A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2–5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).
This research was supported by The Youth Incubator for Science and Technology Programe, managed by Youth Development Science and Technology Center – Ho Chi Minh Communist Youth Union and Department of Science and Technology of Ho Chi Minh City, the contract number is 30/2019/HĐ-KHCN-VƯ.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: No potential conflict of interest was reported by the authors.
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Copies of spectroscopic data and HPLC chromatogram for 1 (Figures S1–S11).
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2021-0096).
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