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Licensed Unlicensed Requires Authentication Published by De Gruyter (O) August 26, 2016

SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

Andrey N. Pravdivtsev

Abstract

A strong limitation of nuclear magnetic resonance is its low inherent sensitivity that can be overcome by using an appropriate hyperpolarization technique. Presently, dynamic nuclear polarization and spin-exchange optical pumping are the only hyperpolarization techniques that are used in applied medicine. However, both are relatively complex in use and expensive. Here we present a modification of the signal amplification by reversible exchange (SABRE) hyperpolarization method – SABRE on stabilized Ir-complexes. A stabilized Ir-complex (here we used bipyridine for stabilization) can be hyperpolarized in a wide range of magnetic fields from a few μT upto 10 T with 15N polarization of about 1–3%. Moreover, the investigated complex can be incorporated into biomolecules or other bulky molecules; in this situation exchange with para-hydrogen will allow one to continuously generate hyperpolarization.


Dedicated to: Kev Salikhov on the occasion of his 80th birthday.


Acknowledgments

The author is thankful to Profs. Alexandra Yurkovskaya and Konstantin Ivanov for stimulating discussions. Low-field studies are supported by the Russian Foundation for Basic Research (Project no. 16-33-00679); high-field studies are supported by the Russian Science Foundation (Project no. 14-13-01053). FASO of Russia is acknowledged for providing access to NMR facilities (Project no. 0333-2014-0001). We acknowledge Dr. Pavel Petrov for providing us with the IrImesCODCl pre-catalyst.

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Supplemental Material:

The online version of this article (DOI: 10.1515/zpch-2016-0810) offers supplementary material, available to authorized users.


Received: 2016-6-6
Accepted: 2016-7-15
Published Online: 2016-8-26
Published in Print: 2017-3-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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