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Licensed Unlicensed Requires Authentication Published by De Gruyter May 18, 2021

Flavonolignan 2, 3-dehydroderivatives from Oenanthe javanica and their anti inflammatory activities

Rong-Rui Wei ORCID logo and Qin-Ge Ma ORCID logo

Abstract

Flavonolignans, for example, silymarin and silybin, have interesting biological activities. For the first time, three new flavonolignans named oenanthenoid A-C (13) and nine known flavonolignan derivatives (412) were isolated from Oenanthe javanica. Comprehensive spectroscopic data analysis and references were used to identify all of the compounds. The anti inflammatory activities of these isolates (112) on RAW264.7 macrophage cells were investigated. Three new compounds (13) demonstrated anti inflammatory activity with IC50 values ranging from 6.5 ± 0.6 to 14.7 ± 1.6 µM. Furthermore, two compounds (11 and 12) demonstrated moderate anti inflammatory activity, with IC50 values ranging from 24.1 ± 1.2 to 62.5 ± 1.9 µM.


Corresponding author: Qin-Ge Ma, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine & Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, P. R. China, E-mail:

Funding source: Science and Technology Project of Jiangxi Administration of Traditional Chinese Medicine

Award Identifier / Grant number: 2019A002

Funding source: Jiangxi Provincial Natural Science Foundation

Award Identifier / Grant number: 20202BAB216036

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by Jiangxi Provincial Natural Science Foundation (20202BAB216036) and Science and Technology Project of Jiangxi Administration of Traditional Chinese Medicine (2019A002).

  3. Conflict of interest statement: The authors declare that they have no conflict of interest.

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Received: 2021-01-01
Accepted: 2021-05-02
Published Online: 2021-05-18
Published in Print: 2021-11-25

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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