyaluronidase, and to investigate the isolation, structural elucidation, and biological activities of five phenolic compounds from the selected extracts of Rosa gallica. On the basis of one-dimensional nuclear magnetic resonance together with the comparison with the literature values, the phenolic compounds were identified as methyl gallate (1), kaempferol-3-O-arabinofuranoside (2), multinoside A acetate (3), kaempferol (4), and quercetin (5), respectively. The results suggest that the extracts from R. gallica show the strongest biological activities in 35 herbal extracts and that 1, 4, and 5 among the five isolated compounds from rose extracts are effective in promoting antioxidative and enzymatic inhibitory activities.

  1. Funding sources: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

  2. Conflicts of interest: The authors state no conflict of interest.


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Received: 2019-06-18
Revised: 2019-07-31
Accepted: 2019-09-18
Published Online: 2020-02-07
Published in Print: 2020-01-28

©2020 Walter de Gruyter GmbH, Berlin/Boston

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