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Licensed Unlicensed Requires Authentication Published by De Gruyter November 18, 2021

A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

  • Truong Nhat Van Do ORCID logo , Hai Xuan Nguyen ORCID logo , Tho Huu Le ORCID logo , Phu Hoang Dang ORCID logo , Mai Thanh Nguyen , Mai Thanh Thi Nguyen and Nhan Trung Nguyen EMAIL logo


A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (25). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).

Corresponding author: Nhan Trung Nguyen, Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam; Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam; and Vietnam National University, Ho Chi Minh City, Vietnam, E-mail:


This research was supported by The Youth Incubator for Science and Technology Programe, managed by Youth Development Science and Technology Center – Ho Chi Minh Communist Youth Union and Department of Science and Technology of Ho Chi Minh City, the contract number is 30/2019/HĐ-KHCN-VƯ.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: No potential conflict of interest was reported by the authors.


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Supplementary Material

Copies of spectroscopic data and HPLC chromatogram for 1 (Figures S1–S11).

The online version of this article offers supplementary material (

Received: 2021-04-03
Accepted: 2021-11-01
Published Online: 2021-11-18
Published in Print: 2022-05-25

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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