Zum Hauptinhalt springen
Lizenziert Nicht lizenziert Erfordert eine Authentifizierung Veröffentlicht von De Gruyter (O) 20. März 2019

Decomposition Kinetics of Levofloxacin: Drug-Excipient Interaction

  • Jan Nisar EMAIL logo , Mudassir Iqbal , Munawar Iqbal , Afzal Shah , Mohammad Salim Akhter , Sirajuddin , Rafaqat Ali Khan , Israr Uddin , Luqman Ali Shah und Muhammad Sufaid Khan

Abstract

The present study is focused on the thermal decomposition of Levofloxacin in the absence and presence of different excipients (sodium starch glycolate, magnesium stearate, microcrystalline cellulose and lactose using Thermogravimetry (TG). Fourier Transform Infra Red Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) were used to study the possible drug – excipient interaction. It has been shown that the interaction of the first three excipients (sodium starch glycolate, magnesium stearate, and microcrystalline cellulose) with Levofloxacin is physical in nature. Lactose was shown to decrease the degradation temperature to a maximum extent. This indicates a strong chemical interaction between the drug and lactose. The activation energies in the former case were found almost similar but deviated considerably in the latter case.

References

1. C. Fogarty, R. Goldschmidt, K. Bush, Clin. Infect. Dis. 31 (2000) 613.10.1086/313976Suche in Google Scholar PubMed

2. R. N. Greenberg, M. T. Newman, S. Shariaty, R. W. Pectol, Antimicrob. Agents Chemother. 44 (2000) 164.10.1128/AAC.44.1.164-166.2000Suche in Google Scholar PubMed PubMed Central

3. C. Urban, N. Rahman, X. Zhao, N. Mariano, S. Segal-Maurer, K. Drlica, J. J. Rahal, J. Infect. Dis. 184 (2001) 794.10.1086/323086Suche in Google Scholar PubMed

4. V. K. Shahwal, B. K. Dubey, M. Bhoumick, Int. J. Adv. Pharm. 1 (2012) 1.Suche in Google Scholar

5. M. A. Collado-Sánchez, M. Rambla-Alegre, S. Carda-Broch, Esteve-Romero Josep, J. Liq. Chromatogr. Relat. Technol. 33 (2010) 513.10.1080/10826070903574519Suche in Google Scholar

6. L. Pérez-Ibarbia, T. Majdanski, S. Schubert, N. Windhab, U. S. Schubert, Eur. J. Pharm. Sci. 93 (2016) 264.10.1016/j.ejps.2016.08.026Suche in Google Scholar PubMed

7. T. B. Ernest, D. P. Elder, L. G. Martini, M. Roberts, J. Pharm. Pharmacol. 59 (2007) 1043.10.1211/jpp.59.8.0001Suche in Google Scholar PubMed

8. M. J. Peres-Filho, M. P. N. Gaeti, S. R. Oliveira, R. N. Marreto, E. M. Lima, J. Therm. Anal. Calorim. 104 (2011) 255.10.1007/s10973-010-1245-3Suche in Google Scholar

9. H. K. Stulzer, P. O. Rodrigues, T. M. Cardoso, J. S. R. Matos, M. A. S. Silva, J. Therm. Anal. Calorim. 91 (2008) 323.10.1007/s10973-006-7935-1Suche in Google Scholar

10. K. P. Fu, S. C. Lafredo, B. Foleno, D. M. Isaacson, J. F. Barrett, A. J. Tobia, M. E. Rosenthale, Antimicrob. Agents Chemother. 36 (1992) 860.10.1128/AAC.36.4.860Suche in Google Scholar PubMed PubMed Central

11. M. A. Saleem, M. F. Nazar, B. Yameen, A. M. Khan, S. Z. Hussain, M. R. Khalid, Chemistry Select 3 (2018) 11616.Suche in Google Scholar

12. S. R. Baratam, J. Vijayaratna, Asian J. Pharm. Clin. Res. 11 (2018) 148.10.22159/ajpcr.2018.v11i6.20296Suche in Google Scholar

13. D. Asha, S. Jeganath, U. V. N. V. Arjun, S. Sathesh Kumar, Res. J. Pharm. Technol. 11 (2018) 1467.10.5958/0974-360X.2018.00273.1Suche in Google Scholar

14. V. D. Chavada, N. M. Bhatt, M. Sanyal, P. S. Shrivastav, Turk. J. Chem. 42 (2018) 36.10.3906/kim-1703-79Suche in Google Scholar

15. T. D. Nguyen, H. B. Le, T. O. Dong, T. D. Pham, J. Anal. Methods Chem. 2018 (2018) Article ID 8436948, 11.10.1155/2018/9462019Suche in Google Scholar PubMed PubMed Central

16. V. B. K. Mullapudi, K. Dheram, J. Food Drug Anal. 26 (2018) 385.10.1016/j.jfda.2016.09.001Suche in Google Scholar PubMed

17. Y. Chen, J. Wang, J. Liu, L. Lu, Z. Phys. Chem. 232 (2018) 1733.10.1515/zpch-2018-1145Suche in Google Scholar

18. D. Kaushal, D. S. Rana, M. Kumar, K. Singh, K. Singh, S. Chauhan, A. Umar, Z. Phys. Chem. 233 (2018) 413.10.1515/zpch-2017-1014Suche in Google Scholar

19. M. Imran, Z. Phys. Chem. 233 (2018) 273.10.1515/zpch-2017-1066Suche in Google Scholar

20. K. Roy, S. Saha, B. Datta, L. Sarkar, M. N. Roy, Z. Phys. Chem. 232 (2018) 281.10.1515/zpch-2017-0003Suche in Google Scholar

21. M. N. Roy, S. Barman, S. Saha, Z. Phys. Chem. 231 (2017) 1111.10.1515/zpch-2016-0804Suche in Google Scholar

22. E. A. Khramtsova, A. A. Ageeva, A. A. Stepanov, V. F. Plyusnin, T.V. Leshina, Z. Phys. Chem. 231 (2017) 609.10.1515/zpch-2016-0842Suche in Google Scholar

23. Y. Hu, J. Li, C.-W. Lv, D. Qu, Z. Hou, M. Jia, J.-T. Li, Z.-D. Zhang, X.-X. Luo, Z. Yuan, M.-K. Li, Z. Phys. Chem. 230 (2016) 97.10.1515/zpch-2015-0630Suche in Google Scholar

24. S. M. El-Megharbel, M. A. Hussien, M. S. Refat, J. Comput. Theor. Nanosci. 14 (2017) 561.10.1166/jctn.2017.6363Suche in Google Scholar

25. S. A. Sadeek, W. H. El-Shwiniy, J. Iran. Chem. Soc. 14 (2017) 1711.10.1007/s13738-017-1112-2Suche in Google Scholar

26. W. Jost, Z. Phys. Chem. 26 (2011) 143.10.1524/zpch.1960.26.1_2.143Suche in Google Scholar

27. H. Zachmann, Z. Phys. Chem. 80 (2011) 106.10.1524/zpch.1972.80.1_2.106Suche in Google Scholar

28. G. Schwab, Z. Phys. Chem. 59 (2011) 341.10.1524/zpch.1968.59.5_6.341Suche in Google Scholar

29. J. Sommerer, M. Olzmann, Z. Phys. Chem. 229 (2014) 495.10.1515/zpch-2014-0618Suche in Google Scholar

30. K. G. Andrew, E. B. Michael, Thermochim. Acta 386 (2002) 91.10.1016/S0040-6031(01)00769-9Suche in Google Scholar

31. Y. Cheng, Y. Haung, K. Alexander, D. Dollimore, Thermochim. Acta 367–368 (2001) 23.10.1016/S0040-6031(00)00689-4Suche in Google Scholar

32. F. Rodante, G. Catalani, M. Tomassetti, J. Therm. Anal. Calorim. 66 (2001) 155.10.1023/A:1012495817109Suche in Google Scholar

33. A. A. Araújo, S. Storpirtis, L. P. Mercuri, F. M. Carvalho, M. Santos-Filho, J. R. Matose, Int. J. Pharm. 260 (2003) 303.10.1016/S0378-5173(03)00288-6Suche in Google Scholar PubMed

34. J. A. F. F. Rocco, J. E. S. Lima, A. G. Frutuoso, K. Iha, M. Ionashiro, J. R. Matos, M. E. V. Suárez-Iha, J. Therm. Anal. Calorim. 75 (2004) 551.10.1023/B:JTAN.0000027145.14854.f0Suche in Google Scholar

35. F. S. Felix, L. C. S. Cides, L. Angenes, J. R. Matos, J. Therm. Anal. Calorim. 95 (2009) 877.10.1007/s10973-007-8188-3Suche in Google Scholar

36. L. Burnham, D. Dollimore, K. Alexander, Thermochim. Acta 357–358 (2000) 15.10.1016/S0040-6031(00)00359-2Suche in Google Scholar

37. P. Paik, K. K. Kar, Polym. Degrad. Stabil. 93 (2008) 24.10.1016/j.polymdegradstab.2007.11.001Suche in Google Scholar

38. W. Tang, X. G. Li, D. Yan, J. Appl. Polym. Sci. 91 (2004) 445.10.1002/app.13103Suche in Google Scholar

39. F. Rodante, G. Catalani, S. Vecchio, J. Therm. Anal. Calorim. 68 (2002) 689.10.1023/A:1016024810586Suche in Google Scholar

40. L. C. S. Cides, A. A. S. Araujo, M. Santos-Filho, J. R. Matos, J. Therm. Anal. Calorim. 84 (2006) 441.10.1007/s10973-005-7131-8Suche in Google Scholar

41. T. Ozawa, Thermochim. Acta. 355 (2000) 35.10.1016/S0040-6031(00)00435-4Suche in Google Scholar

42. F. Ghaderi, M. Nemati, M. R. Siahi-Shadbad, H. Valizadeh, F. Monajjemzadeh, J. Therm. Anal. Calorim. 123 (2016) 2081.10.1007/s10973-015-4995-0Suche in Google Scholar

43. S. A. El-Zahaby, A. A. Kassem, A. H. El-Kamel, Saudi Pharm. J. 22 (2014) 570.10.1016/j.jsps.2014.02.009Suche in Google Scholar PubMed PubMed Central

44. N. Doodipala, C. R. Palm, S. Reddy, Y. M. Rao, Int. J. Pharm. Sci. Nanotechnol. 4 (2011) 1463.Suche in Google Scholar

45. P. N. Pereira, C. Fandaruff, M. K. Riekes, G. A. Monti, C. E. M. Campos, S. L. Cuffini, M. A. S. Silva, J. Therm. Anal. Calorim. 119 (2015) 989.10.1007/s10973-014-4233-1Suche in Google Scholar

46. E. M. Gorman, B. Samas, E. J. Munson, J. Pharm. Sci. 101 (2012) 3319.10.1002/jps.23200Suche in Google Scholar PubMed

47. S. A. El-Zahaby, A. A. Kassem, A. H. El-Kamel, Int. J. Pharm. 464 (2014) 10.10.1016/j.ijpharm.2014.01.024Suche in Google Scholar PubMed

48. H. Kitaoka, C. Wada, R. Moroi, H. Hakusui, Chem. Pharm. Bull. 43 (1995) 649.10.1248/cpb.43.649Suche in Google Scholar

49. F. Ghaderi, M. Nemati, M. R. Siahi-Shadbad, H. Valizadeh, F. Monajjemzadeh, Powder Technol. 286 (2015) 845.10.1016/j.powtec.2015.09.007Suche in Google Scholar

Received: 2018-07-31
Accepted: 2019-02-21
Published Online: 2019-03-20
Published in Print: 2020-01-28

©2020 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 26.2.2024 von https://www.degruyter.com/document/doi/10.1515/zpch-2018-1273/html?lang=de
Button zum nach oben scrollen