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Licensed Unlicensed Requires Authentication Published by De Gruyter September 19, 2022

Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil

  • Wan Mohd Nuzul Hakimi Wan Salleh ORCID logo EMAIL logo , Nurunajah Ab Ghani ORCID logo and Abu-Baker M. Abdel-Aal ORCID logo

Abstract

Essential oils obtained from medicinal plants show high therapeutic potential against several types of pathologies, including Alzheimer’s disease. The purpose of this work was to study the chemical composition and anticholinesterase inhibitory activity of the essential oil obtained from Lepisanthes rubiginosa leaves collected from Malaysia. Twenty-four components were identified using gas chromatography-flame ionization detection (GC-FID) and gas chromatography/mass spectrometry (GC-MS), which represent 99.5% of the essential oil. The identified major components include α-cadinol (40.0%), safrole (12.6%), α-amorphene (9.5%), (E)-isosafrole (5.0%), δ-cadinene (4.2%), and t-muurolol (4.1%). Anticholinesterase activity was assessed using Ellman method, and the essential oil demonstrated a moderate inhibitory activity against acetylcholinesterase (I%: 75.2%) and butyrylcholinesterase (I%: 70.2%) at conconcetration of 1000 μg/mL. The current study is the first to report chemical composition and anticholinesterase activity of the essential oil obtained from L. rubiginosa, which may have implications on the characterization, pharmaceutical, and therapeutic applications of Lepisanthes genus essential oils.


Corresponding author: Wan Mohd Nuzul Hakimi Wan Salleh, Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak, Malaysia, E-mail:

Funding source: Universiti Pendidikan Sultan Idris

Award Identifier / Grant number: Unassigned

Acknowledgments

The authors would like to thank the Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris for research facilities.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This study was funded by Universiti Pendidikan Sultan Idris.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-04-30
Accepted: 2022-08-31
Published Online: 2022-09-19
Published in Print: 2022-11-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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